Incidental Mutation 'IGL01505:Gpr160'
ID 89017
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr160
Ensembl Gene ENSMUSG00000037661
Gene Name G protein-coupled receptor 160
Synonyms 1700025D19Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01505
Quality Score
Status
Chromosome 3
Chromosomal Location 30910099-30951341 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 30950002 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 25 (S25P)
Ref Sequence ENSEMBL: ENSMUSP00000128666 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046624] [ENSMUST00000046748] [ENSMUST00000108258] [ENSMUST00000108259] [ENSMUST00000108261] [ENSMUST00000147697] [ENSMUST00000166278] [ENSMUST00000194979] [ENSMUST00000168645]
AlphaFold Q3U3F9
Predicted Effect probably benign
Transcript: ENSMUST00000046624
SMART Domains Protein: ENSMUSP00000037862
Gene: ENSMUSG00000037652

DomainStartEndE-ValueType
low complexity region 18 40 N/A INTRINSIC
low complexity region 72 89 N/A INTRINSIC
low complexity region 92 142 N/A INTRINSIC
low complexity region 152 166 N/A INTRINSIC
low complexity region 206 224 N/A INTRINSIC
low complexity region 333 359 N/A INTRINSIC
low complexity region 393 419 N/A INTRINSIC
low complexity region 512 538 N/A INTRINSIC
low complexity region 564 578 N/A INTRINSIC
low complexity region 583 594 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000046748
AA Change: S25P

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000045165
Gene: ENSMUSG00000037661
AA Change: S25P

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000108258
AA Change: S25P

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000103893
Gene: ENSMUSG00000037661
AA Change: S25P

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000108259
AA Change: S25P

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000103894
Gene: ENSMUSG00000037661
AA Change: S25P

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000108261
AA Change: S25P

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000103896
Gene: ENSMUSG00000037661
AA Change: S25P

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000147697
Predicted Effect possibly damaging
Transcript: ENSMUST00000166278
AA Change: S25P

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000128666
Gene: ENSMUSG00000037661
AA Change: S25P

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000194979
Predicted Effect probably benign
Transcript: ENSMUST00000168645
SMART Domains Protein: ENSMUSP00000130142
Gene: ENSMUSG00000037652

