Incidental Mutation 'IGL01522:Tas2r119'
ID 89428
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r119
Ensembl Gene ENSMUSG00000045267
Gene Name taste receptor, type 2, member 119
Synonyms mGR19, T2R19, mt2r19, Tas2r19
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01522
Quality Score
Status
Chromosome 15
Chromosomal Location 32177289-32178294 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 32178193 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 302 (V302I)
Ref Sequence ENSEMBL: ENSMUSP00000050277 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057633]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000057633
AA Change: V302I

PolyPhen 2 Score 0.148 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000050277
Gene: ENSMUSG00000045267
AA Change: V302I

DomainStartEndE-ValueType
Pfam:TAS2R 1 293 1.1e-90 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik A G 11: 23,582,865 probably null Het
Adamts12 T C 15: 11,065,159 probably null Het
Adamts3 T C 5: 89,702,943 N579S probably benign Het
Akr1c19 A G 13: 4,239,099 probably benign Het
Ankrd39 T A 1: 36,542,061 H69L probably damaging Het
Apcdd1 T A 18: 62,952,115 M461K possibly damaging Het
Bpifa3 G A 2: 154,137,582 C209Y probably damaging Het
Cep131 T C 11: 120,067,163 E779G probably benign Het
Cep85 T C 4: 134,152,255 Q394R probably damaging Het
Cep85 G T 4: 134,152,256 Q394K probably damaging Het
Clcn6 T C 4: 148,017,535 Y364C probably benign Het
Fetub G A 16: 22,929,641 M1I probably null Het
Greb1 T C 12: 16,701,201 I1003V probably damaging Het
Hsf3 A G X: 96,320,594 probably benign Het
Jcad A G 18: 4,673,312 N358S probably damaging Het
Kndc1 T C 7: 139,913,972 probably benign Het
Lama1 A T 17: 67,752,774 probably benign Het
Mark2 A G 19: 7,281,238 V50A probably benign Het
Mmp7 T C 9: 7,692,228 W35R probably damaging Het
Ndc80 A G 17: 71,499,325 V578A probably benign Het
Nfyc T C 4: 120,781,524 E42G probably damaging Het
Olfr1164 T C 2: 88,093,016 K307E possibly damaging Het
Olfr1504 A T 19: 13,887,358 L284* probably null Het
Olfr344 A G 2: 36,569,221 T208A probably benign Het
Olfr547 A T 7: 102,535,184 I146F probably damaging Het
Olfr935 A T 9: 38,995,100 C112S probably benign Het
Pcdha11 T C 18: 37,185,008 F925L probably damaging Het
Pdcd1 T G 1: 94,040,846 R154S probably benign Het
Pepd T A 7: 34,924,440 D87E probably benign Het
Pfn4 A G 12: 4,770,240 T30A probably benign Het
Pgpep1l A G 7: 68,237,708 M48T possibly damaging Het
Pla2g15 A G 8: 106,163,116 N340S probably benign Het
Plcb4 A G 2: 136,002,627 D155G probably damaging Het
Plg G A 17: 12,404,069 G499S probably damaging Het
Plin3 C T 17: 56,280,799 W305* probably null Het
Polq C A 16: 37,027,903 L291I probably damaging Het
Sdf2l1 T A 16: 17,132,150 H54L probably damaging Het
Slc38a2 C T 15: 96,693,055 D276N possibly damaging Het
Syk A G 13: 52,643,061 T576A probably benign Het
Uso1 T C 5: 92,181,419 F389L probably damaging Het
Wwc2 T A 8: 47,868,633 Y482F unknown Het
Other mutations in Tas2r119
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00577:Tas2r119 APN 15 32177453 missense probably damaging 0.97
IGL01548:Tas2r119 APN 15 32177977 missense probably damaging 1.00
IGL01826:Tas2r119 APN 15 32177402 missense probably damaging 1.00
IGL02432:Tas2r119 APN 15 32177707 missense probably benign 0.06
IGL02585:Tas2r119 APN 15 32177533 missense probably benign 0.04
R2248:Tas2r119 UTSW 15 32178151 missense possibly damaging 0.51
R2432:Tas2r119 UTSW 15 32178019 missense possibly damaging 0.80
R5098:Tas2r119 UTSW 15 32178082 missense probably benign 0.03
R5624:Tas2r119 UTSW 15 32177968 missense probably damaging 1.00
R5819:Tas2r119 UTSW 15 32177306 missense probably damaging 1.00
R5901:Tas2r119 UTSW 15 32177786 missense possibly damaging 0.84
R6363:Tas2r119 UTSW 15 32177888 missense possibly damaging 0.91
R6495:Tas2r119 UTSW 15 32177530 missense probably benign
R6521:Tas2r119 UTSW 15 32178173 missense probably damaging 1.00
R7574:Tas2r119 UTSW 15 32178133 missense probably damaging 1.00
R9004:Tas2r119 UTSW 15 32177963 missense probably damaging 1.00
R9015:Tas2r119 UTSW 15 32178080 missense probably damaging 1.00
R9193:Tas2r119 UTSW 15 32177786 missense probably benign 0.02
X0063:Tas2r119 UTSW 15 32178155 missense possibly damaging 0.95
Posted On 2013-12-03