Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01518:Scrt2'

89384

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scrt2

Ensembl Gene

ENSMUSG00000060257

Gene Name

scratch family zinc finger 2

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.114) question?

Stock #

IGL01518

Quality Score

Status

Chromosome

Chromosomal Location

151923737-151937722 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 151935560 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 238 (R238S)

Ref Sequence

ENSEMBL: ENSMUSP00000066280 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064061]

AlphaFold

Q8BTH6

Predicted Effect

probably damaging
Transcript: ENSMUST00000064061
AA Change: R238S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000066280
Gene: ENSMUSG00000060257
AA Change: R238S

Domain	Start	End	E-Value	Type
low complexity region	64	82	N/A	INTRINSIC
low complexity region	114	158	N/A	INTRINSIC
ZnF_C2H2	161	183	1.26e-2	SMART
ZnF_C2H2	192	214	6.23e-2	SMART
ZnF_C2H2	218	240	6.42e-4	SMART
ZnF_C2H2	246	268	7.9e-4	SMART
ZnF_C2H2	274	294	5.26e1	SMART
low complexity region	300	311	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447F04Rik	A	C	X: 65,347,660 (GRCm39)	V16G	unknown	Het
4933427I04Rik	A	T	4: 123,754,494 (GRCm39)	E136V	probably benign	Het
Aadac	A	G	3: 59,943,320 (GRCm39)	D75G	probably damaging	Het
Arfgap1	T	A	2: 180,614,518 (GRCm39)	S125T	probably benign	Het
Atxn2	G	T	5: 121,949,042 (GRCm39)	A813S	probably damaging	Het
Cadps	C	A	14: 12,522,352 (GRCm38)	S604I	probably damaging	Het
Ces1a	G	T	8: 93,771,726 (GRCm39)	P24T	probably damaging	Het
Col4a4	T	A	1: 82,433,480 (GRCm39)	M1488L	unknown	Het
Fndc3c1	T	C	X: 105,475,029 (GRCm39)	N941S	probably damaging	Het
Fryl	T	C	5: 73,244,305 (GRCm39)	Y1172C	possibly damaging	Het
Gm1527	T	C	3: 28,949,737 (GRCm39)		probably benign	Het
Hsf2	T	C	10: 57,388,230 (GRCm39)	L458P	probably damaging	Het
Il2	T	C	3: 37,177,156 (GRCm39)	T127A	possibly damaging	Het
Inpp5e	A	G	2: 26,287,946 (GRCm39)	Y617H	probably damaging	Het
Isoc2b	G	A	7: 4,853,763 (GRCm39)	S137F	probably damaging	Het
Map2	C	T	1: 66,464,490 (GRCm39)	P241S	probably damaging	Het
Mfsd6	C	A	1: 52,748,481 (GRCm39)	R128L	probably damaging	Het
Mrnip	A	G	11: 50,088,462 (GRCm39)	T153A	probably damaging	Het
Or4x6	A	G	2: 89,949,315 (GRCm39)	F209S	possibly damaging	Het
Or8d1	A	T	9: 38,767,095 (GRCm39)	M246L	probably benign	Het
Pi4ka	T	C	16: 17,098,599 (GRCm39)	N2022S	probably benign	Het
St3gal6	T	A	16: 58,305,138 (GRCm39)	D108V	probably benign	Het
Tmem132b	C	T	5: 125,855,855 (GRCm39)	T529M	probably damaging	Het
Trappc11	T	C	8: 47,954,904 (GRCm39)		probably null	Het
Tspyl1	T	A	10: 34,159,195 (GRCm39)	S307T	possibly damaging	Het
Ush2a	A	G	1: 188,131,982 (GRCm39)	S735G	probably benign	Het
Wnk2	T	C	13: 49,221,668 (GRCm39)	M1186V	possibly damaging	Het

Other mutations in Scrt2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1747:Scrt2	UTSW	2	151,935,638 (GRCm39)	missense	probably damaging	1.00
R1989:Scrt2	UTSW	2	151,924,007 (GRCm39)	missense	probably damaging	0.96
R5443:Scrt2	UTSW	2	151,924,043 (GRCm39)	missense	probably benign	0.22
R6543:Scrt2	UTSW	2	151,935,063 (GRCm39)	missense	probably benign
R7126:Scrt2	UTSW	2	151,935,006 (GRCm39)	missense	probably damaging	1.00
R9680:Scrt2	UTSW	2	151,924,018 (GRCm39)	missense	probably benign	0.03

Posted On

2013-12-03