Incidental Mutation 'IGL01473:Odad3'
ID 88366
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Odad3
Ensembl Gene ENSMUSG00000039632
Gene Name outer dynein arm docking complex subunit 3
Synonyms Ccdc151, C330001K17Rik, b2b1885Clo
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # IGL01473
Quality Score
Status
Chromosome 9
Chromosomal Location 21901167-21913930 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) C to A at 21906675 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000110993 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044926] [ENSMUST00000115336]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000044926
SMART Domains Protein: ENSMUSP00000041117
Gene: ENSMUSG00000039632

DomainStartEndE-ValueType
coiled coil region 88 286 N/A INTRINSIC
low complexity region 334 345 N/A INTRINSIC
coiled coil region 378 420 N/A INTRINSIC
low complexity region 495 514 N/A INTRINSIC
low complexity region 550 565 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000115336
SMART Domains Protein: ENSMUSP00000110993
Gene: ENSMUSG00000039632

DomainStartEndE-ValueType
coiled coil region 88 286 N/A INTRINSIC
low complexity region 335 346 N/A INTRINSIC
coiled coil region 379 421 N/A INTRINSIC
low complexity region 496 515 N/A INTRINSIC
low complexity region 551 566 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214420
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing coiled-coil domains. The encoded protein functions in outer dynein arm assembly and is required for motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mico homozygous for an ENU-induced allele exhibit dextrocardia associated with situs inversus totalis and hypoplastic spleen, adrenal anomalies and immotile/dyskinetic tracheal airway cilia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp13a5 T C 16: 29,135,542 (GRCm39) Y350C probably damaging Het
Clca3a1 C T 3: 144,713,539 (GRCm39) M697I probably benign Het
Clcn1 C A 6: 42,268,637 (GRCm39) A181D probably damaging Het
Cylc1 G T X: 110,166,449 (GRCm39) K243N unknown Het
Dsp A G 13: 38,351,547 (GRCm39) Y122C probably damaging Het
Exoc5 A G 14: 49,251,751 (GRCm39) V665A possibly damaging Het
Fcho1 G A 8: 72,164,782 (GRCm39) P500S probably benign Het
Flg2 A G 3: 93,110,327 (GRCm39) E785G unknown Het
Fpr1 A G 17: 18,097,954 (GRCm39) S12P possibly damaging Het
Hydin G T 8: 111,081,585 (GRCm39) G327V probably damaging Het
Hydin A T 8: 111,038,792 (GRCm39) M177L probably benign Het
Itga10 G A 3: 96,554,957 (GRCm39) G97E probably damaging Het
Khdc1c T A 1: 21,439,130 (GRCm39) Y39N possibly damaging Het
Lrp1b T G 2: 40,501,498 (GRCm39) T202P probably damaging Het
Marchf10 T C 11: 105,280,431 (GRCm39) K618R probably damaging Het
Mdc1 C A 17: 36,158,912 (GRCm39) L431I probably benign Het
Mmp17 A G 5: 129,683,472 (GRCm39) D536G probably benign Het
Myh8 G A 11: 67,192,651 (GRCm39) probably null Het
Pop4 A G 7: 37,963,820 (GRCm39) V154A probably benign Het
Ppp1r13l C T 7: 19,109,193 (GRCm39) R608C probably damaging Het
Prss36 T C 7: 127,543,873 (GRCm39) H166R probably damaging Het
Rab11fip3 C T 17: 26,287,709 (GRCm39) R148Q possibly damaging Het
Rbm39 T A 2: 156,014,899 (GRCm39) R49* probably null Het
S100a11 T C 3: 93,433,413 (GRCm39) C86R probably damaging Het
Skint7 T C 4: 111,839,402 (GRCm39) I232T probably damaging Het
Smchd1 G A 17: 71,696,745 (GRCm39) T1210I probably benign Het
Speg C T 1: 75,404,929 (GRCm39) T2907I possibly damaging Het
Spz1 A T 13: 92,711,764 (GRCm39) C237* probably null Het
Sun3 G T 11: 8,979,394 (GRCm39) D42E probably benign Het
Tgds C T 14: 118,365,626 (GRCm39) probably benign Het
Tnxb G A 17: 34,904,675 (GRCm39) D1270N probably damaging Het
Vmn2r78 A C 7: 86,569,520 (GRCm39) T138P possibly damaging Het
Wdfy1 T C 1: 79,685,182 (GRCm39) I351V probably benign Het
Other mutations in Odad3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01922:Odad3 APN 9 21,904,826 (GRCm39) unclassified probably benign
IGL02223:Odad3 APN 9 21,904,908 (GRCm39) missense probably damaging 1.00
IGL03161:Odad3 APN 9 21,913,611 (GRCm39) missense probably benign 0.02
IGL03269:Odad3 APN 9 21,909,339 (GRCm39) critical splice donor site probably null
R0118:Odad3 UTSW 9 21,906,353 (GRCm39) missense probably benign 0.03
R0129:Odad3 UTSW 9 21,904,848 (GRCm39) missense probably damaging 0.98
R0279:Odad3 UTSW 9 21,901,543 (GRCm39) unclassified probably benign
R0390:Odad3 UTSW 9 21,903,004 (GRCm39) missense probably benign 0.00
R1349:Odad3 UTSW 9 21,904,916 (GRCm39) missense probably damaging 1.00
R1372:Odad3 UTSW 9 21,904,916 (GRCm39) missense probably damaging 1.00
R1891:Odad3 UTSW 9 21,906,677 (GRCm39) splice site probably null
R2044:Odad3 UTSW 9 21,903,154 (GRCm39) missense possibly damaging 0.95
R5116:Odad3 UTSW 9 21,901,424 (GRCm39) makesense probably null
R5147:Odad3 UTSW 9 21,906,158 (GRCm39) missense probably benign 0.21
R5929:Odad3 UTSW 9 21,913,718 (GRCm39) missense possibly damaging 0.50
R6182:Odad3 UTSW 9 21,901,698 (GRCm39) missense probably damaging 1.00
R7253:Odad3 UTSW 9 21,913,767 (GRCm39) missense probably damaging 1.00
R7498:Odad3 UTSW 9 21,913,553 (GRCm39) missense probably damaging 1.00
R7742:Odad3 UTSW 9 21,904,193 (GRCm39) missense possibly damaging 0.82
R8331:Odad3 UTSW 9 21,903,007 (GRCm39) missense probably damaging 1.00
R8976:Odad3 UTSW 9 21,903,334 (GRCm39) unclassified probably benign
R9319:Odad3 UTSW 9 21,906,203 (GRCm39) missense probably damaging 1.00
R9324:Odad3 UTSW 9 21,903,207 (GRCm39) missense probably damaging 1.00
R9422:Odad3 UTSW 9 21,913,628 (GRCm39) missense possibly damaging 0.55
R9614:Odad3 UTSW 9 21,904,310 (GRCm39) missense probably benign 0.02
Z1176:Odad3 UTSW 9 21,901,720 (GRCm39) missense possibly damaging 0.77
Posted On 2013-11-18