Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01519:Gm10436'

89390

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm10436

Ensembl Gene

ENSMUSG00000066027

Gene Name

predicted gene 10436

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

IGL01519

Quality Score

Status

Chromosome

Chromosomal Location

88175589-88182108 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 88177561 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 161 (R161G)

Ref Sequence

ENSEMBL: ENSMUSP00000152194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071580] [ENSMUST00000220521] [ENSMUST00000222081] [ENSMUST00000223172]

Predicted Effect

probably benign
Transcript: ENSMUST00000071580
AA Change: R169G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000071508
Gene: ENSMUSG00000066027
AA Change: R169G

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	247	445	5e-9	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000220521

Predicted Effect

probably benign
Transcript: ENSMUST00000221884

Predicted Effect

probably benign
Transcript: ENSMUST00000222081
AA Change: R161G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

probably benign
Transcript: ENSMUST00000222391

Predicted Effect

unknown
Transcript: ENSMUST00000222556
AA Change: R160G

Predicted Effect

probably benign
Transcript: ENSMUST00000223172

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap17b	T	C	X: 36,611,850	D668G	probably damaging	Het
Btbd3	A	G	2: 138,279,777	M127V	probably benign	Het
Btbd9	T	C	17: 30,299,601	T462A	possibly damaging	Het
Ces1a	G	T	8: 93,045,098	P24T	probably damaging	Het
Chd1	G	A	17: 17,378,569	G98R	probably damaging	Het
Ckap2	G	A	8: 22,168,898	R610C	probably benign	Het
Col18a1	C	T	10: 77,059,323	R1168H	probably damaging	Het
Csmd3	G	A	15: 47,596,850	T3515I	probably benign	Het
Dcn	A	G	10: 97,483,523	Q54R	probably damaging	Het
Dock11	A	G	X: 35,963,353	I86V	probably benign	Het
Dram2	T	A	3: 106,571,629	I179N	possibly damaging	Het
Fbn1	C	T	2: 125,317,019	M2275I	probably benign	Het
Gga2	A	G	7: 122,002,188	S231P	probably damaging	Het
Gk2	T	A	5: 97,455,787	L397F	probably damaging	Het
Gm8122	T	A	14: 43,235,239	I22L	unknown	Het
Golga4	A	G	9: 118,527,092	E104G	probably damaging	Het
Herc2	G	A	7: 56,103,950	R699H	probably damaging	Het
Hrh1	A	C	6: 114,480,301	E181A	probably damaging	Het
Lsm8	T	C	6: 18,851,700	F50S	probably damaging	Het
Olfr161	T	A	16: 3,592,534	I46N	probably damaging	Het
Pard6g	A	G	18: 80,079,856	D35G	probably benign	Het
Plod2	G	A	9: 92,595,295	V347I	probably benign	Het
Snx13	T	C	12: 35,138,472		probably benign	Het
Taf1	T	A	X: 101,562,806		probably benign	Het
Tarsl2	A	G	7: 65,663,886	Y351C	probably damaging	Het
Tenm4	C	A	7: 96,895,177	D2133E	probably damaging	Het
Thap7	A	C	16: 17,528,745		probably benign	Het
Tpr	T	A	1: 150,431,168	S1505T	probably benign	Het
Trav9-2	C	T	14: 53,591,352	R60W	probably damaging	Het
Ttn	A	G	2: 76,878,348		probably benign	Het

Other mutations in Gm10436

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00421:Gm10436	APN	12	88177112	missense	probably benign	0.35
IGL01391:Gm10436	APN	12	88178455	missense	possibly damaging	0.84
IGL01432:Gm10436	APN	12	88176432	missense	probably benign	0.44
IGL01784:Gm10436	APN	12	88176315	missense	probably benign
IGL02121:Gm10436	APN	12	88178472	missense	possibly damaging	0.83
IGL02728:Gm10436	APN	12	88176022	missense	probably benign	0.17
R0336:Gm10436	UTSW	12	88178191	missense	probably benign	0.20
R0554:Gm10436	UTSW	12	88177558	missense	probably benign	0.10
R1279:Gm10436	UTSW	12	88175880	missense	probably benign	0.42
R1832:Gm10436	UTSW	12	88178448	missense	possibly damaging	0.73
R1833:Gm10436	UTSW	12	88178448	missense	possibly damaging	0.73
R1900:Gm10436	UTSW	12	88177260	missense	probably benign	0.02
R2412:Gm10436	UTSW	12	88177110	missense	probably damaging	0.98
R3040:Gm10436	UTSW	12	88178348	missense	probably benign	0.00
R3625:Gm10436	UTSW	12	88175961	missense	probably benign	0.06
R4078:Gm10436	UTSW	12	88175913	missense	probably benign	0.38
R4270:Gm10436	UTSW	12	88178283	missense	probably damaging	1.00
R4271:Gm10436	UTSW	12	88178283	missense	probably damaging	1.00
R5318:Gm10436	UTSW	12	88176228	missense	probably benign	0.01
R5552:Gm10436	UTSW	12	88178365	missense	probably benign	0.03
R5601:Gm10436	UTSW	12	88176047	missense	probably damaging	1.00
R5881:Gm10436	UTSW	12	88176341	missense	probably damaging	1.00
R5973:Gm10436	UTSW	12	88175913	missense	probably benign	0.02
R6058:Gm10436	UTSW	12	88177225	missense	possibly damaging	0.91
R6488:Gm10436	UTSW	12	88177587	missense	possibly damaging	0.87
R6656:Gm10436	UTSW	12	88175993	missense	possibly damaging	0.89
R7307:Gm10436	UTSW	12	88181749	missense	probably damaging	1.00
R7332:Gm10436	UTSW	12	88176417	missense	possibly damaging	0.72
R7544:Gm10436	UTSW	12	88176080	missense	probably benign	0.00
R7569:Gm10436	UTSW	12	88176315	missense	probably benign
R7645:Gm10436	UTSW	12	88176258	missense	probably damaging	1.00
R7752:Gm10436	UTSW	12	88175999	missense	probably damaging	1.00
R7855:Gm10436	UTSW	12	88176083	missense	probably benign	0.03
R7860:Gm10436	UTSW	12	88176352	missense	possibly damaging	0.89
R8113:Gm10436	UTSW	12	88177080	missense	probably benign	0.00
R8356:Gm10436	UTSW	12	88177216	missense	probably benign	0.01
R8456:Gm10436	UTSW	12	88177216	missense	probably benign	0.01

Posted On

2013-12-03