Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01510:Lrig3'

89166

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrig3

Ensembl Gene

ENSMUSG00000020105

Gene Name

leucine-rich repeats and immunoglobulin-like domains 3

Synonyms

9030421L11Rik, 9430095K15Rik, 9130004I02Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.233) question?

Stock #

IGL01510

Quality Score

Status

Chromosome

Chromosomal Location

125966168-126015359 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 126008698 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 677 (T677K)

Ref Sequence

ENSEMBL: ENSMUSP00000074360 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074807]

AlphaFold

Q6P1C6

PDB Structure

Crystal structure of an Immunoglobulin I-set domain of Lrig3 protein (Lrig3) from MUS MUSCULUS at 1.70 A resolution [X-RAY DIFFRACTION]

Predicted Effect

probably damaging
Transcript: ENSMUST00000074807
AA Change: T677K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000074360
Gene: ENSMUSG00000020105
AA Change: T677K

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
LRRNT	46	78	6.74e-2	SMART
LRR	72	96	4.45e1	SMART
LRR	97	120	1.06e1	SMART
LRR	144	166	1.14e0	SMART
LRR	168	189	1.62e2	SMART
LRR	190	214	1.09e1	SMART
LRR	215	237	1.71e1	SMART
LRR	238	261	2.29e0	SMART
LRR	262	285	3.07e-1	SMART
LRR	286	309	2.49e-1	SMART
LRR	310	333	1.29e1	SMART
LRR	334	357	6.22e0	SMART
LRR	358	384	6.05e0	SMART
LRR_TYP	385	408	1.56e-2	SMART
LRR_TYP	409	432	1.79e-2	SMART
LRRCT	444	494	2.35e-7	SMART
IGc2	511	588	1.65e-4	SMART
IGc2	615	683	1.33e-8	SMART
IGc2	709	774	2.78e-11	SMART
transmembrane domain	805	827	N/A	INTRINSIC
low complexity region	1069	1081	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218580

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219974

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220332

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele or severely hypomorphic gene trap allele exhibit fusion of the lateral semicircular canal and circling behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca1	T	C	4: 53,143,979 (GRCm38)	Q6R	probably damaging	Het
Adam5	A	T	8: 24,804,465 (GRCm38)	C373S	probably damaging	Het
Adgre4	T	C	17: 55,818,760 (GRCm38)		probably null	Het
Akap10	A	T	11: 61,878,020 (GRCm38)	M614K	possibly damaging	Het
Amigo2	T	C	15: 97,245,081 (GRCm38)	T487A	probably benign	Het
Asap1	T	C	15: 64,158,928 (GRCm38)	D300G	probably damaging	Het
Atp4a	C	A	7: 30,720,791 (GRCm38)	L788M	probably benign	Het
Bcl3	T	A	7: 19,809,614 (GRCm38)	H309L	probably damaging	Het
Cblc	T	C	7: 19,785,275 (GRCm38)	N376S	probably benign	Het
Cd200r2	A	T	16: 44,909,311 (GRCm38)	I110L	probably benign	Het
Ceacam3	T	C	7: 17,159,842 (GRCm38)	M426T	probably benign	Het
Cep295	G	A	9: 15,354,626 (GRCm38)	R29*	probably null	Het
Ces1a	G	T	8: 93,045,098 (GRCm38)	P24T	probably damaging	Het
Ctps	G	T	4: 120,558,844 (GRCm38)	T194K	probably damaging	Het
Cul3	A	G	1: 80,282,679 (GRCm38)	S318P	probably damaging	Het
Fasl	A	T	1: 161,781,953 (GRCm38)	S155T	possibly damaging	Het
Gldc	C	T	19: 30,113,721 (GRCm38)		probably null	Het
Gpr21	T	A	2: 37,518,421 (GRCm38)	C326*	probably null	Het
Gtf2a1	A	G	12: 91,567,833 (GRCm38)	S216P	probably benign	Het
Hoxb5	A	T	11: 96,303,992 (GRCm38)	S127C	possibly damaging	Het
Htt	A	T	5: 34,907,512 (GRCm38)	Q3023L	probably damaging	Het
Kalrn	T	A	16: 34,235,330 (GRCm38)	H855L	possibly damaging	Het
Lars	T	C	18: 42,242,109 (GRCm38)	I289V	probably benign	Het
Mapk7	A	T	11: 61,491,160 (GRCm38)	W309R	probably damaging	Het
Mmp12	A	G	9: 7,358,307 (GRCm38)	T468A	possibly damaging	Het
Muc5b	A	T	7: 141,859,061 (GRCm38)	N1915Y	unknown	Het
Naprt	A	G	15: 75,890,988 (GRCm38)		probably benign	Het
Nfatc1	T	C	18: 80,698,188 (GRCm38)	Y199C	probably damaging	Het
Olfr857	A	T	9: 19,713,279 (GRCm38)	I151F	probably benign	Het
Olfr919	T	C	9: 38,697,905 (GRCm38)	I158V	probably benign	Het
Phip	T	A	9: 82,913,871 (GRCm38)	I566F	probably benign	Het
Pnpla3	T	A	15: 84,171,072 (GRCm38)		probably benign	Het
Ptpn13	C	T	5: 103,562,300 (GRCm38)	T1567I	probably damaging	Het
Ptpn20	A	G	14: 33,638,386 (GRCm38)		probably null	Het
Ptprq	G	T	10: 107,712,048 (GRCm38)	T163K	probably damaging	Het
Slc8a1	A	G	17: 81,648,365 (GRCm38)	C415R	probably damaging	Het
Slco4c1	A	G	1: 96,867,953 (GRCm38)	S127P	probably damaging	Het
Tcerg1l	A	T	7: 138,394,305 (GRCm38)		probably benign	Het
Thbd	C	T	2: 148,406,974 (GRCm38)	V325M	probably damaging	Het
Trim37	G	A	11: 87,177,860 (GRCm38)	R344H	probably damaging	Het
Ttn	T	C	2: 76,872,765 (GRCm38)		probably benign	Het
Uvrag	G	A	7: 99,004,589 (GRCm38)	Q65*	probably null	Het
Wrap53	G	A	11: 69,562,740 (GRCm38)	S342L	possibly damaging	Het
Zbtb11	T	G	16: 55,990,343 (GRCm38)	V288G	probably damaging	Het

