Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01479:Zfp64'

88558

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp64

Ensembl Gene

ENSMUSG00000027551

Gene Name

zinc finger protein 64

Synonyms

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.800) question?

Stock #

IGL01479

Quality Score

Status

Chromosome

Chromosomal Location

168893331-168955587 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 168951679 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 49 (H49R)

Ref Sequence

ENSEMBL: ENSMUSP00000085285 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087971] [ENSMUST00000109161] [ENSMUST00000109162]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000087971
AA Change: H49R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000085285
Gene: ENSMUSG00000027551
AA Change: H49R

Domain	Start	End	E-Value	Type
ZnF_C2H2	31	51	5.54e1	SMART
low complexity region	71	93	N/A	INTRINSIC
ZnF_C2H2	142	167	1.68e1	SMART
ZnF_C2H2	173	195	2.24e-3	SMART
ZnF_C2H2	201	223	1.58e-3	SMART
ZnF_C2H2	229	251	2.24e-3	SMART
ZnF_C2H2	257	279	3.89e-3	SMART
ZnF_C2H2	285	308	6.32e-3	SMART
ZnF_C2H2	313	335	2.05e-2	SMART
ZnF_C2H2	341	363	1.95e-3	SMART
ZnF_C2H2	369	392	1.36e-2	SMART
ZnF_C2H2	423	445	1.47e-3	SMART
low complexity region	503	522	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000109161
AA Change: H49R

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000104789
Gene: ENSMUSG00000027551
AA Change: H49R

Domain	Start	End	E-Value	Type
ZnF_C2H2	31	51	5.54e1	SMART
low complexity region	71	93	N/A	INTRINSIC
ZnF_C2H2	142	167	1.68e1	SMART
ZnF_C2H2	173	195	2.24e-3	SMART
ZnF_C2H2	201	223	1.58e-3	SMART
ZnF_C2H2	229	251	2.24e-3	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000109162
AA Change: H49R

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000104790
Gene: ENSMUSG00000027551
AA Change: H49R

Domain	Start	End	E-Value	Type
ZnF_C2H2	31	51	5.54e1	SMART
low complexity region	71	93	N/A	INTRINSIC
ZnF_C2H2	142	167	1.68e1	SMART
ZnF_C2H2	173	195	2.24e-3	SMART
ZnF_C2H2	201	223	1.58e-3	SMART
ZnF_C2H2	229	251	2.24e-3	SMART
ZnF_C2H2	297	322	5.2e0	SMART
ZnF_C2H2	328	350	4.17e-3	SMART
ZnF_C2H2	356	378	6.78e-3	SMART
ZnF_C2H2	384	406	2.24e-3	SMART
ZnF_C2H2	412	434	1.79e-2	SMART
ZnF_C2H2	440	463	9.58e-3	SMART
ZnF_C2H2	465	487	3.78e-1	SMART
ZnF_C2H2	493	515	3.89e-3	SMART
ZnF_C2H2	521	544	1.92e-2	SMART
ZnF_C2H2	578	600	5.34e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136242

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1c12	T	C	13: 4,272,935	K225R	probably benign	Het
Amn	C	A	12: 111,271,793	A47E	probably damaging	Het
Arhgef1	T	C	7: 24,912,603	I137T	probably benign	Het
Cep57l1	T	C	10: 41,728,639	K165E	possibly damaging	Het
Chfr	A	G	5: 110,144,993		probably benign	Het
Dnah9	A	G	11: 65,955,717	V2923A	probably benign	Het
Dnaja2	T	C	8: 85,553,951	Y35C	probably damaging	Het
Dnajc2	T	C	5: 21,757,893	T481A	probably damaging	Het
Foxred2	A	G	15: 77,952,289		probably null	Het
Gin1	C	T	1: 97,792,372	T364I	possibly damaging	Het
Glt8d2	C	T	10: 82,660,736	V163I	probably damaging	Het
Gm10118	T	C	10: 63,926,820		probably benign	Het
Hps5	C	T	7: 46,762,942		probably null	Het
Kdm4c	A	G	4: 74,343,501	K638E	probably benign	Het
L3mbtl2	A	G	15: 81,676,392	T285A	probably benign	Het
Mab21l1	A	G	3: 55,783,832	Y280C	probably damaging	Het
Mcoln2	T	A	3: 146,175,652		probably benign	Het
Myo9b	G	T	8: 71,359,342	R1926L	probably damaging	Het
Rrp12	A	G	19: 41,865,202	V1251A	probably benign	Het
Rtn4rl1	A	G	11: 75,265,342	D200G	probably damaging	Het
Sbsn	G	A	7: 30,752,357	A266T	possibly damaging	Het
Sgca	A	T	11: 94,963,378	C335*	probably null	Het
Spag1	T	C	15: 36,233,199		probably benign	Het
Sult6b1	A	T	17: 78,905,576	V82D	probably benign	Het
Tigit	T	C	16: 43,659,522	T137A	probably benign	Het
Tmem125	G	A	4: 118,541,623	Q204*	probably null	Het
Tmem59l	C	T	8: 70,486,098	R111Q	probably benign	Het
Vmn2r95	G	A	17: 18,443,862	G448R	probably damaging	Het

