Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01505:Grsf1'

89013

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Grsf1

Ensembl Gene

ENSMUSG00000044221

Gene Name

G-rich RNA sequence binding factor 1

Synonyms

D5Wsu31e

Accession Numbers

Genbank: NM_178700; MGI: 106479

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01505

Quality Score

Status

Chromosome

Chromosomal Location

88659448-88676171 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 88672749 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 58 (R58*)

Ref Sequence

ENSEMBL: ENSMUSP00000108860 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078945] [ENSMUST00000113234] [ENSMUST00000133532] [ENSMUST00000150438] [ENSMUST00000153565]

Predicted Effect

probably null
Transcript: ENSMUST00000078945
AA Change: R175*

SMART Domains

Protein: ENSMUSP00000077972
Gene: ENSMUSG00000044221
AA Change: R175*

Domain	Start	End	E-Value	Type
low complexity region	13	24	N/A	INTRINSIC
low complexity region	45	60	N/A	INTRINSIC
low complexity region	64	101	N/A	INTRINSIC
low complexity region	124	139	N/A	INTRINSIC
RRM	150	224	1.65e-6	SMART
RRM	250	321	1.79e-11	SMART
RRM	401	471	1.54e-6	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000113234
AA Change: R58*

SMART Domains

Protein: ENSMUSP00000108860
Gene: ENSMUSG00000044221
AA Change: R58*

Domain	Start	End	E-Value	Type
low complexity region	7	22	N/A	INTRINSIC
RRM	33	107	1.65e-6	SMART
RRM	133	204	1.79e-11	SMART
RRM	284	354	1.54e-6	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130408

Predicted Effect

probably benign
Transcript: ENSMUST00000133532

SMART Domains

Protein: ENSMUSP00000114732
Gene: ENSMUSG00000044221

Domain	Start	End	E-Value	Type
Blast:RRM	1	26	6e-11	BLAST
PDB:2LMI\|A	1	46	3e-26	PDB

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137725

Predicted Effect

probably benign
Transcript: ENSMUST00000150438

Predicted Effect

probably benign
Transcript: ENSMUST00000153565

SMART Domains

Protein: ENSMUSP00000123051
Gene: ENSMUSG00000044221

Domain	Start	End	E-Value	Type
internal_repeat_1	2	33	5.45e-5	PROSPERO
RRM	52	123	1.79e-11	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Allele List at MGI

All alleles(4) : Gene trapped(4)

