Incidental Mutation 'IGL01522:Or5d37'
ID 89447
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5d37
Ensembl Gene ENSMUSG00000075136
Gene Name olfactory receptor family 5 subfamily D member 37
Synonyms GA_x6K02T2Q125-49585842-49584862, Olfr1164, MOR174-11
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # IGL01522
Quality Score
Chromosome 2
Chromosomal Location 87923199-87924310 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87923360 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 307 (K307E)
Ref Sequence ENSEMBL: ENSMUSP00000097422 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099834]
AlphaFold A2AVT5
Predicted Effect possibly damaging
Transcript: ENSMUST00000099834
AA Change: K307E

PolyPhen 2 Score 0.480 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000097422
Gene: ENSMUSG00000075136
AA Change: K307E

Pfam:7tm_4 43 320 3.8e-47 PFAM
Pfam:7tm_1 53 302 2.9e-15 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts12 T C 15: 11,065,245 (GRCm39) probably null Het
Adamts3 T C 5: 89,850,802 (GRCm39) N579S probably benign Het
Akr1c19 A G 13: 4,289,098 (GRCm39) probably benign Het
Ankrd39 T A 1: 36,581,142 (GRCm39) H69L probably damaging Het
Apcdd1 T A 18: 63,085,186 (GRCm39) M461K possibly damaging Het
Bpifa3 G A 2: 153,979,502 (GRCm39) C209Y probably damaging Het
Cep131 T C 11: 119,957,989 (GRCm39) E779G probably benign Het
Cep85 T C 4: 133,879,566 (GRCm39) Q394R probably damaging Het
Cep85 G T 4: 133,879,567 (GRCm39) Q394K probably damaging Het
Clcn6 T C 4: 148,101,992 (GRCm39) Y364C probably benign Het
Fetub G A 16: 22,748,391 (GRCm39) M1I probably null Het
Greb1 T C 12: 16,751,202 (GRCm39) I1003V probably damaging Het
Hsf3 A G X: 95,364,200 (GRCm39) probably benign Het
Jcad A G 18: 4,673,312 (GRCm39) N358S probably damaging Het
Kndc1 T C 7: 139,493,888 (GRCm39) probably benign Het
Lama1 A T 17: 68,059,769 (GRCm39) probably benign Het
Mark2 A G 19: 7,258,603 (GRCm39) V50A probably benign Het
Mmp7 T C 9: 7,692,229 (GRCm39) W35R probably damaging Het
Ndc80 A G 17: 71,806,320 (GRCm39) V578A probably benign Het
Nfyc T C 4: 120,638,721 (GRCm39) E42G probably damaging Het
Or1j15 A G 2: 36,459,233 (GRCm39) T208A probably benign Het
Or52b4 A T 7: 102,184,391 (GRCm39) I146F probably damaging Het
Or8g21 A T 9: 38,906,396 (GRCm39) C112S probably benign Het
Or9i16 A T 19: 13,864,722 (GRCm39) L284* probably null Het
Pcdha11 T C 18: 37,318,061 (GRCm39) F925L probably damaging Het
Pdcd1 T G 1: 93,968,571 (GRCm39) R154S probably benign Het
Pepd T A 7: 34,623,865 (GRCm39) D87E probably benign Het
Pfn4 A G 12: 4,820,240 (GRCm39) T30A probably benign Het
Pgpep1l A G 7: 67,887,456 (GRCm39) M48T possibly damaging Het
Pla2g15 A G 8: 106,889,748 (GRCm39) N340S probably benign Het
Plcb4 A G 2: 135,844,547 (GRCm39) D155G probably damaging Het
Plg G A 17: 12,622,956 (GRCm39) G499S probably damaging Het
Plin3 C T 17: 56,587,799 (GRCm39) W305* probably null Het
