Incidental Mutation 'IGL01470:Or8b38'
ID 88231
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8b38
Ensembl Gene ENSMUSG00000096424
Gene Name olfactory receptor family 8 subfamily B member 38
Synonyms MOR162-12, GA_x6K02T2PVTD-31740639-31741568, Olfr885
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # IGL01470
Quality Score
Status
Chromosome 9
Chromosomal Location 37972618-37973547 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 37973300 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 228 (H228L)
Ref Sequence ENSEMBL: ENSMUSP00000080646 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081985]
AlphaFold Q7TRE0
Predicted Effect possibly damaging
Transcript: ENSMUST00000081985
AA Change: H228L

PolyPhen 2 Score 0.580 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000080646
Gene: ENSMUSG00000096424
AA Change: H228L

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 224 1.1e-5 PFAM
Pfam:7tm_1 41 288 7.5e-24 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T C 14: 32,382,414 (GRCm39) T1184A possibly damaging Het
A2ml1 A G 6: 128,557,375 (GRCm39) I106T probably damaging Het
Asic4 C T 1: 75,427,510 (GRCm39) A12V probably damaging Het
Cacna1d A T 14: 29,821,099 (GRCm39) V1139D probably damaging Het
Edc4 T C 8: 106,616,613 (GRCm39) probably benign Het
Eif4h A T 5: 134,654,393 (GRCm39) probably null Het
Exog C A 9: 119,291,592 (GRCm39) Q290K probably damaging Het
Fam83c A T 2: 155,676,728 (GRCm39) I14K possibly damaging Het
Fes A T 7: 80,033,021 (GRCm39) Y268N probably benign Het
Fhod1 A G 8: 106,056,281 (GRCm39) L1144P probably damaging Het
Frem3 C T 8: 81,340,944 (GRCm39) T1079I probably damaging Het
Gbp10 A G 5: 105,368,980 (GRCm39) probably benign Het
Herc1 T C 9: 66,404,918 (GRCm39) V4496A possibly damaging Het
Lamb1 A G 12: 31,350,261 (GRCm39) R729G possibly damaging Het
Lifr T A 15: 7,205,147 (GRCm39) C461* probably null Het
Lypd6 T C 2: 50,078,795 (GRCm39) V97A probably benign Het
Map3k5 A G 10: 19,993,933 (GRCm39) E973G possibly damaging Het
Mep1b A T 18: 21,230,524 (GRCm39) N692I probably benign Het
Mrpl15 A G 1: 4,846,754 (GRCm39) V274A probably damaging Het
Naaa A G 5: 92,411,507 (GRCm39) I264T probably damaging Het
Nlrp4c T C 7: 6,103,783 (GRCm39) C906R possibly damaging Het
Or1j15 T A 2: 36,458,754 (GRCm39) L48H probably damaging Het
Or4x11 T C 2: 89,868,162 (GRCm39) W300R possibly damaging Het
Or5b95 T C 19: 12,658,035 (GRCm39) S188P possibly damaging Het
Or8k3 T C 2: 86,058,628 (GRCm39) N229S probably benign Het
Phc2 C T 4: 128,616,903 (GRCm39) T392I probably benign Het
Ptprg G A 14: 12,213,702 (GRCm38) W248* probably null Het
Pzp T A 6: 128,498,087 (GRCm39) E243D probably benign Het
Rbm33 T A 5: 28,592,846 (GRCm39) L542Q probably damaging Het
Recql4 G A 15: 76,593,144 (GRCm39) T229I probably benign Het
Ssbp3 T C 4: 106,894,855 (GRCm39) probably benign Het
Tfap2d A T 1: 19,218,620 (GRCm39) Q373L probably damaging Het
Timmdc1 A G 16: 38,338,902 (GRCm39) probably benign Het
Tiparp G T 3: 65,460,030 (GRCm39) G442* probably null Het
Vmn2r4 A T 3: 64,313,816 (GRCm39) N388K probably damaging Het
Vps13c T C 9: 67,820,209 (GRCm39) probably benign Het
Zfp551 A G 7: 12,152,468 (GRCm39) probably null Het
Other mutations in Or8b38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02441:Or8b38 APN 9 37,973,233 (GRCm39) missense probably benign 0.02
IGL03263:Or8b38 APN 9 37,973,009 (GRCm39) missense probably damaging 0.98
R1748:Or8b38 UTSW 9 37,972,796 (GRCm39) missense probably damaging 1.00
R1870:Or8b38 UTSW 9 37,972,646 (GRCm39) missense probably benign 0.24
R1920:Or8b38 UTSW 9 37,972,981 (GRCm39) missense probably damaging 1.00
R1921:Or8b38 UTSW 9 37,972,981 (GRCm39) missense probably damaging 1.00
R1922:Or8b38 UTSW 9 37,972,981 (GRCm39) missense probably damaging 1.00
R4073:Or8b38 UTSW 9 37,973,165 (GRCm39) missense probably damaging 1.00
R4727:Or8b38 UTSW 9 37,973,389 (GRCm39) missense probably damaging 1.00
R4945:Or8b38 UTSW 9 37,973,068 (GRCm39) missense probably damaging 1.00
R4950:Or8b38 UTSW 9 37,973,297 (GRCm39) missense probably damaging 1.00
R5116:Or8b38 UTSW 9 37,972,634 (GRCm39) missense probably benign
R5233:Or8b38 UTSW 9 37,973,446 (GRCm39) missense probably damaging 0.96
R5923:Or8b38 UTSW 9 37,973,154 (GRCm39) missense probably benign 0.08
R6668:Or8b38 UTSW 9 37,973,066 (GRCm39) missense possibly damaging 0.83
R8035:Or8b38 UTSW 9 37,972,961 (GRCm39) missense probably damaging 0.99
R9392:Or8b38 UTSW 9 37,973,195 (GRCm39) missense probably benign 0.01
R9481:Or8b38 UTSW 9 37,972,707 (GRCm39) missense probably benign 0.01
RF020:Or8b38 UTSW 9 37,972,620 (GRCm39) start codon destroyed probably null 0.01
Posted On 2013-11-18