Incidental Mutation 'IGL01477:Olfr895'
ID 88490
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr895
Ensembl Gene ENSMUSG00000096427
Gene Name olfactory receptor 895
Synonyms MOR170-1, GA_x6K02T2PVTD-31962461-31963411
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.096) question?
Stock # IGL01477
Quality Score
Chromosome 9
Chromosomal Location 38267851-38269735 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38269319 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 269 (S269T)
Ref Sequence ENSEMBL: ENSMUSP00000091387 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093864] [ENSMUST00000212156]
AlphaFold L7N210
Predicted Effect possibly damaging
Transcript: ENSMUST00000093864
AA Change: S269T

PolyPhen 2 Score 0.736 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000091387
Gene: ENSMUSG00000096427
AA Change: S269T

Pfam:7tm_4 37 313 4.6e-47 PFAM
Pfam:7tm_1 47 246 3.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212156
AA Change: S261T

PolyPhen 2 Score 0.446 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130011E15Rik A G 19: 45,978,604 F33S probably damaging Het
9330182L06Rik A T 5: 9,437,756 K547N probably damaging Het
Aven T C 2: 112,629,932 S132P probably benign Het
Cadps2 G A 6: 23,263,673 T1233M probably damaging Het
Cdh16 T C 8: 104,618,508 E383G probably damaging Het
Cxxc1 A G 18: 74,219,914 K432E possibly damaging Het
Eprs G T 1: 185,411,375 probably benign Het
Etv4 T C 11: 101,777,128 D74G possibly damaging Het
Glb1l A T 1: 75,208,706 I120N probably damaging Het
Grpel1 G A 5: 36,470,642 R89Q probably damaging Het
Ifi44 C T 3: 151,745,998 probably benign Het
Ikzf3 T C 11: 98,488,857 H195R probably damaging Het
Mug2 A G 6: 122,081,684 probably benign Het
Olfr344 T A 2: 36,568,742 L48H probably damaging Het
Pcnx A T 12: 81,973,241 K1346I probably damaging Het
Pcnx2 C T 8: 125,785,305 V1421I probably damaging Het
Pnpla8 A G 12: 44,283,658 D331G probably damaging Het
Ppp1r3a A T 6: 14,718,346 N856K probably damaging Het
Ptk7 T C 17: 46,576,880 D542G possibly damaging Het
Slc4a2 A G 5: 24,430,156 probably benign Het
Smarce1 C T 11: 99,210,187 G373E possibly damaging Het
Speg A G 1: 75,391,897 N697S probably damaging Het
Supt5 T C 7: 28,317,264 H731R possibly damaging Het
Tmod2 T C 9: 75,595,001 H68R probably benign Het
Vmn2r68 A C 7: 85,233,483 C354G probably damaging Het
Zfp277 A T 12: 40,320,676 Y425N probably benign Het
Other mutations in Olfr895
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00952:Olfr895 APN 9 38268505 splice site probably benign
IGL02150:Olfr895 APN 9 38269268 missense possibly damaging 0.56
R0616:Olfr895 UTSW 9 38269334 missense probably benign 0.08
R0738:Olfr895 UTSW 9 38269125 missense possibly damaging 0.93
R3155:Olfr895 UTSW 9 38268540 start codon destroyed probably null 0.98
R3824:Olfr895 UTSW 9 38268518 missense probably benign
R3825:Olfr895 UTSW 9 38268518 missense probably benign
R4023:Olfr895 UTSW 9 38269461 missense possibly damaging 0.83
R4687:Olfr895 UTSW 9 38269414 missense probably damaging 1.00
R4692:Olfr895 UTSW 9 38268530 nonsense probably null
R6171:Olfr895 UTSW 9 38268602 nonsense probably null
R6736:Olfr895 UTSW 9 38268570 missense probably damaging 1.00
R6950:Olfr895 UTSW 9 38268546 missense probably damaging 1.00
R7256:Olfr895 UTSW 9 38268708 missense probably damaging 0.98
R7774:Olfr895 UTSW 9 38269359 missense probably damaging 0.99
R7937:Olfr895 UTSW 9 38269048 missense probably benign 0.16
R8354:Olfr895 UTSW 9 38269217 missense probably benign 0.02
R8772:Olfr895 UTSW 9 38268935 missense probably benign 0.00
R8863:Olfr895 UTSW 9 38269359 missense probably damaging 0.99
R9371:Olfr895 UTSW 9 38268630 missense possibly damaging 0.94
Z1088:Olfr895 UTSW 9 38268612 missense probably damaging 1.00
Posted On 2013-11-18