Incidental Mutation 'IGL01505:Gpr160'
ID89017
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr160
Ensembl Gene ENSMUSG00000037661
Gene NameG protein-coupled receptor 160
Synonyms1700025D19Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01505
Quality Score
Status
Chromosome3
Chromosomal Location30855950-30897192 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 30895853 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 25 (S25P)
Ref Sequence ENSEMBL: ENSMUSP00000128666 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046624] [ENSMUST00000046748] [ENSMUST00000108258] [ENSMUST00000108259] [ENSMUST00000108261] [ENSMUST00000147697] [ENSMUST00000166278] [ENSMUST00000168645] [ENSMUST00000194979]
Predicted Effect probably benign
Transcript: ENSMUST00000046624
SMART Domains Protein: ENSMUSP00000037862
Gene: ENSMUSG00000037652

DomainStartEndE-ValueType
low complexity region 18 40 N/A INTRINSIC
low complexity region 72 89 N/A INTRINSIC
low complexity region 92 142 N/A INTRINSIC
low complexity region 152 166 N/A INTRINSIC
low complexity region 206 224 N/A INTRINSIC
low complexity region 333 359 N/A INTRINSIC
low complexity region 393 419 N/A INTRINSIC
low complexity region 512 538 N/A INTRINSIC
low complexity region 564 578 N/A INTRINSIC
low complexity region 583 594 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000046748
AA Change: S25P

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000045165
Gene: ENSMUSG00000037661
AA Change: S25P

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000108258
AA Change: S25P

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000103893
Gene: ENSMUSG00000037661
AA Change: S25P

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000108259
AA Change: S25P

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000103894
Gene: ENSMUSG00000037661
AA Change: S25P

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000108261
AA Change: S25P

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000103896
Gene: ENSMUSG00000037661
AA Change: S25P

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000147697
Predicted Effect possibly damaging
Transcript: ENSMUST00000166278
AA Change: S25P

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000128666
Gene: ENSMUSG00000037661
AA Change: S25P

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000168645
SMART Domains Protein: ENSMUSP00000130142
Gene: ENSMUSG00000037652

