Incidental Mutation 'IGL00091:Dnajc22'
ID889
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dnajc22
Ensembl Gene ENSMUSG00000038009
Gene NameDnaJ heat shock protein family (Hsp40) member C22
Synonyms2810451A06Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.101) question?
Stock #IGL00091
Quality Score
Status
Chromosome15
Chromosomal Location99093170-99104737 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 99101178 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 81 (F81L)
Ref Sequence ENSEMBL: ENSMUSP00000055482 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061295]
Predicted Effect possibly damaging
Transcript: ENSMUST00000061295
AA Change: F81L

PolyPhen 2 Score 0.725 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000055482
Gene: ENSMUSG00000038009
AA Change: F81L

DomainStartEndE-ValueType
Pfam:TM2 1 50 1e-10 PFAM
transmembrane domain 76 98 N/A INTRINSIC
transmembrane domain 105 124 N/A INTRINSIC
transmembrane domain 139 161 N/A INTRINSIC
transmembrane domain 206 228 N/A INTRINSIC
DnaJ 276 335 1.09e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146173
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abraxas2 A T 7: 132,883,428 Y400F probably benign Het
Adamts8 C A 9: 30,953,500 T429K probably damaging Het
Adgrv1 C T 13: 81,578,101 D602N probably damaging Het
Ano7 A T 1: 93,402,166 H775L probably benign Het
Apoo-ps A T 13: 107,414,634 noncoding transcript Het
Arid2 T C 15: 96,372,302 V1432A probably benign Het
Atoh1 T C 6: 64,729,584 S88P possibly damaging Het
C130050O18Rik A G 5: 139,414,846 E218G probably damaging Het
Cacna2d1 T A 5: 16,212,944 F155L probably damaging Het
Car4 C T 11: 84,965,767 P294S probably damaging Het
Cyp1a2 G T 9: 57,682,069 S154* probably null Het
Cyp3a25 A T 5: 146,001,463 Y68* probably null Het
Dmbt1 C A 7: 131,079,540 probably benign Het
Eml5 G A 12: 98,873,209 probably benign Het
Fpgs A T 2: 32,686,547 probably benign Het
Gab2 T C 7: 97,302,443 S537P possibly damaging Het
Gmds G A 13: 32,234,390 S37L probably damaging Het
Ipo13 T C 4: 117,903,405 E626G probably benign Het
Kcng1 T C 2: 168,268,764 H160R probably benign Het
Lama3 A G 18: 12,580,292 T1608A probably benign Het
Lama4 A C 10: 39,072,805 S855R probably damaging Het
Ltbp1 C T 17: 75,225,338 H454Y probably damaging Het
Map3k14 C A 11: 103,227,579 G594C probably damaging Het
Mcph1 A G 8: 18,632,620 N591S possibly damaging Het
Moxd1 G A 10: 24,279,864 V289I probably damaging Het
Mptx2 T G 1: 173,274,888 N78T probably damaging Het
Muc4 G A 16: 32,754,086 G1321R probably benign Het
Muc6 A C 7: 141,638,584 S2059A probably benign Het
Nup50 T A 15: 84,935,404 F293Y probably benign Het
Ogn A G 13: 49,621,038 Y219C probably damaging Het
Pdia3 T C 2: 121,414,178 L47P probably damaging Het
Piwil4 A T 9: 14,703,097 D786E probably damaging Het
Pspc1 A G 14: 56,771,711 L222P probably damaging Het
Ptchd3 T A 11: 121,831,146 Y282N probably damaging Het
Reln C A 5: 22,039,565 G805V possibly damaging Het
Serpini2 T C 3: 75,249,242 Y327C probably damaging Het
Spire2 A G 8: 123,354,059 D14G probably damaging Het
Stab2 A T 10: 86,869,206 probably null Het
Timeless T C 10: 128,241,708 L219P probably damaging Het
Tmem63a C T 1: 180,963,088 T437M probably damaging Het
Tslp A G 18: 32,815,395 probably benign Het
Ttbk2 C A 2: 120,748,833 G534* probably null Het
Uggt1 T C 1: 36,179,552 probably benign Het
Vmn2r118 T C 17: 55,592,708 E732G probably damaging Het
Zfhx2 G A 14: 55,066,565 P1321S possibly damaging Het
Zfp58 A G 13: 67,490,995 V459A probably benign Het
Zfp831 T C 2: 174,645,658 S709P possibly damaging Het
Other mutations in Dnajc22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00922:Dnajc22 APN 15 99101579 missense possibly damaging 0.89
IGL02155:Dnajc22 APN 15 99101005 missense probably damaging 1.00
IGL02726:Dnajc22 APN 15 99101000 missense probably damaging 1.00
IGL03074:Dnajc22 APN 15 99101522 missense probably damaging 1.00
F5770:Dnajc22 UTSW 15 99101482 missense probably damaging 0.99
R1138:Dnajc22 UTSW 15 99104427 small deletion probably benign
R1628:Dnajc22 UTSW 15 99100936 start codon destroyed probably null 1.00
R2018:Dnajc22 UTSW 15 99101233 missense probably benign 0.06
R2146:Dnajc22 UTSW 15 99104383 missense probably benign 0.04
R4342:Dnajc22 UTSW 15 99104464 nonsense probably null
R4950:Dnajc22 UTSW 15 99101734 missense probably benign 0.29
R7123:Dnajc22 UTSW 15 99101204 missense possibly damaging 0.89
R7173:Dnajc22 UTSW 15 99101306 missense probably benign 0.06
R7640:Dnajc22 UTSW 15 99101114 missense probably damaging 1.00
R7997:Dnajc22 UTSW 15 99101633 missense probably damaging 1.00
R8338:Dnajc22 UTSW 15 99101141 missense probably benign 0.00
V7580:Dnajc22 UTSW 15 99101482 missense probably damaging 0.99
V7581:Dnajc22 UTSW 15 99101482 missense probably damaging 0.99
V7582:Dnajc22 UTSW 15 99101482 missense probably damaging 0.99
V7583:Dnajc22 UTSW 15 99101482 missense probably damaging 0.99
Posted On2011-07-12