Other mutations in Zfp64

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Zfp64	APN	2	168926681	missense	probably benign	0.06
IGL02320:Zfp64	APN	2	168926198	missense	probably damaging	0.98
IGL03411:Zfp64	APN	2	168951542	splice site	probably null
PIT4362001:Zfp64	UTSW	2	168925815	missense	probably benign	0.23
R0033:Zfp64	UTSW	2	168925715	missense	possibly damaging	0.94
R0033:Zfp64	UTSW	2	168925715	missense	possibly damaging	0.94
R0230:Zfp64	UTSW	2	168912230	splice site	probably benign
R0325:Zfp64	UTSW	2	168926040	missense	probably benign	0.00
R0689:Zfp64	UTSW	2	168935201	splice site	probably benign
R1741:Zfp64	UTSW	2	168926318	missense	probably benign	0.05
R2054:Zfp64	UTSW	2	168925808	missense	probably damaging	1.00
R2133:Zfp64	UTSW	2	168940743	missense	probably damaging	1.00
R2254:Zfp64	UTSW	2	168926742	missense	probably damaging	0.96
R4093:Zfp64	UTSW	2	168925935	missense	probably benign	0.00
R4094:Zfp64	UTSW	2	168925935	missense	probably benign	0.00
R4257:Zfp64	UTSW	2	168926378	missense	probably damaging	1.00
R4630:Zfp64	UTSW	2	168926543	missense	possibly damaging	0.94
R4642:Zfp64	UTSW	2	168934931	missense	probably benign	0.22
R4817:Zfp64	UTSW	2	168926112	missense	probably benign
R4880:Zfp64	UTSW	2	168894377	missense	probably damaging	1.00
R5051:Zfp64	UTSW	2	168926384	missense	probably damaging	0.98
R5155:Zfp64	UTSW	2	168906965	missense	probably benign	0.17
R5562:Zfp64	UTSW	2	168925722	missense	probably benign	0.00
R5619:Zfp64	UTSW	2	168899814	missense	probably damaging	0.99
R5619:Zfp64	UTSW	2	168899815	missense	probably damaging	0.97
R5620:Zfp64	UTSW	2	168899968	missense	possibly damaging	0.70
R5919:Zfp64	UTSW	2	168926499	missense	probably benign	0.05
R6156:Zfp64	UTSW	2	168926168	missense	probably benign	0.34
R6364:Zfp64	UTSW	2	168912266	missense	probably damaging	1.00
R6488:Zfp64	UTSW	2	168935209	critical splice donor site	probably null
R6512:Zfp64	UTSW	2	168894077	missense	probably benign	0.00
R6588:Zfp64	UTSW	2	168926907	missense	probably damaging	1.00
R7103:Zfp64	UTSW	2	168926437	missense	probably benign	0.00
R7313:Zfp64	UTSW	2	168899890	missense	probably damaging	1.00
R7470:Zfp64	UTSW	2	168925811	missense	probably damaging	1.00
R7529:Zfp64	UTSW	2	168894072	missense	probably benign
R7560:Zfp64	UTSW	2	168925665	missense	probably damaging	1.00
R7963:Zfp64	UTSW	2	168951618	missense	probably benign	0.32
R8037:Zfp64	UTSW	2	168900012	missense	probably damaging	1.00
R8038:Zfp64	UTSW	2	168900012	missense	probably damaging	1.00
R8825:Zfp64	UTSW	2	168951632	missense	probably benign
R8840:Zfp64	UTSW	2	168926715	missense	probably benign
R8891:Zfp64	UTSW	2	168955163	start codon destroyed	probably null	0.37
R9062:Zfp64	UTSW	2	168925827	missense	probably benign

Posted On

2013-11-18