Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01477:Armh3'

88485

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Armh3

Ensembl Gene

ENSMUSG00000039901

Gene Name

armadillo-like helical domain containing 3

Synonyms

9130011E15Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01477

Quality Score

Status

Chromosome

Chromosomal Location

45805803-45986927 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 45967043 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 33 (F33S)

Ref Sequence

ENSEMBL: ENSMUSP00000048454 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045396]

AlphaFold

Q6PD19

Predicted Effect

probably damaging
Transcript: ENSMUST00000045396
AA Change: F33S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000048454
Gene: ENSMUSG00000039901
AA Change: F33S

Domain	Start	End	E-Value	Type
low complexity region	155	167	N/A	INTRINSIC
low complexity region	327	348	N/A	INTRINSIC
DUF1741	435	671	5.65e-139	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aven	T	C	2: 112,460,277 (GRCm39)	S132P	probably benign	Het
Cadps2	G	A	6: 23,263,672 (GRCm39)	T1233M	probably damaging	Het
Cdh16	T	C	8: 105,345,140 (GRCm39)	E383G	probably damaging	Het
Cxxc1	A	G	18: 74,352,985 (GRCm39)	K432E	possibly damaging	Het
Elapor2	A	T	5: 9,487,756 (GRCm39)	K547N	probably damaging	Het
Eprs1	G	T	1: 185,143,572 (GRCm39)		probably benign	Het
Etv4	T	C	11: 101,667,954 (GRCm39)	D74G	possibly damaging	Het
Glb1l	A	T	1: 75,185,350 (GRCm39)	I120N	probably damaging	Het
Grpel1	G	A	5: 36,627,986 (GRCm39)	R89Q	probably damaging	Het
Ifi44	C	T	3: 151,451,635 (GRCm39)		probably benign	Het
Ikzf3	T	C	11: 98,379,683 (GRCm39)	H195R	probably damaging	Het
Mug2	A	G	6: 122,058,643 (GRCm39)		probably benign	Het
Or1j15	T	A	2: 36,458,754 (GRCm39)	L48H	probably damaging	Het
Or8c17	T	A	9: 38,180,615 (GRCm39)	S269T	possibly damaging	Het
Pcnx1	A	T	12: 82,020,015 (GRCm39)	K1346I	probably damaging	Het
Pcnx2	C	T	8: 126,512,044 (GRCm39)	V1421I	probably damaging	Het
Pnpla8	A	G	12: 44,330,441 (GRCm39)	D331G	probably damaging	Het
Ppp1r3a	A	T	6: 14,718,345 (GRCm39)	N856K	probably damaging	Het
Ptk7	T	C	17: 46,887,806 (GRCm39)	D542G	possibly damaging	Het
Slc4a2	A	G	5: 24,635,154 (GRCm39)		probably benign	Het
Smarce1	C	T	11: 99,101,013 (GRCm39)	G373E	possibly damaging	Het
Speg	A	G	1: 75,368,541 (GRCm39)	N697S	probably damaging	Het
Supt5	T	C	7: 28,016,689 (GRCm39)	H731R	possibly damaging	Het
Tmod2	T	C	9: 75,502,283 (GRCm39)	H68R	probably benign	Het
Vmn2r68	A	C	7: 84,882,691 (GRCm39)	C354G	probably damaging	Het
Zfp277	A	T	12: 40,370,675 (GRCm39)	Y425N	probably benign	Het