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930546C10Rik	T	C	18: 68,947,347		probably null	Het
A2m	A	G	6: 121,676,947	N1413S	possibly damaging	Het
Arhgap45	A	T	10: 80,026,542	N488Y	probably benign	Het
Arid4a	G	A	12: 71,037,115	D94N	probably damaging	Het
Atp7a	A	G	X: 106,109,830	K1114E	probably damaging	Het
Atp8a2	C	T	14: 60,028,063	V275M	probably benign	Het
Ceacam12	T	C	7: 18,067,432	V112A	probably damaging	Het
Cep295	T	A	9: 15,318,049	D2256V	probably benign	Het
Chid1	A	T	7: 141,513,894		probably null	Het
Clcn5	A	T	X: 7,170,439	L268*	probably null	Het
Cldn17	A	G	16: 88,506,703	I46T	possibly damaging	Het
Cnot1	A	T	8: 95,728,718	I2025N	probably damaging	Het
Cntn5	C	T	9: 9,706,087	V574M	probably damaging	Het
Col14a1	T	A	15: 55,455,223	C1373S	unknown	Het
Col9a1	A	G	1: 24,185,124	N129S	unknown	Het
Cp	C	T	3: 19,977,192	P598S	possibly damaging	Het
Cpb1	G	A	3: 20,266,246	R150C	probably damaging	Het
Cyp2j7	T	A	4: 96,227,680		probably null	Het
Dnajb7	T	C	15: 81,407,491	E215G	possibly damaging	Het
Dock1	G	A	7: 135,158,510	R1634Q	possibly damaging	Het
Dopey2	A	G	16: 93,757,116	T313A	possibly damaging	Het
Fgd2	T	A	17: 29,366,997	V185E	probably damaging	Het
Flnb	T	C	14: 7,902,003		probably null	Het
Fzd7	A	G	1: 59,483,903	E315G	probably benign	Het
Gjc1	T	A	11: 102,800,726	K150N	probably benign	Het
Gm436	C	T	4: 144,674,618	V99M	probably damaging	Het
Gpihbp1	C	T	15: 75,598,128		probably benign	Het
Gpr160	T	C	3: 30,895,853	S25P	possibly damaging	Het
Ifit1	T	A	19: 34,648,454	M330K	probably benign	Het
Igkv1-122	T	C	6: 68,017,194	V22A	probably benign	Het
Ikbke	A	T	1: 131,255,311	D692E	probably benign	Het
Il15ra	T	C	2: 11,733,145		probably benign	Het
Il18rap	A	G	1: 40,537,084	I252V	probably damaging	Het
Klra10	C	T	6: 130,272,717	G202R	probably damaging	Het
Kpna7	A	G	5: 144,992,851	V388A	probably damaging	Het
L2hgdh	A	G	12: 69,721,401	S108P	probably damaging	Het
Msto1	G	A	3: 88,910,743	T388M	probably benign	Het
Naip1	T	C	13: 100,425,933	E908G	probably damaging	Het
Neto1	C	A	18: 86,473,689	D238E	possibly damaging	Het
Nlrp5	T	A	7: 23,417,734	D294E	probably benign	Het
Nr3c2	T	C	8: 76,909,187	S306P	probably damaging	Het
Olfr890	T	A	9: 38,143,871	C240*	probably null	Het
Pard3	T	A	8: 127,324,063	L202H	probably damaging	Het
Pdzd2	T	C	15: 12,458,207	N190S	probably damaging	Het
Pi4ka	T	C	16: 17,309,358	D1077G	probably benign	Het
Pmfbp1	A	C	8: 109,513,911	L208F	probably damaging	Het
Pms1	C	T	1: 53,206,971	D470N	probably benign	Het
Prdm10	T	C	9: 31,327,282	F108L	probably benign	Het
Rab11fip1	A	T	8: 27,154,776	M327K	possibly damaging	Het
Slc37a4	T	A	9: 44,399,964	L184Q	probably damaging	Het
Smdt1	T	C	15: 82,347,893		probably benign	Het
Smg6	A	G	11: 75,156,291	Y1270C	probably damaging	Het
Speer4f2	T	A	5: 17,376,567	V169E	possibly damaging	Het
Stpg2	C	T	3: 139,317,453	A410V	probably benign	Het
Tnrc6b	T	A	15: 80,879,963	D555E	probably benign	Het
Tsg101	A	G	7: 46,909,060	Y46H	probably damaging	Het
Vmn2r111	G	A	17: 22,548,572	S648L	probably benign	Het
Vmn2r73	T	A	7: 85,858,059	R682*	probably null	Het
Xkr5	A	T	8: 18,933,498	I676N	probably damaging	Het

Other mutations in Grsf1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00421:Grsf1	APN	5	88670278	missense	probably damaging	1.00
IGL02108:Grsf1	APN	5	88665903	missense	probably benign	0.35
IGL02116:Grsf1	APN	5	88670174	critical splice donor site	probably null
IGL02713:Grsf1	APN	5	88672730	missense	probably damaging	1.00
IGL02881:Grsf1	APN	5	88673830	missense	probably damaging	1.00
R0336:Grsf1	UTSW	5	88663153	missense	probably damaging	0.96
R1381:Grsf1	UTSW	5	88665864	missense	probably benign	0.10
R1398:Grsf1	UTSW	5	88665847	missense	probably benign	0.03
R2136:Grsf1	UTSW	5	88672658	missense	probably benign	0.05
R2398:Grsf1	UTSW	5	88673836	missense	probably damaging	1.00
R4181:Grsf1	UTSW	5	88664156	missense	probably benign	0.00
R4182:Grsf1	UTSW	5	88664156	missense	probably benign	0.00
R4183:Grsf1	UTSW	5	88664156	missense	probably benign	0.00
R4184:Grsf1	UTSW	5	88664156	missense	probably benign	0.00
R5315:Grsf1	UTSW	5	88673775	start gained	probably benign
R6246:Grsf1	UTSW	5	88662592	missense	possibly damaging	0.81
R7359:Grsf1	UTSW	5	88665564	splice site	probably null
R7381:Grsf1	UTSW	5	88665807	missense	probably benign	0.02
R7430:Grsf1	UTSW	5	88663227	missense	possibly damaging	0.67
R7703:Grsf1	UTSW	5	88671291	missense	probably damaging	1.00
R7838:Grsf1	UTSW	5	88675664	start gained	probably benign
R8013:Grsf1	UTSW	5	88675756	critical splice donor site	probably null
YA93:Grsf1	UTSW	5	88673735	missense	probably damaging	1.00

Posted On

2013-12-03