Incidental Mutation 'IGL01485:Or1e33'
ID 88707
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1e33
Ensembl Gene ENSMUSG00000094488
Gene Name olfactory receptor family 1 subfamily E member 33
Synonyms MOR135-7, GA_x6K02T2P1NL-4004140-4003208, Olfr393
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # IGL01485
Quality Score
Status
Chromosome 11
Chromosomal Location 73738011-73738949 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73738036 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 305 (I305T)
Ref Sequence ENSEMBL: ENSMUSP00000150031 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102523] [ENSMUST00000213365]
AlphaFold Q8VGR6
Predicted Effect probably benign
Transcript: ENSMUST00000102523
AA Change: I305T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000099582
Gene: ENSMUSG00000094488
AA Change: I305T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.5e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.3e-7 PFAM
Pfam:7tm_1 41 290 4.8e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213365
AA Change: I305T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik C T 6: 91,927,003 (GRCm39) L888F probably damaging Het
Aftph G T 11: 20,642,507 (GRCm39) A842E probably damaging Het
Ankrd13d A T 19: 4,323,592 (GRCm39) M257K probably benign Het
Anks1 T C 17: 28,270,558 (GRCm39) F786L probably damaging Het
Cd2ap A T 17: 43,163,365 (GRCm39) I20N probably damaging Het
Cdh20 C T 1: 104,861,832 (GRCm39) T4M probably benign Het
Dnah5 C T 15: 28,331,872 (GRCm39) R2153C probably damaging Het
Fap G A 2: 62,374,655 (GRCm39) P248L possibly damaging Het
Hps4 T A 5: 112,512,377 (GRCm39) probably benign Het
Igdcc4 C A 9: 65,029,889 (GRCm39) T313K probably benign Het
Klhl30 G A 1: 91,281,761 (GRCm39) V121I probably damaging Het
Ldb3 C A 14: 34,264,519 (GRCm39) E526D probably damaging Het
Ldc1 T A 4: 130,109,218 (GRCm39) Y274F probably benign Het
Lhfpl4 T A 6: 113,171,082 (GRCm39) I35F probably benign Het
Lpin1 A G 12: 16,612,358 (GRCm39) probably benign Het
Nek1 T A 8: 61,502,860 (GRCm39) C436S probably benign Het
Nek5 C A 8: 22,573,385 (GRCm39) A524S probably benign Het
Nkx2-3 C T 19: 43,601,094 (GRCm39) T52M possibly damaging Het
Or2w2 A T 13: 21,758,627 (GRCm39) probably null Het
Or8b56 G A 9: 38,739,895 (GRCm39) V303I possibly damaging Het
Pappa T C 4: 65,107,536 (GRCm39) V649A probably damaging Het
Parp4 T A 14: 56,859,661 (GRCm39) Y920N possibly damaging Het
Pdgfra G A 5: 75,324,313 (GRCm39) S56N probably benign Het
Pigg T C 5: 108,484,067 (GRCm39) V438A possibly damaging Het
Ptn A T 6: 36,720,298 (GRCm39) C85S probably damaging Het
Sh3rf1 A C 8: 61,782,365 (GRCm39) E169A possibly damaging Het
Slc30a10 T A 1: 185,187,616 (GRCm39) V119E probably damaging Het
Speg A G 1: 75,364,471 (GRCm39) E178G probably damaging Het
Sspo A G 6: 48,455,665 (GRCm39) Y3105C probably damaging Het
Supt3 A G 17: 45,430,045 (GRCm39) E366G possibly damaging Het
Top2a A T 11: 98,901,856 (GRCm39) L458Q probably damaging Het
Ttc21b G A 2: 66,082,234 (GRCm39) probably benign Het
Usp24 T C 4: 106,219,429 (GRCm39) F542L probably benign Het
Vmn1r234 T A 17: 21,449,171 (GRCm39) D28E possibly damaging Het
Other mutations in Or1e33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01845:Or1e33 APN 11 73,738,298 (GRCm39) missense probably damaging 1.00
IGL01969:Or1e33 APN 11 73,738,435 (GRCm39) missense possibly damaging 0.56
IGL02288:Or1e33 APN 11 73,738,207 (GRCm39) missense possibly damaging 0.88
IGL02726:Or1e33 APN 11 73,738,691 (GRCm39) missense probably benign 0.02
R0400:Or1e33 UTSW 11 73,738,867 (GRCm39) missense probably benign 0.15
R1672:Or1e33 UTSW 11 73,738,781 (GRCm39) missense probably benign 0.31
R1816:Or1e33 UTSW 11 73,738,025 (GRCm39) missense probably benign 0.00
R2294:Or1e33 UTSW 11 73,738,312 (GRCm39) missense probably damaging 1.00
R4506:Or1e33 UTSW 11 73,738,521 (GRCm39) nonsense probably null
R4587:Or1e33 UTSW 11 73,738,045 (GRCm39) missense probably benign 0.12
R4593:Or1e33 UTSW 11 73,738,140 (GRCm39) missense probably benign 0.22
R5216:Or1e33 UTSW 11 73,738,262 (GRCm39) missense probably damaging 0.97
R5657:Or1e33 UTSW 11 73,738,366 (GRCm39) missense probably damaging 1.00
R5763:Or1e33 UTSW 11 73,738,693 (GRCm39) missense probably benign 0.01
R5912:Or1e33 UTSW 11 73,738,501 (GRCm39) missense possibly damaging 0.61
R6025:Or1e33 UTSW 11 73,738,745 (GRCm39) missense probably benign 0.23
R6630:Or1e33 UTSW 11 73,738,702 (GRCm39) missense probably benign
R6804:Or1e33 UTSW 11 73,738,240 (GRCm39) missense probably benign 0.00
R7363:Or1e33 UTSW 11 73,738,741 (GRCm39) missense probably damaging 1.00
R7860:Or1e33 UTSW 11 73,738,333 (GRCm39) missense probably benign 0.07
R8103:Or1e33 UTSW 11 73,738,735 (GRCm39) missense probably damaging 1.00
R8158:Or1e33 UTSW 11 73,738,697 (GRCm39) missense probably benign 0.01
R8835:Or1e33 UTSW 11 73,738,702 (GRCm39) missense probably benign
R8925:Or1e33 UTSW 11 73,738,406 (GRCm39) missense probably benign 0.03
R8927:Or1e33 UTSW 11 73,738,406 (GRCm39) missense probably benign 0.03
R8960:Or1e33 UTSW 11 73,738,167 (GRCm39) nonsense probably null
R9221:Or1e33 UTSW 11 73,738,108 (GRCm39) missense probably damaging 1.00
R9355:Or1e33 UTSW 11 73,738,643 (GRCm39) missense probably damaging 0.98
R9502:Or1e33 UTSW 11 73,738,825 (GRCm39) missense probably damaging 1.00
Z1177:Or1e33 UTSW 11 73,738,627 (GRCm39) missense probably benign 0.23
Posted On 2013-11-18