Incidental Mutation 'IGL01505:Olfr890'
ID89002
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr890
Ensembl Gene ENSMUSG00000096409
Gene Nameolfactory receptor 890
SynonymsMOR162-3, MOR162-15_p, GA_x6K02T2PVTD-31822365-31823309
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL01505
Quality Score
Status
Chromosome9
Chromosomal Location38142517-38148375 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 38143871 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 240 (C240*)
Ref Sequence ENSEMBL: ENSMUSP00000149829 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079804] [ENSMUST00000213087] [ENSMUST00000213458]
Predicted Effect probably null
Transcript: ENSMUST00000079804
AA Change: C245*
SMART Domains Protein: ENSMUSP00000078733
Gene: ENSMUSG00000096409
AA Change: C245*

DomainStartEndE-ValueType
Pfam:7tm_4 36 311 2.3e-48 PFAM
Pfam:7tm_1 46 293 9.6e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213087
AA Change: C240*
Predicted Effect probably null
Transcript: ENSMUST00000213458
AA Change: C240*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930546C10Rik T C 18: 68,947,347 probably null Het
A2m A G 6: 121,676,947 N1413S possibly damaging Het
Arhgap45 A T 10: 80,026,542 N488Y probably benign Het
Arid4a G A 12: 71,037,115 D94N probably damaging Het
Atp7a A G X: 106,109,830 K1114E probably damaging Het
Atp8a2 C T 14: 60,028,063 V275M probably benign Het
Ceacam12 T C 7: 18,067,432 V112A probably damaging Het
Cep295 T A 9: 15,318,049 D2256V probably benign Het
Chid1 A T 7: 141,513,894 probably null Het
Clcn5 A T X: 7,170,439 L268* probably null Het
Cldn17 A G 16: 88,506,703 I46T possibly damaging Het
Cnot1 A T 8: 95,728,718 I2025N probably damaging Het
Cntn5 C T 9: 9,706,087 V574M probably damaging Het
Col14a1 T A 15: 55,455,223 C1373S unknown Het
Col9a1 A G 1: 24,185,124 N129S unknown Het
Cp C T 3: 19,977,192 P598S possibly damaging Het
Cpb1 G A 3: 20,266,246 R150C probably damaging Het
Cyp2j7 T A 4: 96,227,680 probably null Het
Dnajb7 T C 15: 81,407,491 E215G possibly damaging Het
Dock1 G A 7: 135,158,510 R1634Q possibly damaging Het
Dopey2 A G 16: 93,757,116 T313A possibly damaging Het
Fgd2 T A 17: 29,366,997 V185E probably damaging Het
Flnb T C 14: 7,902,003 probably null Het
Fzd7 A G 1: 59,483,903 E315G probably benign Het
Gjc1 T A 11: 102,800,726 K150N probably benign Het
Gm436 C T 4: 144,674,618 V99M probably damaging Het
Gpihbp1 C T 15: 75,598,128 probably benign Het
Gpr160 T C 3: 30,895,853 S25P possibly damaging Het
Grsf1 G A 5: 88,672,749 R58* probably null Het
Ifit1 T A 19: 34,648,454 M330K probably benign Het
Igkv1-122 T C 6: 68,017,194 V22A probably benign Het
Ikbke A T 1: 131,255,311 D692E probably benign Het
Il15ra T C 2: 11,733,145 probably benign Het
Il18rap A G 1: 40,537,084 I252V probably damaging Het
Klra10 C T 6: 130,272,717 G202R probably damaging Het
Kpna7 A G 5: 144,992,851 V388A probably damaging Het
L2hgdh A G 12: 69,721,401 S108P probably damaging Het
Msto1 G A 3: 88,910,743 T388M probably benign Het
Naip1 T C 13: 100,425,933 E908G probably damaging Het
Neto1 C A 18: 86,473,689 D238E possibly damaging Het
Nlrp5 T A 7: 23,417,734 D294E probably benign Het
Nr3c2 T C 8: 76,909,187 S306P probably damaging Het
Pard3 T A 8: 127,324,063 L202H probably damaging Het
Pdzd2 T C 15: 12,458,207 N190S probably damaging Het
Pi4ka T C 16: 17,309,358 D1077G probably benign Het
Pmfbp1 A C 8: 109,513,911 L208F probably damaging Het
Pms1 C T 1: 53,206,971 D470N probably benign Het
Prdm10 T C 9: 31,327,282 F108L probably benign Het
Rab11fip1 A T 8: 27,154,776 M327K possibly damaging Het
Slc37a4 T A 9: 44,399,964 L184Q probably damaging Het
Smdt1 T C 15: 82,347,893 probably benign Het
Smg6 A G 11: 75,156,291 Y1270C probably damaging Het
Speer4f2 T A 5: 17,376,567 V169E possibly damaging Het
Stpg2 C T 3: 139,317,453 A410V probably benign Het
Tnrc6b T A 15: 80,879,963 D555E probably benign Het
Tsg101 A G 7: 46,909,060 Y46H probably damaging Het
Vmn2r111 G A 17: 22,548,572 S648L probably benign Het
Vmn2r73 T A 7: 85,858,059 R682* probably null Het
Xkr5 A T 8: 18,933,498 I676N probably damaging Het
Other mutations in Olfr890
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01861:Olfr890 APN 9 38143750 missense probably damaging 1.00
IGL02174:Olfr890 APN 9 38143785 missense possibly damaging 0.90
IGL02723:Olfr890 APN 9 38143411 missense probably benign 0.02
IGL03085:Olfr890 APN 9 38143183 missense probably damaging 0.98
FR4449:Olfr890 UTSW 9 38143188 missense probably benign 0.00
FR4737:Olfr890 UTSW 9 38143188 missense probably benign 0.00
R0637:Olfr890 UTSW 9 38143882 missense probably benign 0.00
R1353:Olfr890 UTSW 9 38143728 missense probably benign 0.03
R1813:Olfr890 UTSW 9 38143729 missense possibly damaging 0.78
R5997:Olfr890 UTSW 9 38143801 missense probably damaging 1.00
R6004:Olfr890 UTSW 9 38143960 missense probably damaging 1.00
R6417:Olfr890 UTSW 9 38143315 missense probably damaging 1.00
R6420:Olfr890 UTSW 9 38143315 missense probably damaging 1.00
R6720:Olfr890 UTSW 9 38143153 start codon destroyed probably null 1.00
R7223:Olfr890 UTSW 9 38143753 missense probably benign 0.02
R7601:Olfr890 UTSW 9 38143378 missense probably benign 0.13
R7671:Olfr890 UTSW 9 38143440 missense probably benign 0.02
R8034:Olfr890 UTSW 9 38143677 missense probably damaging 1.00
R8356:Olfr890 UTSW 9 38143685 nonsense probably null
R8456:Olfr890 UTSW 9 38143685 nonsense probably null
Z1176:Olfr890 UTSW 9 38143431 missense probably benign 0.02
Posted On2013-12-03