DomainStartEndE-ValueType
low complexity region 6 28 N/A INTRINSIC
low complexity region 60 77 N/A INTRINSIC
low complexity region 80 130 N/A INTRINSIC
low complexity region 140 154 N/A INTRINSIC
low complexity region 194 212 N/A INTRINSIC
low complexity region 321 347 N/A INTRINSIC
low complexity region 381 407 N/A INTRINSIC
low complexity region 500 526 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
low complexity region 571 601 N/A INTRINSIC
low complexity region 640 648 N/A INTRINSIC
low complexity region 658 686 N/A INTRINSIC
PDB:2L8E|A 775 811 7e-9 PDB
low complexity region 879 898 N/A INTRINSIC
SAM 914 980 1.6e-11 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930546C10Rik T C 18: 69,080,418 (GRCm39) probably null Het
A2m A G 6: 121,653,906 (GRCm39) N1413S possibly damaging Het
Aadacl4fm4 C T 4: 144,401,188 (GRCm39) V99M probably damaging Het
Arhgap45 A T 10: 79,862,376 (GRCm39) N488Y probably benign Het
Arid4a G A 12: 71,083,889 (GRCm39) D94N probably damaging Het
Atp7a A G X: 105,153,436 (GRCm39) K1114E probably damaging Het
Atp8a2 C T 14: 60,265,512 (GRCm39) V275M probably benign Het
Ceacam12 T C 7: 17,801,357 (GRCm39) V112A probably damaging Het
Cep295 T A 9: 15,229,345 (GRCm39) D2256V probably benign Het
Chid1 A T 7: 141,093,807 (GRCm39) probably null Het
Clcn5 A T X: 7,036,678 (GRCm39) L268* probably null Het
Cldn17 A G 16: 88,303,591 (GRCm39) I46T possibly damaging Het
Cnot1 A T 8: 96,455,346 (GRCm39) I2025N probably damaging Het
Cntn5 C T 9: 9,706,092 (GRCm39) V574M probably damaging Het
Col14a1 T A 15: 55,318,619 (GRCm39) C1373S unknown Het
Col9a1 A G 1: 24,224,205 (GRCm39) N129S unknown Het
Cp C T 3: 20,031,356 (GRCm39) P598S possibly damaging Het
Cpb1 G A 3: 20,320,410 (GRCm39) R150C probably damaging Het
Cyp2j7 T A 4: 96,115,917 (GRCm39) probably null Het
Dnajb7 T C 15: 81,291,692 (GRCm39) E215G possibly damaging Het
Dock1 G A 7: 134,760,239 (GRCm39) R1634Q possibly damaging Het
Dop1b A G 16: 93,554,004 (GRCm39) T313A possibly damaging Het
Fgd2 T A 17: 29,585,971 (GRCm39) V185E probably damaging Het
Flnb T C 14: 7,902,003 (GRCm38) probably null Het
Fzd7 A G 1: 59,523,062 (GRCm39) E315G probably benign Het
Gjd3 T A 11: 102,691,552 (GRCm39) K150N probably benign Het
Gpihbp1 C T 15: 75,469,977 (GRCm39) probably benign Het
Grsf1 G A 5: 88,820,608 (GRCm39) R58* probably null Het
Ifit1 T A 19: 34,625,854 (GRCm39) M330K probably benign Het
Igkv1-122 T C 6: 67,994,178 (GRCm39) V22A probably benign Het
Ikbke A T 1: 131,183,048 (GRCm39) D692E probably benign Het
Il15ra T C 2: 11,737,956 (GRCm39) probably benign Het
Il18rap A G 1: 40,576,244 (GRCm39) I252V probably damaging Het
Klra10 C T 6: 130,249,680 (GRCm39) G202R probably damaging Het
Kpna7 A G 5: 144,929,661 (GRCm39) V388A probably damaging Het
L2hgdh A G 12: 69,768,175 (GRCm39) S108P probably damaging Het
Msto1 G A 3: 88,818,050 (GRCm39) T388M probably benign Het
Naip1 T C 13: 100,562,441 (GRCm39) E908G probably damaging Het
Neto1 C A 18: 86,491,814 (GRCm39) D238E possibly damaging Het
Nlrp5 T A 7: 23,117,159 (GRCm39) D294E probably benign Het
Nr3c2 T C 8: 77,635,816 (GRCm39) S306P probably damaging Het
Or8b41 T A 9: 38,055,167 (GRCm39) C240* probably null Het
Pard3 T A 8: 128,050,544 (GRCm39) L202H probably damaging Het
Pdzd2 T C 15: 12,458,293 (GRCm39) N190S probably damaging Het
Pi4ka T C 16: 17,127,222 (GRCm39) D1077G probably benign Het
Pmfbp1 A C 8: 110,240,543 (GRCm39) L208F probably damaging Het
Pms1 C T 1: 53,246,130 (GRCm39) D470N probably benign Het
Prdm10 T C 9: 31,238,578 (GRCm39) F108L probably benign Het
Rab11fip1 A T 8: 27,644,804 (GRCm39) M327K possibly damaging Het
Slc37a4 T A 9: 44,311,261 (GRCm39) L184Q probably damaging Het
Smdt1 T C 15: 82,232,094 (GRCm39) probably benign Het
Smg6 A G 11: 75,047,117 (GRCm39) Y1270C probably damaging Het
Speer4f2 T A 5: 17,581,565 (GRCm39) V169E possibly damaging Het
Stpg2 C T 3: 139,023,214 (GRCm39) A410V probably benign Het
Tnrc6b T A 15: 80,764,164 (GRCm39) D555E probably benign Het
Tsg101 A G 7: 46,558,808 (GRCm39) Y46H probably damaging Het
Vmn2r111 G A 17: 22,767,553 (GRCm39) S648L probably benign Het
Vmn2r73 T A 7: 85,507,267 (GRCm39) R682* probably null Het
Xkr5 A T 8: 18,983,514 (GRCm39) I676N probably damaging Het
Other mutations in Gpr160
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00768:Gpr160 APN 3 30,950,098 (GRCm39) missense probably damaging 1.00
IGL02952:Gpr160 APN 3 30,950,443 (GRCm39) missense probably benign 0.00
R2259:Gpr160 UTSW 3 30,950,444 (GRCm39) missense probably damaging 0.99
R2416:Gpr160 UTSW 3 30,950,158 (GRCm39) missense probably benign 0.00
R4191:Gpr160 UTSW 3 30,950,863 (GRCm39) missense possibly damaging 0.65
R4688:Gpr160 UTSW 3 30,950,835 (GRCm39) missense probably benign 0.28
R5987:Gpr160 UTSW 3 30,950,612 (GRCm39) missense probably benign
R6209:Gpr160 UTSW 3 30,950,141 (GRCm39) missense possibly damaging 0.56
R6353:Gpr160 UTSW 3 30,950,171 (GRCm39) missense probably damaging 1.00
R7075:Gpr160 UTSW 3 30,950,926 (GRCm39) missense possibly damaging 0.52
R8261:Gpr160 UTSW 3 30,950,096 (GRCm39) missense probably benign 0.08
R8381:Gpr160 UTSW 3 30,949,930 (GRCm39) start codon destroyed probably null 0.99
R8785:Gpr160 UTSW 3 30,950,923 (GRCm39) missense probably damaging 1.00
R9273:Gpr160 UTSW 3 30,950,038 (GRCm39) missense probably benign 0.45
R9487:Gpr160 UTSW 3 30,950,914 (GRCm39) missense probably benign 0.44
R9728:Gpr160 UTSW 3 30,950,144 (GRCm39) missense probably damaging 0.96
Posted On 2013-12-03