Incidental Mutation 'IGL01522:Tas2r119'
ID 89428
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r119
Ensembl Gene ENSMUSG00000045267
Gene Name taste receptor, type 2, member 119
Synonyms mt2r19, mGR19, Tas2r19, T2R19
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01522
Quality Score
Status
Chromosome 15
Chromosomal Location 32177435-32178440 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 32178339 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 302 (V302I)
Ref Sequence ENSEMBL: ENSMUSP00000050277 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057633]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000057633
AA Change: V302I

PolyPhen 2 Score 0.148 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000050277
Gene: ENSMUSG00000045267
AA Change: V302I

DomainStartEndE-ValueType
Pfam:TAS2R 1 293 1.1e-90 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts12 T C 15: 11,065,245 (GRCm39) probably null Het
Adamts3 T C 5: 89,850,802 (GRCm39) N579S probably benign Het
Akr1c19 A G 13: 4,289,098 (GRCm39) probably benign Het
Ankrd39 T A 1: 36,581,142 (GRCm39) H69L probably damaging Het
Apcdd1 T A 18: 63,085,186 (GRCm39) M461K possibly damaging Het
Bpifa3 G A 2: 153,979,502 (GRCm39) C209Y probably damaging Het
Cep131 T C 11: 119,957,989 (GRCm39) E779G probably benign Het
Cep85 T C 4: 133,879,566 (GRCm39) Q394R probably damaging Het
Cep85 G T 4: 133,879,567 (GRCm39) Q394K probably damaging Het
Clcn6 T C 4: 148,101,992 (GRCm39) Y364C probably benign Het
Fetub G A 16: 22,748,391 (GRCm39) M1I probably null Het
Greb1 T C 12: 16,751,202 (GRCm39) I1003V probably damaging Het
Hsf3 A G X: 95,364,200 (GRCm39) probably benign Het
Jcad A G 18: 4,673,312 (GRCm39) N358S probably damaging Het
Kndc1 T C 7: 139,493,888 (GRCm39) probably benign Het
Lama1 A T 17: 68,059,769 (GRCm39) probably benign Het
Mark2 A G 19: 7,258,603 (GRCm39) V50A probably benign Het
Mmp7 T C 9: 7,692,229 (GRCm39) W35R probably damaging Het
Ndc80 A G 17: 71,806,320 (GRCm39) V578A probably benign Het
Nfyc T C 4: 120,638,721 (GRCm39) E42G probably damaging Het
Or1j15 A G 2: 36,459,233 (GRCm39) T208A probably benign Het
Or52b4 A T 7: 102,184,391 (GRCm39) I146F probably damaging Het
Or5d37 T C 2: 87,923,360 (GRCm39) K307E possibly damaging Het
Or8g21 A T 9: 38,906,396 (GRCm39) C112S probably benign Het
Or9i16 A T 19: 13,864,722 (GRCm39) L284* probably null Het
Pcdha11 T C 18: 37,318,061 (GRCm39) F925L probably damaging Het
Pdcd1 T G 1: 93,968,571 (GRCm39) R154S probably benign Het
Pepd T A 7: 34,623,865 (GRCm39) D87E probably benign Het
Pfn4 A G 12: 4,820,240 (GRCm39) T30A probably benign Het
Pgpep1l A G 7: 67,887,456 (GRCm39) M48T possibly damaging Het
Pla2g15 A G 8: 106,889,748 (GRCm39) N340S probably benign Het
Plcb4 A G 2: 135,844,547 (GRCm39) D155G probably damaging Het
Plg G A 17: 12,622,956 (GRCm39) G499S probably damaging Het
Plin3 C T 17: 56,587,799 (GRCm39) W305* probably null Het
Polq C A 16: 36,848,265 (GRCm39) L291I probably damaging Het
Sanbr A G 11: 23,532,865 (GRCm39) probably null Het
Sdf2l1 T A 16: 16,950,014 (GRCm39) H54L probably damaging Het
Slc38a2 C T 15: 96,590,936 (GRCm39) D276N possibly damaging Het
Syk A G 13: 52,797,097 (GRCm39) T576A probably benign Het
Uso1 T C 5: 92,329,278 (GRCm39) F389L probably damaging Het
Wwc2 T A 8: 48,321,668 (GRCm39) Y482F unknown Het
Other mutations in Tas2r119
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00577:Tas2r119 APN 15 32,177,599 (GRCm39) missense probably damaging 0.97
IGL01548:Tas2r119 APN 15 32,178,123 (GRCm39) missense probably damaging 1.00
IGL01826:Tas2r119 APN 15 32,177,548 (GRCm39) missense probably damaging 1.00
IGL02432:Tas2r119 APN 15 32,177,853 (GRCm39) missense probably benign 0.06
IGL02585:Tas2r119 APN 15 32,177,679 (GRCm39) missense probably benign 0.04
R2248:Tas2r119 UTSW 15 32,178,297 (GRCm39) missense possibly damaging 0.51
R2432:Tas2r119 UTSW 15 32,178,165 (GRCm39) missense possibly damaging 0.80
R5098:Tas2r119 UTSW 15 32,178,228 (GRCm39) missense probably benign 0.03
R5624:Tas2r119 UTSW 15 32,178,114 (GRCm39) missense probably damaging 1.00
R5819:Tas2r119 UTSW 15 32,177,452 (GRCm39) missense probably damaging 1.00
R5901:Tas2r119 UTSW 15 32,177,932 (GRCm39) missense possibly damaging 0.84
R6363:Tas2r119 UTSW 15 32,178,034 (GRCm39) missense possibly damaging 0.91
R6495:Tas2r119 UTSW 15 32,177,676 (GRCm39) missense probably benign
R6521:Tas2r119 UTSW 15 32,178,319 (GRCm39) missense probably damaging 1.00
R7574:Tas2r119 UTSW 15 32,178,279 (GRCm39) missense probably damaging 1.00
R9004:Tas2r119 UTSW 15 32,178,109 (GRCm39) missense probably damaging 1.00
R9015:Tas2r119 UTSW 15 32,178,226 (GRCm39) missense probably damaging 1.00
R9193:Tas2r119 UTSW 15 32,177,932 (GRCm39) missense probably benign 0.02
X0063:Tas2r119 UTSW 15 32,178,301 (GRCm39) missense possibly damaging 0.95
Posted On 2013-12-03