Incidental Mutation 'IGL01522:Pla2g15'
ID 89433
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pla2g15
Ensembl Gene ENSMUSG00000031903
Gene Name phospholipase A2, group XV
Synonyms Lpla2, LLPL, Lypla3, C87498
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.209) question?
Stock # IGL01522
Quality Score
Chromosome 8
Chromosomal Location 106150399-106164715 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106163116 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 340 (N340S)
Ref Sequence ENSEMBL: ENSMUSP00000034377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034377] [ENSMUST00000212963]
AlphaFold Q8VEB4
Predicted Effect probably benign
Transcript: ENSMUST00000034377
AA Change: N340S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000034377
Gene: ENSMUSG00000031903
AA Change: N340S

signal peptide 1 33 N/A INTRINSIC
Pfam:LCAT 72 399 6.2e-84 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212116
Predicted Effect probably benign
Transcript: ENSMUST00000212963
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutant mice do not develop atherosclerotic lesions even when fed an atherogenic diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik A G 11: 23,582,865 probably null Het
Adamts12 T C 15: 11,065,159 probably null Het
Adamts3 T C 5: 89,702,943 N579S probably benign Het
Akr1c19 A G 13: 4,239,099 probably benign Het
Ankrd39 T A 1: 36,542,061 H69L probably damaging Het
Apcdd1 T A 18: 62,952,115 M461K possibly damaging Het
Bpifa3 G A 2: 154,137,582 C209Y probably damaging Het
Cep131 T C 11: 120,067,163 E779G probably benign Het
Cep85 T C 4: 134,152,255 Q394R probably damaging Het
Cep85 G T 4: 134,152,256 Q394K probably damaging Het
Clcn6 T C 4: 148,017,535 Y364C probably benign Het
Fetub G A 16: 22,929,641 M1I probably null Het
Greb1 T C 12: 16,701,201 I1003V probably damaging Het
Hsf3 A G X: 96,320,594 probably benign Het
Jcad A G 18: 4,673,312 N358S probably damaging Het
Kndc1 T C 7: 139,913,972 probably benign Het
Lama1 A T 17: 67,752,774 probably benign Het
Mark2 A G 19: 7,281,238 V50A probably benign Het
Mmp7 T C 9: 7,692,228 W35R probably damaging Het
Ndc80 A G 17: 71,499,325 V578A probably benign Het
Nfyc T C 4: 120,781,524 E42G probably damaging Het
Olfr1164 T C 2: 88,093,016 K307E possibly damaging Het
Olfr1504 A T 19: 13,887,358 L284* probably null Het
Olfr344 A G 2: 36,569,221 T208A probably benign Het
Olfr547 A T 7: 102,535,184 I146F probably damaging Het
Olfr935 A T 9: 38,995,100 C112S probably benign Het
Pcdha11 T C 18: 37,185,008 F925L probably damaging Het
Pdcd1 T G 1: 94,040,846 R154S probably benign Het
Pepd T A 7: 34,924,440 D87E probably benign Het
Pfn4 A G 12: 4,770,240 T30A probably benign Het
Pgpep1l A G 7: 68,237,708 M48T possibly damaging Het
Plcb4 A G 2: 136,002,627 D155G probably damaging Het
Plg G A 17: 12,404,069 G499S probably damaging Het
Plin3 C T 17: 56,280,799 W305* probably null Het
Polq C A 16: 37,027,903 L291I probably damaging Het
Sdf2l1 T A 16: 17,132,150 H54L probably damaging Het
Slc38a2 C T 15: 96,693,055 D276N possibly damaging Het
Syk A G 13: 52,643,061 T576A probably benign Het
Tas2r119 G A 15: 32,178,193 V302I probably benign Het
Uso1 T C 5: 92,181,419 F389L probably damaging Het
Wwc2 T A 8: 47,868,633 Y482F unknown Het
Other mutations in Pla2g15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02719:Pla2g15 APN 8 106160196 missense probably benign 0.01
IGL03065:Pla2g15 APN 8 106160219 missense probably benign 0.20
R0125:Pla2g15 UTSW 8 106163124 missense probably benign 0.00
R1691:Pla2g15 UTSW 8 106154949 missense possibly damaging 0.93
R1939:Pla2g15 UTSW 8 106163295 missense probably damaging 0.96
R3887:Pla2g15 UTSW 8 106161135 missense probably damaging 0.99
R4633:Pla2g15 UTSW 8 106160255 missense probably damaging 1.00
R4702:Pla2g15 UTSW 8 106163059 missense probably benign 0.08
R4703:Pla2g15 UTSW 8 106163059 missense probably benign 0.08
R4705:Pla2g15 UTSW 8 106163059 missense probably benign 0.08
R4766:Pla2g15 UTSW 8 106163071 missense probably damaging 1.00
R4928:Pla2g15 UTSW 8 106163218 nonsense probably null
R5543:Pla2g15 UTSW 8 106161143 missense probably damaging 0.99
R6489:Pla2g15 UTSW 8 106163194 missense probably benign 0.10
R6802:Pla2g15 UTSW 8 106150581 missense probably damaging 0.99
R7381:Pla2g15 UTSW 8 106162944 missense probably benign 0.03
R9245:Pla2g15 UTSW 8 106162907 missense possibly damaging 0.81
R9302:Pla2g15 UTSW 8 106150569 missense probably benign 0.04
Z1177:Pla2g15 UTSW 8 106162987 missense probably benign 0.19
Posted On 2013-12-03