Incidental Mutation 'IGL01518:Scrt2'
ID89384
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Scrt2
Ensembl Gene ENSMUSG00000060257
Gene Namescratch family zinc finger 2
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.144) question?
Stock #IGL01518
Quality Score
Status
Chromosome2
Chromosomal Location152081529-152095802 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 152093640 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Serine at position 238 (R238S)
Ref Sequence ENSEMBL: ENSMUSP00000066280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064061]
Predicted Effect probably damaging
Transcript: ENSMUST00000064061
AA Change: R238S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000066280
Gene: ENSMUSG00000060257
AA Change: R238S

DomainStartEndE-ValueType
low complexity region 64 82 N/A INTRINSIC
low complexity region 114 158 N/A INTRINSIC
ZnF_C2H2 161 183 1.26e-2 SMART
ZnF_C2H2 192 214 6.23e-2 SMART
ZnF_C2H2 218 240 6.42e-4 SMART
ZnF_C2H2 246 268 7.9e-4 SMART
ZnF_C2H2 274 294 5.26e1 SMART
low complexity region 300 311 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447F04Rik A C X: 66,304,054 V16G unknown Het
4933427I04Rik A T 4: 123,860,701 E136V probably benign Het
Aadac A G 3: 60,035,899 D75G probably damaging Het
Arfgap1 T A 2: 180,972,725 S125T probably benign Het
Atxn2 G T 5: 121,810,979 A813S probably damaging Het
Cadps C A 14: 12,522,352 S604I probably damaging Het
Ces1a G T 8: 93,045,098 P24T probably damaging Het
Col4a4 T A 1: 82,455,759 M1488L unknown Het
Fndc3c1 T C X: 106,431,423 N941S probably damaging Het
Fryl T C 5: 73,086,962 Y1172C possibly damaging Het
Gm1527 T C 3: 28,895,588 probably benign Het
Hsf2 T C 10: 57,512,134 L458P probably damaging Het
Il2 T C 3: 37,123,007 T127A possibly damaging Het
Inpp5e A G 2: 26,397,934 Y617H probably damaging Het
Isoc2b G A 7: 4,850,764 S137F probably damaging Het
Map2 C T 1: 66,425,331 P241S probably damaging Het
Mfsd6 C A 1: 52,709,322 R128L probably damaging Het
Mrnip A G 11: 50,197,635 T153A probably damaging Het
Olfr1269 A G 2: 90,118,971 F209S possibly damaging Het
Olfr26 A T 9: 38,855,799 M246L probably benign Het
Pi4ka T C 16: 17,280,735 N2022S probably benign Het
St3gal6 T A 16: 58,484,775 D108V probably benign Het
Tmem132b C T 5: 125,778,791 T529M probably damaging Het
Trappc11 T C 8: 47,501,869 probably null Het
Tspyl1 T A 10: 34,283,199 S307T possibly damaging Het
Ush2a A G 1: 188,399,785 S735G probably benign Het
Wnk2 T C 13: 49,068,192 M1186V possibly damaging Het
Other mutations in Scrt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1747:Scrt2 UTSW 2 152093718 missense probably damaging 1.00
R1989:Scrt2 UTSW 2 152082087 missense probably damaging 0.96
R5443:Scrt2 UTSW 2 152082123 missense probably benign 0.22
R6543:Scrt2 UTSW 2 152093143 missense probably benign
R7126:Scrt2 UTSW 2 152093086 missense probably damaging 1.00
Posted On2013-12-03