Incidental Mutation 'IGL01475:Mob1b'
ID 88440
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mob1b
Ensembl Gene ENSMUSG00000006262
Gene Name MOB kinase activator 1B
Synonyms 1110003E08Rik, Mobkl1a
Accession Numbers
Essential gene? Probably non essential (E-score: 0.168) question?
Stock # IGL01475
Quality Score
Status
Chromosome 5
Chromosomal Location 88868730-88906314 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 88897502 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 137 (F137I)
Ref Sequence ENSEMBL: ENSMUSP00000108855 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006424] [ENSMUST00000113229]
AlphaFold Q8BPB0
Predicted Effect probably damaging
Transcript: ENSMUST00000006424
AA Change: F132I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000006424
Gene: ENSMUSG00000006262
AA Change: F132I

DomainStartEndE-ValueType
Pfam:Mob1_phocein 29 205 1.2e-83 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000113229
AA Change: F137I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000108855
Gene: ENSMUSG00000006262
AA Change: F137I

DomainStartEndE-ValueType
Mob1_phocein 31 209 2.18e-113 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125171
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155298
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700129C05Rik A T 14: 59,380,252 (GRCm39) N15K possibly damaging Het
Adam32 A T 8: 25,362,664 (GRCm39) I587K probably damaging Het
Adamtsl4 T C 3: 95,584,843 (GRCm39) S942G probably benign Het
Adamtsl5 A G 10: 80,180,750 (GRCm39) F104S probably damaging Het
Adgrf5 A G 17: 43,761,245 (GRCm39) D980G probably benign Het
Apba1 A T 19: 23,894,950 (GRCm39) D462V possibly damaging Het
Arhgef11 T C 3: 87,634,433 (GRCm39) probably benign Het
Cd74 T C 18: 60,943,393 (GRCm39) probably benign Het
Cdc16 T C 8: 13,831,542 (GRCm39) S592P probably benign Het
Cenpj A G 14: 56,802,502 (GRCm39) M21T possibly damaging Het
Col28a1 A G 6: 8,103,521 (GRCm39) L425S probably damaging Het
Dbt C T 3: 116,313,908 (GRCm39) T25I possibly damaging Het
Dguok C A 6: 83,467,552 (GRCm39) M98I possibly damaging Het
Dmxl1 T C 18: 50,004,781 (GRCm39) L943P probably damaging Het
Eloa G A 4: 135,738,231 (GRCm39) S243L probably benign Het
Enkur C A 2: 21,201,530 (GRCm39) A52S probably damaging Het
Ezh1 T C 11: 101,083,787 (GRCm39) E744G probably damaging Het
Fbxw11 T C 11: 32,672,101 (GRCm39) S190P possibly damaging Het
Foxb1 G A 9: 69,666,550 (GRCm39) probably benign Het
Gabra5 C T 7: 57,058,432 (GRCm39) G439S probably damaging Het
Gtf2h2 A T 13: 100,617,541 (GRCm39) V207D probably damaging Het
Hoatz A G 9: 51,011,358 (GRCm39) I93T probably benign Het
Krt76 A G 15: 101,796,948 (GRCm39) V317A probably benign Het
Lair1 C A 7: 4,012,683 (GRCm39) probably benign Het
Lrit2 T A 14: 36,791,051 (GRCm39) H243Q probably damaging Het
Mast3 C T 8: 71,232,174 (GRCm39) A1268T probably damaging Het
Matn2 G A 15: 34,316,671 (GRCm39) M4I possibly damaging Het
Mreg T C 1: 72,203,325 (GRCm39) probably benign Het
Nom1 T C 5: 29,651,272 (GRCm39) V684A possibly damaging Het
Pate2 T A 9: 35,580,998 (GRCm39) L1Q probably null Het
Pla2r1 T C 2: 60,271,425 (GRCm39) probably benign Het
Plxna1 A G 6: 89,331,870 (GRCm39) F447L possibly damaging Het
Pno1 A T 11: 17,160,992 (GRCm39) I114N probably damaging Het
Ppp1r7 T G 1: 93,288,540 (GRCm39) probably benign Het
Pprc1 T A 19: 46,059,968 (GRCm39) Y1503N probably benign Het
Rab30 T C 7: 92,484,930 (GRCm39) V132A probably damaging Het
Slc15a4 T C 5: 127,679,024 (GRCm39) T439A probably benign Het
Slc29a3 A G 10: 60,559,596 (GRCm39) V186A possibly damaging Het
Stxbp5l G A 16: 37,165,454 (GRCm39) T88I possibly damaging Het
Tarbp1 A G 8: 127,160,701 (GRCm39) V1250A probably benign Het
Tcte2 A T 17: 13,937,824 (GRCm39) probably benign Het
Trp53bp1 A T 2: 121,100,800 (GRCm39) probably null Het
Trpc4 A T 3: 54,173,828 (GRCm39) L407F possibly damaging Het
Vmn1r6 T C 6: 56,979,896 (GRCm39) F164S probably damaging Het
Zfp579 C A 7: 4,997,743 (GRCm39) R56L probably benign Het
Other mutations in Mob1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Mob1b APN 5 88,904,014 (GRCm39) missense probably benign 0.00
IGL02478:Mob1b APN 5 88,903,947 (GRCm39) splice site probably benign
R0012:Mob1b UTSW 5 88,903,943 (GRCm39) splice site probably benign
R0012:Mob1b UTSW 5 88,903,943 (GRCm39) splice site probably benign
R0938:Mob1b UTSW 5 88,897,452 (GRCm39) missense probably damaging 1.00
R1081:Mob1b UTSW 5 88,901,021 (GRCm39) missense probably benign 0.00
R3500:Mob1b UTSW 5 88,897,479 (GRCm39) missense probably benign 0.00
R3890:Mob1b UTSW 5 88,901,061 (GRCm39) missense probably damaging 0.97
R3891:Mob1b UTSW 5 88,901,061 (GRCm39) missense probably damaging 0.97
R3892:Mob1b UTSW 5 88,901,061 (GRCm39) missense probably damaging 0.97
R7243:Mob1b UTSW 5 88,891,304 (GRCm39) missense probably damaging 0.96
R7302:Mob1b UTSW 5 88,901,036 (GRCm39) missense probably benign
R7782:Mob1b UTSW 5 88,897,542 (GRCm39) splice site probably null
R8101:Mob1b UTSW 5 88,901,093 (GRCm39) missense probably benign 0.10
R9160:Mob1b UTSW 5 88,904,017 (GRCm39) missense probably benign 0.08
Posted On 2013-11-18