Incidental Mutation 'IGL01503:Gm436'
ID88941
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm436
Ensembl Gene ENSMUSG00000078505
Gene Namepredicted gene 436
SynonymsLOC230890
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.050) question?
Stock #IGL01503
Quality Score
Status
Chromosome4
Chromosomal Location144669937-144686368 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 144674567 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 116 (I116F)
Ref Sequence ENSEMBL: ENSMUSP00000101373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105747]
Predicted Effect probably damaging
Transcript: ENSMUST00000105747
AA Change: I116F

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000101373
Gene: ENSMUSG00000078505
AA Change: I116F

DomainStartEndE-ValueType
transmembrane domain 2 24 N/A INTRINSIC
Pfam:Abhydrolase_3 115 285 1.6e-29 PFAM
Pfam:Abhydrolase_3 292 381 9e-12 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110057P08Rik T A 16: 89,174,869 Y26* probably null Het
Arpc1a T C 5: 145,096,154 V91A probably damaging Het
Atp2a1 T A 7: 126,448,578 I687F probably damaging Het
B3gnt5 A C 16: 19,769,781 Y250S probably damaging Het
Brip1 A G 11: 86,061,877 V1026A probably benign Het
C1s2 T C 6: 124,625,653 D527G probably damaging Het
Chrna5 T A 9: 54,998,171 probably benign Het
Cltc C A 11: 86,695,700 probably benign Het
Dgkh T G 14: 78,616,270 I439L possibly damaging Het
Dnajc16 G A 4: 141,763,697 T714I possibly damaging Het
Fam13a A T 6: 58,956,080 I349N probably damaging Het
Fig4 C T 10: 41,256,518 D431N probably benign Het
Gabra4 A T 5: 71,641,086 N183K possibly damaging Het
Ggt5 C T 10: 75,610,110 probably benign Het
Hdac6 A G X: 7,932,179 L798P probably damaging Het
Hectd4 T C 5: 121,318,651 V2030A probably benign Het
Hecw2 A G 1: 53,826,961 Y1514H probably damaging Het
Hmcn1 T C 1: 150,605,072 D4451G probably benign Het
Krtcap3 T C 5: 31,251,823 probably benign Het
Ltn1 A T 16: 87,420,807 probably benign Het
Mapkapk2 T C 1: 131,058,762 M1V probably null Het
Mical3 A T 6: 120,958,576 I1663N probably benign Het
Mvp G T 7: 127,001,961 probably benign Het
Myo5c A G 9: 75,263,042 I485V probably damaging Het
N4bp2 T A 5: 65,803,547 C520* probably null Het
Nos2 A G 11: 78,945,863 probably benign Het
Ogdh G A 11: 6,355,069 V925M probably damaging Het
Pde2a T A 7: 101,501,936 probably benign Het
Plpp6 A G 19: 28,964,879 *293W probably null Het
Pole T A 5: 110,303,884 I864K probably damaging Het
Rexo4 A T 2: 26,960,633 I239N probably benign Het
Scn1a T A 2: 66,322,343 I748F probably damaging Het
Sfmbt2 A T 2: 10,579,354 R841* probably null Het
Sh3bp5l A G 11: 58,338,001 N100S probably damaging Het
Spic T A 10: 88,675,761 D211V probably damaging Het
Stab2 A G 10: 86,940,613 probably benign Het
Tshr A G 12: 91,511,934 Y83C probably damaging Het
Vsir A G 10: 60,368,594 E172G probably damaging Het
Wwp2 T C 8: 107,549,781 S508P probably damaging Het
Other mutations in Gm436
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01149:Gm436 APN 4 144673779 missense probably benign 0.12
IGL01369:Gm436 APN 4 144674645 missense possibly damaging 0.50
IGL01505:Gm436 APN 4 144674618 missense probably damaging 1.00
IGL01954:Gm436 APN 4 144670171 missense probably damaging 1.00
IGL02447:Gm436 APN 4 144674699 missense probably benign 0.02
IGL02804:Gm436 APN 4 144670439 missense possibly damaging 0.95
R0373:Gm436 UTSW 4 144686220 missense possibly damaging 0.54
R1124:Gm436 UTSW 4 144670275 missense probably benign 0.00
R1598:Gm436 UTSW 4 144670424 missense possibly damaging 0.60
R1734:Gm436 UTSW 4 144670026 missense probably benign 0.04
R1763:Gm436 UTSW 4 144669959 missense probably benign 0.24
R1968:Gm436 UTSW 4 144670623 missense possibly damaging 0.83
R3055:Gm436 UTSW 4 144674698 missense probably benign 0.16
R3056:Gm436 UTSW 4 144674698 missense probably benign 0.16
R3930:Gm436 UTSW 4 144670128 missense probably damaging 1.00
R5124:Gm436 UTSW 4 144674719 missense probably damaging 1.00
R5407:Gm436 UTSW 4 144670325 missense probably benign 0.01
R6302:Gm436 UTSW 4 144670190 nonsense probably null
R6814:Gm436 UTSW 4 144670646 nonsense probably null
R6872:Gm436 UTSW 4 144670646 nonsense probably null
R6988:Gm436 UTSW 4 144686325 missense probably benign 0.01
R7131:Gm436 UTSW 4 144670067 missense probably damaging 0.98
R7895:Gm436 UTSW 4 144670343 missense possibly damaging 0.95
R8108:Gm436 UTSW 4 144670669 missense probably benign 0.04
R8378:Gm436 UTSW 4 144670599 missense probably benign 0.24
R8676:Gm436 UTSW 4 144670113 missense possibly damaging 0.94
R8817:Gm436 UTSW 4 144673791 missense probably benign 0.00
Posted On2013-12-03