Other mutations in Lrig3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Lrig3	APN	10	126,013,148 (GRCm38)	missense	probably benign	0.00
IGL00426:Lrig3	APN	10	125,972,137 (GRCm38)	nonsense	probably null
IGL00969:Lrig3	APN	10	125,997,115 (GRCm38)	missense	probably damaging	1.00
IGL01376:Lrig3	APN	10	125,994,466 (GRCm38)	missense	probably benign	0.01
IGL01825:Lrig3	APN	10	126,010,017 (GRCm38)	missense	probably damaging	0.98
IGL02231:Lrig3	APN	10	125,997,172 (GRCm38)	missense	probably damaging	1.00
IGL02377:Lrig3	APN	10	126,014,874 (GRCm38)	missense	probably benign	0.00
IGL02648:Lrig3	APN	10	125,966,594 (GRCm38)	missense	probably benign
IGL02832:Lrig3	APN	10	126,007,002 (GRCm38)	missense	probably benign	0.37
IGL03266:Lrig3	APN	10	126,013,282 (GRCm38)	missense	probably benign	0.28
R0023:Lrig3	UTSW	10	126,010,219 (GRCm38)	missense	probably damaging	1.00
R0129:Lrig3	UTSW	10	126,006,943 (GRCm38)	missense	probably damaging	1.00
R0183:Lrig3	UTSW	10	126,010,192 (GRCm38)	missense	probably damaging	1.00
R0226:Lrig3	UTSW	10	125,972,117 (GRCm38)	splice site	probably benign
R0233:Lrig3	UTSW	10	126,013,526 (GRCm38)	splice site	probably null
R0233:Lrig3	UTSW	10	126,013,526 (GRCm38)	splice site	probably null
R0336:Lrig3	UTSW	10	125,966,705 (GRCm38)	missense	probably benign	0.04
R0348:Lrig3	UTSW	10	126,013,448 (GRCm38)	nonsense	probably null
R0502:Lrig3	UTSW	10	126,008,736 (GRCm38)	missense	probably damaging	1.00
R0639:Lrig3	UTSW	10	126,010,221 (GRCm38)	missense	probably damaging	1.00
R1099:Lrig3	UTSW	10	126,007,014 (GRCm38)	splice site	probably null
R1220:Lrig3	UTSW	10	125,997,076 (GRCm38)	missense	probably damaging	1.00
R1230:Lrig3	UTSW	10	126,002,971 (GRCm38)	missense	probably damaging	1.00
R1398:Lrig3	UTSW	10	126,003,088 (GRCm38)	missense	probably benign	0.00
R1451:Lrig3	UTSW	10	126,010,057 (GRCm38)	missense	possibly damaging	0.92
R1523:Lrig3	UTSW	10	126,008,698 (GRCm38)	missense	probably damaging	1.00
R1545:Lrig3	UTSW	10	126,008,547 (GRCm38)	missense	possibly damaging	0.80
R1661:Lrig3	UTSW	10	125,997,701 (GRCm38)	missense	probably benign	0.12
R1665:Lrig3	UTSW	10	125,997,701 (GRCm38)	missense	probably benign	0.12
R1673:Lrig3	UTSW	10	126,010,167 (GRCm38)	missense	probably damaging	1.00
R1778:Lrig3	UTSW	10	126,010,075 (GRCm38)	missense	probably damaging	1.00
R1800:Lrig3	UTSW	10	125,997,051 (GRCm38)	splice site	probably null
R1840:Lrig3	UTSW	10	126,013,389 (GRCm38)	nonsense	probably null
R1882:Lrig3	UTSW	10	126,009,825 (GRCm38)	missense	possibly damaging	0.89
R1900:Lrig3	UTSW	10	126,002,393 (GRCm38)	splice site	probably benign
