Incidental Mutation 'IGL01509:Zfp759'
| ID |
89152 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp759
|
| Ensembl Gene |
ENSMUSG00000057396 |
| Gene Name |
zinc finger protein 759 |
| Synonyms |
Rslcan-8 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
IGL01509
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
67273040-67290468 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 67287658 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 403
(N403S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000049650
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000052716]
[ENSMUST00000224346]
|
| AlphaFold |
Q7M6X3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000052716
AA Change: N403S
PolyPhen 2
Score 0.249 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000049650
Gene: ENSMUSG00000057396
AA Change: N403S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
65 |
1.6e-22 |
SMART |
|
ZnF_C2H2
|
106 |
128 |
5.54e1 |
SMART |
|
ZnF_C2H2
|
162 |
184 |
3.83e-2 |
SMART |
|
ZnF_C2H2
|
190 |
212 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
218 |
240 |
1.64e-1 |
SMART |
|
ZnF_C2H2
|
246 |
268 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
274 |
296 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
302 |
324 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
330 |
352 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
358 |
380 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
386 |
408 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
414 |
436 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
498 |
520 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
526 |
548 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
554 |
576 |
2.02e-1 |
SMART |
|
ZnF_C2H2
|
582 |
604 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
610 |
632 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
638 |
660 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
666 |
688 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
694 |
716 |
4.17e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223605
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224346
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224426
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 22 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A4gnt |
T |
A |
9: 99,495,819 (GRCm39) |
I85N |
probably benign |
Het |
| Bbof1 |
T |
A |
12: 84,457,859 (GRCm39) |
N41K |
possibly damaging |
Het |
| Cdh10 |
A |
G |
15: 18,986,884 (GRCm39) |
K372E |
possibly damaging |
Het |
| Clmn |
T |
A |
12: 104,747,162 (GRCm39) |
Q795L |
probably benign |
Het |
| Dnai4 |
G |
A |
4: 102,929,884 (GRCm39) |
P369L |
possibly damaging |
Het |
| Enox1 |
T |
C |
14: 77,936,713 (GRCm39) |
S583P |
probably damaging |
Het |
| Hmcn1 |
C |
T |
1: 150,485,382 (GRCm39) |
G4407S |
probably damaging |
Het |
| Ifi206 |
T |
A |
1: 173,313,142 (GRCm39) |
M109L |
probably benign |
Het |
| Ighmbp2 |
A |
G |
19: 3,318,711 (GRCm39) |
M455T |
possibly damaging |
Het |
| Inpp4b |
T |
C |
8: 82,617,332 (GRCm39) |
|
probably benign |
Het |
| Mctp2 |
A |
G |
7: 71,909,017 (GRCm39) |
S99P |
probably benign |
Het |
| Mrgprb2 |
G |
A |
7: 48,202,674 (GRCm39) |
T17M |
possibly damaging |
Het |
| Ogdhl |
T |
A |
14: 32,059,716 (GRCm39) |
M410K |
probably damaging |
Het |
| Pard3b |
A |
T |
1: 62,200,407 (GRCm39) |
R315S |
possibly damaging |
Het |
| Pde3b |
A |
G |
7: 114,117,645 (GRCm39) |
Q625R |
probably benign |
Het |
| Plxna3 |
A |
G |
X: 73,376,039 (GRCm39) |
Q355R |
probably benign |
Het |
| Ptprm |
A |
T |
17: 67,069,208 (GRCm39) |
F907I |
possibly damaging |
Het |
| Slc16a4 |
A |
C |
3: 107,218,750 (GRCm39) |
|
probably null |
Het |
| Tasor |
T |
C |
14: 27,181,731 (GRCm39) |
|
probably benign |
Het |
| Vmn1r82 |
A |
T |
7: 12,039,096 (GRCm39) |
H123L |
probably damaging |
Het |
| Vmn2r1 |
T |
C |
3: 64,010,466 (GRCm39) |
I568T |
probably benign |
Het |
| Zfp7 |
G |
A |
15: 76,765,333 (GRCm39) |
V9M |
probably damaging |
Het |
|
| Other mutations in Zfp759 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03131:Zfp759
|
APN |
13 |
67,286,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03218:Zfp759
|
APN |
13 |
67,287,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0243:Zfp759
|
UTSW |
13 |
67,286,877 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0319:Zfp759
|
UTSW |
13 |
67,288,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0520:Zfp759
|
UTSW |
13 |
67,285,419 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0961:Zfp759
|
UTSW |
13 |
67,287,927 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1435:Zfp759
|
UTSW |
13 |
67,286,830 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1649:Zfp759
|
UTSW |
13 |
67,287,668 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1880:Zfp759
|
UTSW |
13 |
67,287,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2118:Zfp759
|
UTSW |
13 |
67,287,578 (GRCm39) |
unclassified |
probably benign |
|
|
R2170:Zfp759
|
UTSW |
13 |
67,284,812 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3154:Zfp759
|
UTSW |
13 |
67,286,719 (GRCm39) |
missense |
probably benign |
0.20 |
|
R3551:Zfp759
|
UTSW |
13 |
67,287,031 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4392:Zfp759
|
UTSW |
13 |
67,287,707 (GRCm39) |
nonsense |
probably null |
|
|
R4495:Zfp759
|
UTSW |
13 |
67,286,989 (GRCm39) |
splice site |
probably null |
|
|
R4736:Zfp759
|
UTSW |
13 |
67,287,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4882:Zfp759
|
UTSW |
13 |
67,287,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5717:Zfp759
|
UTSW |
13 |
67,286,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5921:Zfp759
|
UTSW |
13 |
67,288,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Zfp759
|
UTSW |
13 |
67,288,524 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6381:Zfp759
|
UTSW |
13 |
67,286,969 (GRCm39) |
nonsense |
probably null |
|
|
R6427:Zfp759
|
UTSW |
13 |
67,287,162 (GRCm39) |
splice site |
probably null |
|
|
R6567:Zfp759
|
UTSW |
13 |
67,287,150 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7140:Zfp759
|
UTSW |
13 |
67,288,177 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7731:Zfp759
|
UTSW |
13 |
67,287,690 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8504:Zfp759
|
UTSW |
13 |
67,286,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8770:Zfp759
|
UTSW |
13 |
67,288,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9250:Zfp759
|
UTSW |
13 |
67,288,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9695:Zfp759
|
UTSW |
13 |
67,287,198 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1176:Zfp759
|
UTSW |
13 |
67,284,872 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Zfp759
|
UTSW |
13 |
67,288,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-12-03 |
Incidental Mutation