Polq C A 16: 36,848,265 (GRCm39) L291I probably damaging Het
Sanbr A G 11: 23,532,865 (GRCm39) probably null Het
Sdf2l1 T A 16: 16,950,014 (GRCm39) H54L probably damaging Het
Slc38a2 C T 15: 96,590,936 (GRCm39) D276N possibly damaging Het
Syk A G 13: 52,797,097 (GRCm39) T576A probably benign Het
Tas2r119 G A 15: 32,178,339 (GRCm39) V302I probably benign Het
Uso1 T C 5: 92,329,278 (GRCm39) F389L probably damaging Het
Wwc2 T A 8: 48,321,668 (GRCm39) Y482F unknown Het
Other mutations in Or5d37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02894:Or5d37 APN 2 87,924,107 (GRCm39) missense possibly damaging 0.79
IGL02977:Or5d37 APN 2 87,923,915 (GRCm39) missense probably benign
R0234:Or5d37 UTSW 2 87,923,366 (GRCm39) nonsense probably null
R0234:Or5d37 UTSW 2 87,923,366 (GRCm39) nonsense probably null
R0480:Or5d37 UTSW 2 87,923,972 (GRCm39) missense probably benign
R0644:Or5d37 UTSW 2 87,923,633 (GRCm39) missense probably benign 0.02
R1479:Or5d37 UTSW 2 87,923,630 (GRCm39) missense probably benign 0.05
R2047:Or5d37 UTSW 2 87,924,237 (GRCm39) missense probably benign 0.01
R2311:Or5d37 UTSW 2 87,924,178 (GRCm39) missense probably benign 0.00
R2973:Or5d37 UTSW 2 87,923,458 (GRCm39) missense probably benign 0.00
R3683:Or5d37 UTSW 2 87,923,603 (GRCm39) missense probably damaging 1.00
R3685:Or5d37 UTSW 2 87,923,603 (GRCm39) missense probably damaging 1.00
R4258:Or5d37 UTSW 2 87,923,362 (GRCm39) missense probably damaging 1.00
R4811:Or5d37 UTSW 2 87,923,876 (GRCm39) missense probably benign 0.08
R4970:Or5d37 UTSW 2 87,923,353 (GRCm39) missense probably damaging 1.00
R5112:Or5d37 UTSW 2 87,923,353 (GRCm39) missense probably damaging 1.00
R5258:Or5d37 UTSW 2 87,923,762 (GRCm39) missense probably benign 0.22
R5884:Or5d37 UTSW 2 87,924,140 (GRCm39) missense probably damaging 1.00
R6329:Or5d37 UTSW 2 87,924,008 (GRCm39) missense probably damaging 1.00
R6597:Or5d37 UTSW 2 87,923,413 (GRCm39) missense probably damaging 1.00
R7018:Or5d37 UTSW 2 87,923,600 (GRCm39) missense probably benign 0.00
R7055:Or5d37 UTSW 2 87,924,045 (GRCm39) missense probably damaging 1.00
R7314:Or5d37 UTSW 2 87,923,458 (GRCm39) missense probably benign 0.00
R7350:Or5d37 UTSW 2 87,923,542 (GRCm39) missense probably benign 0.01
R7527:Or5d37 UTSW 2 87,923,954 (GRCm39) missense probably damaging 1.00
R8003:Or5d37 UTSW 2 87,923,589 (GRCm39) nonsense probably null
R8814:Or5d37 UTSW 2 87,923,315 (GRCm39) missense probably benign
R9072:Or5d37 UTSW 2 87,924,172 (GRCm39) missense probably benign 0.25
R9073:Or5d37 UTSW 2 87,924,172 (GRCm39) missense probably benign 0.25
R9189:Or5d37 UTSW 2 87,924,194 (GRCm39) missense probably damaging 1.00
R9276:Or5d37 UTSW 2 87,923,806 (GRCm39) missense probably benign
R9284:Or5d37 UTSW 2 87,924,278 (GRCm39) start codon destroyed probably benign
Z1176:Or5d37 UTSW 2 87,923,678 (GRCm39) missense probably damaging 0.99
Posted On 2013-12-03