Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01505:Or8b41'

89002

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8b41

Ensembl Gene

ENSMUSG00000096409

Gene Name

olfactory receptor family 8 subfamily B member 41

Synonyms

Olfr890, MOR162-15_p, MOR162-3, GA_x6K02T2PVTD-31822365-31823309

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL01505

Quality Score

Status

Chromosome

Chromosomal Location

38054433-38055377 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 38055167 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 240 (C240*)

Ref Sequence

ENSEMBL: ENSMUSP00000149829 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079804] [ENSMUST00000213087] [ENSMUST00000213458]

AlphaFold

Q7TRD9

Predicted Effect

probably null
Transcript: ENSMUST00000079804
AA Change: C245*

SMART Domains

Protein: ENSMUSP00000078733
Gene: ENSMUSG00000096409
AA Change: C245*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	36	311	2.3e-48	PFAM
Pfam:7tm_1	46	293	9.6e-25	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213087
AA Change: C240*

Predicted Effect

probably null
Transcript: ENSMUST00000213458
AA Change: C240*

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930546C10Rik	T	C	18: 69,080,418 (GRCm39)		probably null	Het
A2m	A	G	6: 121,653,906 (GRCm39)	N1413S	possibly damaging	Het
Aadacl4fm4	C	T	4: 144,401,188 (GRCm39)	V99M	probably damaging	Het
Arhgap45	A	T	10: 79,862,376 (GRCm39)	N488Y	probably benign	Het
Arid4a	G	A	12: 71,083,889 (GRCm39)	D94N	probably damaging	Het
Atp7a	A	G	X: 105,153,436 (GRCm39)	K1114E	probably damaging	Het
Atp8a2	C	T	14: 60,265,512 (GRCm39)	V275M	probably benign	Het
Ceacam12	T	C	7: 17,801,357 (GRCm39)	V112A	probably damaging	Het
Cep295	T	A	9: 15,229,345 (GRCm39)	D2256V	probably benign	Het
Chid1	A	T	7: 141,093,807 (GRCm39)		probably null	Het
Clcn5	A	T	X: 7,036,678 (GRCm39)	L268*	probably null	Het
Cldn17	A	G	16: 88,303,591 (GRCm39)	I46T	possibly damaging	Het
Cnot1	A	T	8: 96,455,346 (GRCm39)	I2025N	probably damaging	Het
Cntn5	C	T	9: 9,706,092 (GRCm39)	V574M	probably damaging	Het
Col14a1	T	A	15: 55,318,619 (GRCm39)	C1373S	unknown	Het
Col9a1	A	G	1: 24,224,205 (GRCm39)	N129S	unknown	Het
Cp	C	T	3: 20,031,356 (GRCm39)	P598S	possibly damaging	Het
Cpb1	G	A	3: 20,320,410 (GRCm39)	R150C	probably damaging	Het
Cyp2j7	T	A	4: 96,115,917 (GRCm39)		probably null	Het
Dnajb7	T	C	15: 81,291,692 (GRCm39)	E215G	possibly damaging	Het
Dock1	G	A	7: 134,760,239 (GRCm39)	R1634Q	possibly damaging	Het
Dop1b	A	G	16: 93,554,004 (GRCm39)	T313A	possibly damaging	Het
Fgd2	T	A	17: 29,585,971 (GRCm39)	V185E	probably damaging	Het
Flnb	T	C	14: 7,902,003 (GRCm38)		probably null	Het
Fzd7	A	G	1: 59,523,062 (GRCm39)	E315G	probably benign	Het
Gjd3	T	A	11: 102,691,552 (GRCm39)	K150N	probably benign	Het
Gpihbp1	C	T	15: 75,469,977 (GRCm39)		probably benign	Het
Gpr160	T	C	3: 30,950,002 (GRCm39)	S25P	possibly damaging	Het
Grsf1	G	A	5: 88,820,608 (GRCm39)	R58*	probably null	Het
Ifit1	T	A	19: 34,625,854 (GRCm39)	M330K	probably benign	Het
Igkv1-122	T	C	6: 67,994,178 (GRCm39)	V22A	probably benign	Het
Ikbke	A	T	1: 131,183,048 (GRCm39)	D692E	probably benign	Het
Il15ra	T	C	2: 11,737,956 (GRCm39)		probably benign	Het
Il18rap	A	G	1: 40,576,244 (GRCm39)	I252V	probably damaging	Het
Klra10	C	T	6: 130,249,680 (GRCm39)	G202R	probably damaging	Het
Kpna7	A	G	5: 144,929,661 (GRCm39)	V388A	probably damaging	Het
L2hgdh	A	G	12: 69,768,175 (GRCm39)	S108P	probably damaging	Het
Msto1	G	A	3: 88,818,050 (GRCm39)	T388M	probably benign	Het
Naip1	T	C	13: 100,562,441 (GRCm39)	E908G	probably damaging	Het
Neto1	C	A	18: 86,491,814 (GRCm39)	D238E	possibly damaging	Het
Nlrp5	T	A	7: 23,117,159 (GRCm39)	D294E	probably benign	Het
Nr3c2	T	C	8: 77,635,816 (GRCm39)	S306P	probably damaging	Het
Pard3	T	A	8: 128,050,544 (GRCm39)	L202H	probably damaging	Het
Pdzd2	T	C	15: 12,458,293 (GRCm39)	N190S	probably damaging	Het
Pi4ka	T	C	16: 17,127,222 (GRCm39)	D1077G	probably benign	Het
Pmfbp1	A	C	8: 110,240,543 (GRCm39)	L208F	probably damaging	Het
Pms1	C	T	1: 53,246,130 (GRCm39)	D470N	probably benign	Het
Prdm10	T	C	9: 31,238,578 (GRCm39)	F108L	probably benign	Het
Rab11fip1	A	T	8: 27,644,804 (GRCm39)	M327K	possibly damaging	Het
Slc37a4	T	A	9: 44,311,261 (GRCm39)	L184Q	probably damaging	Het
Smdt1	T	C	15: 82,232,094 (GRCm39)		probably benign	Het
Smg6	A	G	11: 75,047,117 (GRCm39)	Y1270C	probably damaging	Het
Speer4f2	T	A	5: 17,581,565 (GRCm39)	V169E	possibly damaging	Het
Stpg2	C	T	3: 139,023,214 (GRCm39)	A410V	probably benign	Het
Tnrc6b	T	A	15: 80,764,164 (GRCm39)	D555E	probably benign	Het
Tsg101	A	G	7: 46,558,808 (GRCm39)	Y46H	probably damaging	Het
Vmn2r111	G	A	17: 22,767,553 (GRCm39)	S648L	probably benign	Het
Vmn2r73	T	A	7: 85,507,267 (GRCm39)	R682*	probably null	Het
Xkr5	A	T	8: 18,983,514 (GRCm39)	I676N	probably damaging	Het

