Incidental Mutation 'IGL01487:Serpinb11'
ID88769
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Serpinb11
Ensembl Gene ENSMUSG00000026327
Gene Nameserine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
Synonyms2310046M08Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01487
Quality Score
Status
Chromosome1
Chromosomal Location107361198-107380475 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 107379838 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 333 (Y333F)
Ref Sequence ENSEMBL: ENSMUSP00000027566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027566]
Predicted Effect probably benign
Transcript: ENSMUST00000027566
AA Change: Y333F

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000027566
Gene: ENSMUSG00000026327
AA Change: Y333F

DomainStartEndE-ValueType
SERPIN 13 388 4.33e-143 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb1 A G 6: 88,839,449 V121A probably damaging Het
Carf A G 1: 60,109,379 H17R probably damaging Het
Col5a2 T C 1: 45,376,739 N1416S probably benign Het
Ctsm C A 13: 61,539,069 R3L probably benign Het
Dnah3 G A 7: 119,965,530 Q2626* probably null Het
Dpp3 C T 19: 4,913,892 V587I probably benign Het
Fank1 A G 7: 133,879,909 T245A probably damaging Het
Golga5 A G 12: 102,495,696 probably benign Het
Hoxb9 C T 11: 96,274,788 Q228* probably null Het
Invs A G 4: 48,398,136 I441V probably benign Het
Olfr344 T A 2: 36,568,742 L48H probably damaging Het
Psd3 T C 8: 67,697,114 E1243G probably benign Het
Rapgefl1 C T 11: 98,847,135 H392Y probably damaging Het
Ropn1 T C 16: 34,678,469 V209A probably damaging Het
Scap G A 9: 110,377,734 probably null Het
Scn5a A G 9: 119,562,623 M1T probably null Het
Sf3b3 A G 8: 110,817,660 Y783H probably benign Het
Slc4a4 A G 5: 89,228,856 M990V probably benign Het
Syt3 G T 7: 44,390,999 V219F possibly damaging Het
Tmtc4 A G 14: 122,926,031 L647S probably benign Het
Other mutations in Serpinb11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01893:Serpinb11 APN 1 107377657 missense probably benign
IGL01893:Serpinb11 APN 1 107377658 missense probably benign 0.01
IGL03011:Serpinb11 APN 1 107379816 missense probably damaging 1.00
IGL03126:Serpinb11 APN 1 107379924 missense probably damaging 1.00
R0138:Serpinb11 UTSW 1 107377530 missense probably damaging 1.00
R0153:Serpinb11 UTSW 1 107372203 missense probably benign 0.07
R0419:Serpinb11 UTSW 1 107376860 nonsense probably null
R1550:Serpinb11 UTSW 1 107379688 missense possibly damaging 0.94
R1764:Serpinb11 UTSW 1 107376802 missense probably benign 0.03
R1972:Serpinb11 UTSW 1 107369480 missense probably damaging 1.00
R3103:Serpinb11 UTSW 1 107377608 missense probably benign 0.07
R3768:Serpinb11 UTSW 1 107377662 critical splice donor site probably null
R4332:Serpinb11 UTSW 1 107369564 critical splice donor site probably null
R5001:Serpinb11 UTSW 1 107376868 missense possibly damaging 0.92
R5010:Serpinb11 UTSW 1 107379649 missense probably benign
R5043:Serpinb11 UTSW 1 107369465 missense probably damaging 0.97
R5186:Serpinb11 UTSW 1 107379754 missense probably damaging 1.00
R5833:Serpinb11 UTSW 1 107377662 critical splice donor site probably null
R5907:Serpinb11 UTSW 1 107372189 missense probably benign 0.12
R6244:Serpinb11 UTSW 1 107372242 missense probably damaging 0.99
R6395:Serpinb11 UTSW 1 107372051 intron probably null
R7111:Serpinb11 UTSW 1 107376884 missense probably benign 0.00
R7354:Serpinb11 UTSW 1 107377533 missense probably benign 0.03
R7664:Serpinb11 UTSW 1 107379988 missense probably damaging 1.00
Posted On2013-11-18