Other mutations in Armh3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00392:Armh3	APN	19	45,928,927 (GRCm39)	missense	probably benign	0.19
IGL00788:Armh3	APN	19	45,920,789 (GRCm39)	critical splice donor site	probably null
IGL01356:Armh3	APN	19	45,954,742 (GRCm39)	missense	possibly damaging	0.94
IGL01660:Armh3	APN	19	45,928,915 (GRCm39)	missense	probably damaging	1.00
IGL02193:Armh3	APN	19	45,961,323 (GRCm39)	missense	probably benign	0.02
IGL02863:Armh3	APN	19	45,946,850 (GRCm39)	missense	probably damaging	1.00
IGL03108:Armh3	APN	19	45,808,792 (GRCm39)	missense	probably damaging	0.99
R0035:Armh3	UTSW	19	45,879,679 (GRCm39)	missense	probably damaging	1.00
R0791:Armh3	UTSW	19	45,922,307 (GRCm39)	splice site	probably null
R0792:Armh3	UTSW	19	45,922,307 (GRCm39)	splice site	probably null
R1487:Armh3	UTSW	19	45,928,882 (GRCm39)	critical splice donor site	probably null
R1843:Armh3	UTSW	19	45,963,691 (GRCm39)	missense	probably benign	0.17
R2061:Armh3	UTSW	19	45,967,106 (GRCm39)	missense	probably damaging	1.00
R2070:Armh3	UTSW	19	45,879,724 (GRCm39)	missense	probably damaging	1.00
R2072:Armh3	UTSW	19	45,953,820 (GRCm39)	missense	probably damaging	0.99
R2073:Armh3	UTSW	19	45,953,820 (GRCm39)	missense	probably damaging	0.99
R2074:Armh3	UTSW	19	45,953,820 (GRCm39)	missense	probably damaging	0.99
R2091:Armh3	UTSW	19	45,941,119 (GRCm39)	missense	probably damaging	1.00
R2263:Armh3	UTSW	19	45,920,788 (GRCm39)	critical splice donor site	probably null
R2863:Armh3	UTSW	19	45,874,396 (GRCm39)	missense	probably damaging	1.00
R3236:Armh3	UTSW	19	45,963,722 (GRCm39)	splice site	probably benign
R3796:Armh3	UTSW	19	45,910,049 (GRCm39)	splice site	probably benign
R4044:Armh3	UTSW	19	45,808,763 (GRCm39)	missense	probably damaging	1.00
R4716:Armh3	UTSW	19	45,948,781 (GRCm39)	missense	probably damaging	1.00
R4974:Armh3	UTSW	19	45,808,726 (GRCm39)	missense	probably damaging	1.00
R4983:Armh3	UTSW	19	45,939,146 (GRCm39)	missense	probably benign
R5063:Armh3	UTSW	19	45,874,394 (GRCm39)	missense	possibly damaging	0.95
R5313:Armh3	UTSW	19	45,807,414 (GRCm39)	missense	probably damaging	1.00
R5782:Armh3	UTSW	19	45,874,466 (GRCm39)	missense	probably benign	0.08
R5985:Armh3	UTSW	19	45,808,763 (GRCm39)	missense	probably damaging	1.00
R6220:Armh3	UTSW	19	45,834,554 (GRCm39)	missense	possibly damaging	0.79
R6379:Armh3	UTSW	19	45,910,136 (GRCm39)	missense	possibly damaging	0.46
R6674:Armh3	UTSW	19	45,963,437 (GRCm39)	missense	probably benign	0.06
R6842:Armh3	UTSW	19	45,807,416 (GRCm39)	missense	probably benign	0.05
R6890:Armh3	UTSW	19	45,948,796 (GRCm39)	missense	probably damaging	1.00
R7034:Armh3	UTSW	19	45,953,688 (GRCm39)	missense	probably damaging	0.98
R7036:Armh3	UTSW	19	45,953,688 (GRCm39)	missense	probably damaging	0.98
R7305:Armh3	UTSW	19	45,880,560 (GRCm39)	missense	probably benign	0.35
R7411:Armh3	UTSW	19	45,953,874 (GRCm39)	missense	probably benign	0.00
R7762:Armh3	UTSW	19	45,928,882 (GRCm39)	critical splice donor site	probably null
R8021:Armh3	UTSW	19	45,945,180 (GRCm39)	critical splice acceptor site	probably null
R8366:Armh3	UTSW	19	45,920,793 (GRCm39)	missense	probably damaging	1.00
R9336:Armh3	UTSW	19	45,945,120 (GRCm39)	missense	probably damaging	1.00
X0060:Armh3	UTSW	19	45,920,832 (GRCm39)	missense	possibly damaging	0.95
Z1088:Armh3	UTSW	19	45,807,344 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-11-18