Other mutations in Or8b41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01861:Or8b41	APN	9	38,055,046 (GRCm39)	missense	probably damaging	1.00
IGL02174:Or8b41	APN	9	38,055,081 (GRCm39)	missense	possibly damaging	0.90
IGL02723:Or8b41	APN	9	38,054,707 (GRCm39)	missense	probably benign	0.02
IGL03085:Or8b41	APN	9	38,054,479 (GRCm39)	missense	probably damaging	0.98
FR4449:Or8b41	UTSW	9	38,054,484 (GRCm39)	missense	probably benign	0.00
FR4737:Or8b41	UTSW	9	38,054,484 (GRCm39)	missense	probably benign	0.00
R0637:Or8b41	UTSW	9	38,055,178 (GRCm39)	missense	probably benign	0.00
R1353:Or8b41	UTSW	9	38,055,024 (GRCm39)	missense	probably benign	0.03
R1813:Or8b41	UTSW	9	38,055,025 (GRCm39)	missense	possibly damaging	0.78
R5997:Or8b41	UTSW	9	38,055,097 (GRCm39)	missense	probably damaging	1.00
R6004:Or8b41	UTSW	9	38,055,256 (GRCm39)	missense	probably damaging	1.00
R6417:Or8b41	UTSW	9	38,054,611 (GRCm39)	missense	probably damaging	1.00
R6420:Or8b41	UTSW	9	38,054,611 (GRCm39)	missense	probably damaging	1.00
R6720:Or8b41	UTSW	9	38,054,449 (GRCm39)	start codon destroyed	probably null	1.00
R7223:Or8b41	UTSW	9	38,055,049 (GRCm39)	missense	probably benign	0.02
R7601:Or8b41	UTSW	9	38,054,674 (GRCm39)	missense	probably benign	0.13
R7671:Or8b41	UTSW	9	38,054,736 (GRCm39)	missense	probably benign	0.02
R8034:Or8b41	UTSW	9	38,054,973 (GRCm39)	missense	probably damaging	1.00
R8356:Or8b41	UTSW	9	38,054,981 (GRCm39)	nonsense	probably null
R8456:Or8b41	UTSW	9	38,054,981 (GRCm39)	nonsense	probably null
R8696:Or8b41	UTSW	9	38,054,433 (GRCm39)	start codon destroyed	probably null	0.00
R9487:Or8b41	UTSW	9	38,054,866 (GRCm39)	missense	probably benign	0.22
R9517:Or8b41	UTSW	9	38,054,623 (GRCm39)	missense	probably damaging	1.00
Z1176:Or8b41	UTSW	9	38,054,727 (GRCm39)	missense	probably benign	0.02

Posted On

2013-12-03