DomainStartEndE-ValueType
low complexity region 6 28 N/A INTRINSIC
low complexity region 60 77 N/A INTRINSIC
low complexity region 80 130 N/A INTRINSIC
low complexity region 140 154 N/A INTRINSIC
low complexity region 194 212 N/A INTRINSIC
low complexity region 321 347 N/A INTRINSIC
low complexity region 381 407 N/A INTRINSIC
low complexity region 500 526 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
low complexity region 571 601 N/A INTRINSIC
low complexity region 640 648 N/A INTRINSIC
low complexity region 658 686 N/A INTRINSIC
PDB:2L8E|A 775 811 7e-9 PDB
low complexity region 879 898 N/A INTRINSIC
SAM 914 980 1.6e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000194979
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930546C10Rik T C 18: 68,947,347 probably null Het
A2m A G 6: 121,676,947 N1413S possibly damaging Het
Arhgap45 A T 10: 80,026,542 N488Y probably benign Het
Arid4a G A 12: 71,037,115 D94N probably damaging Het
Atp7a A G X: 106,109,830 K1114E probably damaging Het
Atp8a2 C T 14: 60,028,063 V275M probably benign Het
Ceacam12 T C 7: 18,067,432 V112A probably damaging Het
Cep295 T A 9: 15,318,049 D2256V probably benign Het
Chid1 A T 7: 141,513,894 probably null Het
Clcn5 A T X: 7,170,439 L268* probably null Het
Cldn17 A G 16: 88,506,703 I46T possibly damaging Het
Cnot1 A T 8: 95,728,718 I2025N probably damaging Het
Cntn5 C T 9: 9,706,087 V574M probably damaging Het
Col14a1 T A 15: 55,455,223 C1373S unknown Het
Col9a1 A G 1: 24,185,124 N129S unknown Het
Cp C T 3: 19,977,192 P598S possibly damaging Het
Cpb1 G A 3: 20,266,246 R150C probably damaging Het
Cyp2j7 T A 4: 96,227,680 probably null Het
Dnajb7 T C 15: 81,407,491 E215G possibly damaging Het
Dock1 G A 7: 135,158,510 R1634Q possibly damaging Het
Dopey2 A G 16: 93,757,116 T313A possibly damaging Het
Fgd2 T A 17: 29,366,997 V185E probably damaging Het
Flnb T C 14: 7,902,003 probably null Het
Fzd7 A G 1: 59,483,903 E315G probably benign Het
Gjc1 T A 11: 102,800,726 K150N probably benign Het
Gm436 C T 4: 144,674,618 V99M probably damaging Het
Gpihbp1 C T 15: 75,598,128 probably benign Het
Grsf1 G A 5: 88,672,749 R58* probably null Het
Ifit1 T A 19: 34,648,454 M330K probably benign Het
Igkv1-122 T C 6: 68,017,194 V22A probably benign Het
Ikbke A T 1: 131,255,311 D692E probably benign Het
Il15ra T C 2: 11,733,145 probably benign Het
Il18rap A G 1: 40,537,084 I252V probably damaging Het
Klra10 C T 6: 130,272,717 G202R probably damaging Het
Kpna7 A G 5: 144,992,851 V388A probably damaging Het
L2hgdh A G 12: 69,721,401 S108P probably damaging Het
Msto1 G A 3: 88,910,743 T388M probably benign Het
Naip1 T C 13: 100,425,933 E908G probably damaging Het
Neto1 C A 18: 86,473,689 D238E possibly damaging Het
Nlrp5 T A 7: 23,417,734 D294E probably benign Het
Nr3c2 T C 8: 76,909,187 S306P probably damaging Het
Olfr890 T A 9: 38,143,871 C240* probably null Het
Pard3 T A 8: 127,324,063 L202H probably damaging Het
Pdzd2 T C 15: 12,458,207 N190S probably damaging Het
Pi4ka T C 16: 17,309,358 D1077G probably benign Het
Pmfbp1 A C 8: 109,513,911 L208F probably damaging Het
Pms1 C T 1: 53,206,971 D470N probably benign Het
Prdm10 T C 9: 31,327,282 F108L probably benign Het
Rab11fip1 A T 8: 27,154,776 M327K possibly damaging Het
Slc37a4 T A 9: 44,399,964 L184Q probably damaging Het
Smdt1 T C 15: 82,347,893 probably benign Het
Smg6 A G 11: 75,156,291 Y1270C probably damaging Het
Speer4f2 T A 5: 17,376,567 V169E possibly damaging Het
Stpg2 C T 3: 139,317,453 A410V probably benign Het
Tnrc6b T A 15: 80,879,963 D555E probably benign Het
Tsg101 A G 7: 46,909,060 Y46H probably damaging Het
Vmn2r111 G A 17: 22,548,572 S648L probably benign Het
Vmn2r73 T A 7: 85,858,059 R682* probably null Het
Xkr5 A T 8: 18,933,498 I676N probably damaging Het
Other mutations in Gpr160
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00768:Gpr160 APN 3 30895949 missense probably damaging 1.00
IGL02952:Gpr160 APN 3 30896294 missense probably benign 0.00
R2259:Gpr160 UTSW 3 30896295 missense probably damaging 0.99
R2416:Gpr160 UTSW 3 30896009 missense probably benign 0.00
R4191:Gpr160 UTSW 3 30896714 missense possibly damaging 0.65
R4688:Gpr160 UTSW 3 30896686 missense probably benign 0.28
R5987:Gpr160 UTSW 3 30896463 missense probably benign
R6209:Gpr160 UTSW 3 30895992 missense possibly damaging 0.56
R6353:Gpr160 UTSW 3 30896022 missense probably damaging 1.00
R7075:Gpr160 UTSW 3 30896777 missense possibly damaging 0.52
R8261:Gpr160 UTSW 3 30895947 missense probably benign 0.08
R8381:Gpr160 UTSW 3 30895781 start codon destroyed probably null 0.99
Posted On2013-12-03