Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01478:Igsf23'

88531

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Igsf23

Ensembl Gene

ENSMUSG00000040498

Gene Name

immunoglobulin superfamily, member 23

Synonyms

2210010C17Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.119) question?

Stock #

IGL01478

Quality Score

Status

Chromosome

Chromosomal Location

19671230-19684681 bp(-) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

G to A at 19672161 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000147077 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043440] [ENSMUST00000208974]

AlphaFold

B2RTN2

Predicted Effect

probably benign
Transcript: ENSMUST00000043440

SMART Domains

Protein: ENSMUSP00000047914
Gene: ENSMUSG00000040498

Domain	Start	End	E-Value	Type
signal peptide	1	34	N/A	INTRINSIC
IG	107	181	2.71e0	SMART
low complexity region	182	195	N/A	INTRINSIC
transmembrane domain	213	235	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207513

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208210

Predicted Effect

probably benign
Transcript: ENSMUST00000208974

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that has one immunoglobulin (Ig) domain and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Nov 2011]

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	A	G	6: 91,911,590 (GRCm39)	T613A	probably benign	Het
Cdh16	G	T	8: 105,341,120 (GRCm39)		probably benign	Het
Epn2	A	G	11: 61,413,912 (GRCm39)	S419P	probably benign	Het
Eral1	A	T	11: 77,966,558 (GRCm39)	V234D	probably damaging	Het
Fhad1	T	C	4: 141,678,949 (GRCm39)	K576E	possibly damaging	Het
Frmd4b	T	A	6: 97,305,254 (GRCm39)	D170V	probably damaging	Het
Gm4353	A	G	7: 115,682,975 (GRCm39)	V202A	possibly damaging	Het
Ighmbp2	A	G	19: 3,324,531 (GRCm39)	I245T	probably benign	Het
Krt1	A	G	15: 101,754,721 (GRCm39)		probably benign	Het
Mapk8	A	G	14: 33,105,857 (GRCm39)	V371A	probably benign	Het
Mtrf1	T	G	14: 79,640,360 (GRCm39)		probably benign	Het
Myzap	A	G	9: 71,422,349 (GRCm39)		probably null	Het
Nsrp1	C	T	11: 76,941,478 (GRCm39)	V73I	probably benign	Het
Or1j15	T	A	2: 36,458,754 (GRCm39)	L48H	probably damaging	Het
Or52e18	A	G	7: 104,609,555 (GRCm39)	I128T	probably damaging	Het
Or8k39	A	T	2: 86,563,673 (GRCm39)	Y94*	probably null	Het
Pex6	C	T	17: 47,036,230 (GRCm39)	R976C	probably benign	Het
Ranbp9	G	A	13: 43,567,560 (GRCm39)	T546I	probably benign	Het
Rfx5	T	C	3: 94,865,751 (GRCm39)	V350A	possibly damaging	Het
Rnf19b	A	G	4: 128,952,623 (GRCm39)	E187G	probably damaging	Het
Sbf1	A	G	15: 89,183,946 (GRCm39)	V1217A	probably damaging	Het
Sfmbt1	T	A	14: 30,533,478 (GRCm39)	D618E	probably damaging	Het
Sipa1l1	A	G	12: 82,493,672 (GRCm39)	E1697G	probably benign	Het
Syk	A	G	13: 52,778,784 (GRCm39)	Y290C	probably benign	Het
Trim69	T	C	2: 122,008,924 (GRCm39)	L328P	probably damaging	Het
Unc5c	T	A	3: 141,534,212 (GRCm39)	I911N	probably damaging	Het
Wdr5	T	C	2: 27,423,844 (GRCm39)	V294A	probably damaging	Het

Other mutations in Igsf23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0334:Igsf23	UTSW	7	19,675,678 (GRCm39)	missense	probably benign	0.27
R0831:Igsf23	UTSW	7	19,675,662 (GRCm39)	splice site	probably benign
R2351:Igsf23	UTSW	7	19,678,723 (GRCm39)	nonsense	probably null
R4835:Igsf23	UTSW	7	19,675,755 (GRCm39)	missense	possibly damaging	0.80
R4850:Igsf23	UTSW	7	19,687,859 (GRCm39)	unclassified	probably benign
R6739:Igsf23	UTSW	7	19,678,673 (GRCm39)	missense	probably damaging	0.97
R6924:Igsf23	UTSW	7	19,675,684 (GRCm39)	missense	possibly damaging	0.83
R8244:Igsf23	UTSW	7	19,675,798 (GRCm39)	missense	possibly damaging	0.66
R8285:Igsf23	UTSW	7	19,675,881 (GRCm39)	missense	possibly damaging	0.90
R9747:Igsf23	UTSW	7	19,675,839 (GRCm39)	missense	probably benign	0.09

Posted On

2013-11-18