Incidental Mutation 'IGL01479:Foxred2'
| ID |
88561 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Foxred2
|
| Ensembl Gene |
ENSMUSG00000016552 |
| Gene Name |
FAD-dependent oxidoreductase domain containing 2 |
| Synonyms |
D15Bwg0759e, A430097D04Rik, LOC239554 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01479
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
77824722-77840922 bp(-) (GRCm39) |
| Type of Mutation |
splice site (6 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 77836489 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113403
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000016696]
[ENSMUST00000117725]
|
| AlphaFold |
Q3USW5 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000016696
|
| SMART Domains |
Protein: ENSMUSP00000016696
Gene: ENSMUSG00000016552
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:Pyr_redox_2
|
22 |
243 |
2.9e-11 |
PFAM |
|
Pfam:Pyr_redox_3
|
25 |
240 |
9.3e-35 |
PFAM |
|
Pfam:NAD_binding_8
|
26 |
84 |
3.3e-6 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000117725
|
| SMART Domains |
Protein: ENSMUSP00000113403
Gene: ENSMUSG00000016552
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:Pyr_redox_2
|
23 |
478 |
3.4e-9 |
PFAM |
|
Pfam:Pyr_redox_3
|
25 |
240 |
6.2e-37 |
PFAM |
|
Pfam:NAD_binding_8
|
26 |
90 |
4.8e-7 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129045
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akr1c12 |
T |
C |
13: 4,322,934 (GRCm39) |
K225R |
probably benign |
Het |
| Amn |
C |
A |
12: 111,238,227 (GRCm39) |
A47E |
probably damaging |
Het |
| Arhgef1 |
T |
C |
7: 24,612,028 (GRCm39) |
I137T |
probably benign |
Het |
| Cep57l1 |
T |
C |
10: 41,604,635 (GRCm39) |
K165E |
possibly damaging |
Het |
| Chfr |
A |
G |
5: 110,292,859 (GRCm39) |
|
probably benign |
Het |
| Dnah9 |
A |
G |
11: 65,846,543 (GRCm39) |
V2923A |
probably benign |
Het |
| Dnaja2 |
T |
C |
8: 86,280,580 (GRCm39) |
Y35C |
probably damaging |
Het |
| Dnajc2 |
T |
C |
5: 21,962,891 (GRCm39) |
T481A |
probably damaging |
Het |
| Gin1 |
C |
T |
1: 97,720,097 (GRCm39) |
T364I |
possibly damaging |
Het |
| Glt8d2 |
C |
T |
10: 82,496,570 (GRCm39) |
V163I |
probably damaging |
Het |
| Gm10118 |
T |
C |
10: 63,762,599 (GRCm39) |
|
probably benign |
Het |
| Hps5 |
C |
T |
7: 46,412,366 (GRCm39) |
|
probably null |
Het |
| Kdm4c |
A |
G |
4: 74,261,738 (GRCm39) |
K638E |
probably benign |
Het |
| L3mbtl2 |
A |
G |
15: 81,560,593 (GRCm39) |
T285A |
probably benign |
Het |
| Mab21l1 |
A |
G |
3: 55,691,253 (GRCm39) |
Y280C |
probably damaging |
Het |
| Mcoln2 |
T |
A |
3: 145,881,407 (GRCm39) |
|
probably benign |
Het |
| Myo9b |
G |
T |
8: 71,811,986 (GRCm39) |
R1926L |
probably damaging |
Het |
| Rrp12 |
A |
G |
19: 41,853,641 (GRCm39) |
V1251A |
probably benign |
Het |
| Rtn4rl1 |
A |
G |
11: 75,156,168 (GRCm39) |
D200G |
probably damaging |
Het |
| Sbsn |
G |
A |
7: 30,451,782 (GRCm39) |
A266T |
possibly damaging |
Het |
| Sgca |
A |
T |
11: 94,854,204 (GRCm39) |
C335* |
probably null |
Het |
| Spag1 |
T |
C |
15: 36,233,345 (GRCm39) |
|
probably benign |
Het |
| Sult6b1 |
A |
T |
17: 79,213,005 (GRCm39) |
V82D |
probably benign |
Het |
| Tigit |
T |
C |
16: 43,479,885 (GRCm39) |
T137A |
probably benign |
Het |
| Tmem125 |
G |
A |
4: 118,398,820 (GRCm39) |
Q204* |
probably null |
Het |
| Tmem59l |
C |
T |
8: 70,938,748 (GRCm39) |
R111Q |
probably benign |
Het |
| Vmn2r95 |
G |
A |
17: 18,664,124 (GRCm39) |
G448R |
probably damaging |
Het |
| Zfp64 |
T |
C |
2: 168,793,599 (GRCm39) |
H49R |
probably damaging |
Het |
|
| Other mutations in Foxred2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01394:Foxred2
|
APN |
15 |
77,839,820 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01748:Foxred2
|
APN |
15 |
77,836,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Foxred2
|
APN |
15 |
77,839,850 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02328:Foxred2
|
APN |
15 |
77,840,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02630:Foxred2
|
APN |
15 |
77,831,362 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02672:Foxred2
|
APN |
15 |
77,829,777 (GRCm39) |
critical splice donor site |
probably null |
|
|
soma
|
UTSW |
15 |
77,837,558 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0271:Foxred2
|
UTSW |
15 |
77,827,590 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1386:Foxred2
|
UTSW |
15 |
77,832,721 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1581:Foxred2
|
UTSW |
15 |
77,839,961 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4399:Foxred2
|
UTSW |
15 |
77,839,880 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4399:Foxred2
|
UTSW |
15 |
77,837,558 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R4528:Foxred2
|
UTSW |
15 |
77,827,449 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4937:Foxred2
|
UTSW |
15 |
77,840,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5165:Foxred2
|
UTSW |
15 |
77,840,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5318:Foxred2
|
UTSW |
15 |
77,836,598 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5893:Foxred2
|
UTSW |
15 |
77,831,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6336:Foxred2
|
UTSW |
15 |
77,839,964 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6370:Foxred2
|
UTSW |
15 |
77,827,506 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6426:Foxred2
|
UTSW |
15 |
77,837,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6826:Foxred2
|
UTSW |
15 |
77,831,285 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6891:Foxred2
|
UTSW |
15 |
77,839,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6934:Foxred2
|
UTSW |
15 |
77,836,530 (GRCm39) |
nonsense |
probably null |
|
|
R7193:Foxred2
|
UTSW |
15 |
77,836,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7821:Foxred2
|
UTSW |
15 |
77,827,550 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8401:Foxred2
|
UTSW |
15 |
77,836,191 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8540:Foxred2
|
UTSW |
15 |
77,836,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8844:Foxred2
|
UTSW |
15 |
77,832,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8916:Foxred2
|
UTSW |
15 |
77,837,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8963:Foxred2
|
UTSW |
15 |
77,829,805 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9104:Foxred2
|
UTSW |
15 |
77,836,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Foxred2
|
UTSW |
15 |
77,839,787 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9205:Foxred2
|
UTSW |
15 |
77,836,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9612:Foxred2
|
UTSW |
15 |
77,836,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Foxred2
|
UTSW |
15 |
77,836,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-11-18 |
Incidental Mutation