R2160:Lrig3	UTSW	10	125,997,696 (GRCm38)	missense	possibly damaging	0.95
R2200:Lrig3	UTSW	10	125,996,609 (GRCm38)	splice site	probably null
R2294:Lrig3	UTSW	10	125,966,494 (GRCm38)	nonsense	probably null
R2518:Lrig3	UTSW	10	125,994,441 (GRCm38)	missense	probably benign	0.07
R3037:Lrig3	UTSW	10	126,010,032 (GRCm38)	missense	probably damaging	1.00
R3236:Lrig3	UTSW	10	125,997,187 (GRCm38)	missense	probably damaging	1.00
R4073:Lrig3	UTSW	10	126,013,408 (GRCm38)	missense	probably benign
R4074:Lrig3	UTSW	10	126,013,408 (GRCm38)	missense	probably benign
R4075:Lrig3	UTSW	10	126,013,408 (GRCm38)	missense	probably benign
R4077:Lrig3	UTSW	10	126,009,787 (GRCm38)	missense	probably damaging	1.00
R4079:Lrig3	UTSW	10	126,009,787 (GRCm38)	missense	probably damaging	1.00
R4405:Lrig3	UTSW	10	126,011,008 (GRCm38)	missense	probably benign	0.00
R4425:Lrig3	UTSW	10	126,013,404 (GRCm38)	missense	probably benign	0.00
R4505:Lrig3	UTSW	10	126,013,347 (GRCm38)	missense	probably benign	0.00
R4860:Lrig3	UTSW	10	126,011,052 (GRCm38)	missense	probably benign	0.36
R4860:Lrig3	UTSW	10	126,011,052 (GRCm38)	missense	probably benign	0.36
R4903:Lrig3	UTSW	10	125,996,613 (GRCm38)	critical splice acceptor site	probably null
R5201:Lrig3	UTSW	10	126,013,151 (GRCm38)	missense	possibly damaging	0.48
R5307:Lrig3	UTSW	10	126,006,690 (GRCm38)	missense	probably damaging	1.00
R5402:Lrig3	UTSW	10	126,008,740 (GRCm38)	missense	probably damaging	1.00
R5557:Lrig3	UTSW	10	125,972,134 (GRCm38)	missense	probably damaging	1.00
R5792:Lrig3	UTSW	10	126,009,919 (GRCm38)	missense	probably damaging	1.00
R5903:Lrig3	UTSW	10	126,008,478 (GRCm38)	missense	probably damaging	1.00
R6280:Lrig3	UTSW	10	126,010,979 (GRCm38)	missense	probably benign	0.18
R6484:Lrig3	UTSW	10	125,996,609 (GRCm38)	splice site	probably null
R6985:Lrig3	UTSW	10	126,014,869 (GRCm38)	missense	possibly damaging	0.64
R7089:Lrig3	UTSW	10	125,997,124 (GRCm38)	missense	probably damaging	1.00
R7177:Lrig3	UTSW	10	126,006,843 (GRCm38)	missense	probably benign	0.02
R7347:Lrig3	UTSW	10	126,009,966 (GRCm38)	missense	probably damaging	1.00
R9093:Lrig3	UTSW	10	126,010,081 (GRCm38)	missense	possibly damaging	0.51
R9188:Lrig3	UTSW	10	126,003,066 (GRCm38)	missense	possibly damaging	0.80
R9295:Lrig3	UTSW	10	126,014,853 (GRCm38)	missense	probably benign	0.00
R9378:Lrig3	UTSW	10	125,997,084 (GRCm38)	missense	probably damaging	0.98
R9526:Lrig3	UTSW	10	126,014,867 (GRCm38)	missense	probably benign
R9567:Lrig3	UTSW	10	126,010,095 (GRCm38)	missense	probably benign	0.00

Posted On

2013-12-03