Incidental Mutation 'IGL01481:Olfr981'
ID88609
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr981
Ensembl Gene ENSMUSG00000046678
Gene Nameolfactory receptor 981
SynonymsMOR223-8, GA_x6K02T2PVTD-33720892-33721824
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.189) question?
Stock #IGL01481
Quality Score
Status
Chromosome9
Chromosomal Location40021464-40030377 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 40023278 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 295 (M295T)
Ref Sequence ENSEMBL: ENSMUSP00000149436 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059859] [ENSMUST00000215956]
Predicted Effect possibly damaging
Transcript: ENSMUST00000059859
AA Change: M295T

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000057952
Gene: ENSMUSG00000046678
AA Change: M295T

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 1.4e-54 PFAM
Pfam:7tm_1 41 288 8.8e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215956
AA Change: M295T

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219526
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220338
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik A T 6: 91,933,098 S523C probably damaging Het
Apaf1 A T 10: 91,031,588 D798E possibly damaging Het
Arhgef7 G T 8: 11,815,256 V410L probably benign Het
Capn7 T C 14: 31,355,339 L338P probably damaging Het
Cldn17 A G 16: 88,506,583 V86A probably benign Het
Clec4a2 A G 6: 123,142,500 N237S probably benign Het
Cmtr1 T G 17: 29,698,657 I654S probably benign Het
Cryzl2 G A 1: 157,470,739 probably null Het
Ctif A G 18: 75,611,784 probably benign Het
Dcaf7 T A 11: 106,054,746 I307N probably damaging Het
Drosha A T 15: 12,842,439 T399S probably benign Het
Eef2k A T 7: 120,895,218 Y35F probably benign Het
Emc1 T C 4: 139,362,099 S193P probably benign Het
Fpr2 T C 17: 17,892,763 I7T probably benign Het
Fras1 C A 5: 96,657,241 N1247K probably damaging Het
Gipr T C 7: 19,159,506 probably benign Het
Heatr5a C T 12: 51,955,425 G243S probably damaging Het
Hivep2 G A 10: 14,149,237 R2265Q probably benign Het
Iars T C 13: 49,728,698 S1073P probably benign Het
Inpp4b T C 8: 81,997,380 S514P probably damaging Het
Inpp5b T A 4: 124,800,699 probably null Het
Itga2 C T 13: 114,859,632 V708I possibly damaging Het
Itih5 A C 2: 10,190,289 Q164P probably damaging Het
Map3k19 T A 1: 127,822,478 E1045D probably damaging Het
Mbd5 T C 2: 49,278,939 V1374A possibly damaging Het
Mrps34 T C 17: 24,897,336 probably benign Het
Nadsyn1 T C 7: 143,812,584 D191G probably damaging Het
Nlrc3 T G 16: 3,963,905 N563H probably damaging Het
Nlrp4c T C 7: 6,100,784 C906R possibly damaging Het
Olfr1252 A G 2: 89,721,526 L195P probably damaging Het
Olfr344 T A 2: 36,568,742 L48H probably damaging Het
Olfr654 C A 7: 104,587,860 P36T probably damaging Het
Pdgfd C A 9: 6,337,271 T195K probably null Het
Ptprz1 C A 6: 22,999,980 Q690K probably benign Het
Scfd1 T A 12: 51,384,120 M23K probably damaging Het
Scn10a G A 9: 119,609,194 R1869C probably damaging Het
Scp2 T C 4: 108,074,442 probably null Het
Sec61a1 A G 6: 88,506,847 V354A probably benign Het
Sgpp1 T C 12: 75,722,657 I246V probably benign Het
Slco2a1 G T 9: 103,070,251 D250Y probably damaging Het
Slit2 A G 5: 48,302,931 N1435D probably benign Het
Sspo A G 6: 48,448,515 I23M probably benign Het
Steap4 A T 5: 7,976,858 T274S probably damaging Het
Tbc1d22b T C 17: 29,568,598 L107P possibly damaging Het
Tiparp G T 3: 65,552,609 G442* probably null Het
Tmem45a2 T A 16: 57,047,012 I109F probably benign Het
Top2a A T 11: 99,011,030 L458Q probably damaging Het
Tox T A 4: 6,842,396 T45S probably damaging Het
Vmn2r4 A T 3: 64,406,395 N388K probably damaging Het
Wdr7 G A 18: 63,739,179 D395N probably damaging Het
Other mutations in Olfr981
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02089:Olfr981 APN 9 40022770 missense probably damaging 1.00
R0722:Olfr981 UTSW 9 40022999 missense probably damaging 1.00
R1117:Olfr981 UTSW 9 40022762 missense probably damaging 0.99
R1781:Olfr981 UTSW 9 40023245 missense probably damaging 1.00
R1874:Olfr981 UTSW 9 40022855 missense possibly damaging 0.86
R1893:Olfr981 UTSW 9 40022974 missense possibly damaging 0.64
R1942:Olfr981 UTSW 9 40022735 missense probably damaging 1.00
R1942:Olfr981 UTSW 9 40022752 missense probably damaging 1.00
R1999:Olfr981 UTSW 9 40022689 missense probably benign
R2000:Olfr981 UTSW 9 40022689 missense probably benign
R2173:Olfr981 UTSW 9 40023254 missense probably damaging 0.97
R2760:Olfr981 UTSW 9 40022396 start codon destroyed probably null 0.00
R4300:Olfr981 UTSW 9 40023139 missense probably benign 0.02
R4530:Olfr981 UTSW 9 40023293 missense probably benign
R4614:Olfr981 UTSW 9 40022959 missense probably damaging 1.00
R4661:Olfr981 UTSW 9 40022527 missense probably damaging 1.00
R4777:Olfr981 UTSW 9 40022698 missense possibly damaging 0.90
R5017:Olfr981 UTSW 9 40022376 start gained probably benign
R5065:Olfr981 UTSW 9 40023250 missense probably benign 0.44
R5467:Olfr981 UTSW 9 40022437 missense probably benign 0.00
R5668:Olfr981 UTSW 9 40022668 missense probably damaging 1.00
R5687:Olfr981 UTSW 9 40022435 missense probably damaging 1.00
R6432:Olfr981 UTSW 9 40022528 missense probably damaging 1.00
R6620:Olfr981 UTSW 9 40022929 missense probably damaging 1.00
R6992:Olfr981 UTSW 9 40022600 nonsense probably null
R7156:Olfr981 UTSW 9 40023230 missense probably benign 0.23
R7250:Olfr981 UTSW 9 40022754 nonsense probably null
R7273:Olfr981 UTSW 9 40022665 missense probably benign 0.04
R8006:Olfr981 UTSW 9 40022474 missense probably damaging 1.00
Posted On2013-11-18