Incidental Mutation 'IGL01524:Myo1f'
ID 89508
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Myo1f
Ensembl Gene ENSMUSG00000024300
Gene Name myosin IF
Synonyms C330006B10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.143) question?
Stock # IGL01524
Quality Score
Status
Chromosome 17
Chromosomal Location 33774681-33826738 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 33798857 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 174 (I174N)
Ref Sequence ENSEMBL: ENSMUSP00000134715 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087605] [ENSMUST00000173372] [ENSMUST00000174695]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000087605
AA Change: I174N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000084887
Gene: ENSMUSG00000024300
AA Change: I174N

DomainStartEndE-ValueType
MYSc 11 691 N/A SMART
IQ 692 714 7.57e0 SMART
Pfam:Myosin_TH1 717 909 1.7e-51 PFAM
low complexity region 939 952 N/A INTRINSIC
low complexity region 973 987 N/A INTRINSIC
low complexity region 991 1001 N/A INTRINSIC
SH3 1044 1098 2.09e-19 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000173372
AA Change: I174N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134715
Gene: ENSMUSG00000024300
AA Change: I174N

DomainStartEndE-ValueType
MYSc 11 691 N/A SMART
IQ 692 714 7.57e0 SMART
Pfam:Myosin_TH1 716 780 6e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173426
Predicted Effect probably benign
Transcript: ENSMUST00000174695
SMART Domains Protein: ENSMUSP00000134600
Gene: ENSMUSG00000024300

DomainStartEndE-ValueType
Pfam:Myosin_head 47 98 1.3e-21 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired neutrophil migration and adhesion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadat A T 8: 60,969,106 (GRCm39) D117V probably damaging Het
Abca14 T C 7: 119,852,644 (GRCm39) Y870H possibly damaging Het
Ankrd36 T C 11: 5,585,092 (GRCm39) I301T probably benign Het
Atp10b T A 11: 43,150,672 (GRCm39) S1457T probably benign Het
Bltp1 A G 3: 36,996,531 (GRCm39) D1081G possibly damaging Het
Ccdc175 G A 12: 72,177,916 (GRCm39) probably benign Het
Ccdc93 A G 1: 121,389,628 (GRCm39) K224E probably benign Het
Cep131 C T 11: 119,956,786 (GRCm39) A886T probably damaging Het
Clip1 A C 5: 123,717,442 (GRCm39) H1282Q probably damaging Het
Ctcfl T G 2: 172,959,177 (GRCm39) D183A probably benign Het
Cyp17a1 C T 19: 46,659,495 (GRCm39) V112I probably benign Het
Fhod3 T C 18: 25,263,659 (GRCm39) I1521T probably damaging Het
Gipc2 A G 3: 151,843,214 (GRCm39) I141T probably damaging Het
Glo1 T C 17: 30,815,393 (GRCm39) R141G possibly damaging Het
Ipmk C A 10: 71,208,631 (GRCm39) A140E probably damaging Het
Kynu A G 2: 43,561,394 (GRCm39) D310G possibly damaging Het
Nat10 T A 2: 103,588,102 (GRCm39) N8Y probably damaging Het
Nhlrc2 A G 19: 56,564,587 (GRCm39) I304V probably benign Het
Pdk4 T C 6: 5,491,979 (GRCm39) H31R probably damaging Het
Sema6d T C 2: 124,505,995 (GRCm39) V644A possibly damaging Het
Slc30a4 T A 2: 122,544,308 (GRCm39) K11N possibly damaging Het
Slc6a3 T C 13: 73,686,668 (GRCm39) S12P probably benign Het
Spats2 C T 15: 99,110,127 (GRCm39) A508V probably benign Het
Tinag A G 9: 76,952,820 (GRCm39) Y55H probably damaging Het
Topbp1 T C 9: 103,188,844 (GRCm39) I172T possibly damaging Het
Trim17 A G 11: 58,861,423 (GRCm39) T279A probably damaging Het
Vmn1r216 C A 13: 23,283,519 (GRCm39) N67K probably benign Het
Washc4 T C 10: 83,411,996 (GRCm39) L709P probably benign Het
Xdh T C 17: 74,230,132 (GRCm39) probably null Het
Zfhx4 C T 3: 5,309,036 (GRCm39) P754L probably damaging Het
Zfp267 T C 3: 36,218,729 (GRCm39) Y251H possibly damaging Het
Zfp623 C A 15: 75,819,528 (GRCm39) S161R probably benign Het
Zmat3 G A 3: 32,395,827 (GRCm39) R227C possibly damaging Het
Other mutations in Myo1f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00851:Myo1f APN 17 33,800,938 (GRCm39) missense probably benign 0.01
IGL01019:Myo1f APN 17 33,811,977 (GRCm39) missense possibly damaging 0.93
IGL01744:Myo1f APN 17 33,802,654 (GRCm39) splice site probably benign
IGL01951:Myo1f APN 17 33,816,991 (GRCm39) missense possibly damaging 0.64
IGL02132:Myo1f APN 17 33,798,945 (GRCm39) missense probably benign 0.10
IGL02170:Myo1f APN 17 33,797,246 (GRCm39) missense probably benign 0.14
IGL02173:Myo1f APN 17 33,826,318 (GRCm39) missense probably damaging 1.00
IGL02277:Myo1f APN 17 33,798,835 (GRCm39) splice site probably null
IGL02550:Myo1f APN 17 33,799,124 (GRCm39) unclassified probably benign
IGL02550:Myo1f APN 17 33,807,116 (GRCm39) missense probably damaging 1.00
IGL02615:Myo1f APN 17 33,823,630 (GRCm39) missense probably benign
IGL02801:Myo1f APN 17 33,797,111 (GRCm39) missense probably damaging 1.00
IGL02817:Myo1f APN 17 33,823,532 (GRCm39) missense probably benign 0.06
IGL02904:Myo1f APN 17 33,804,632 (GRCm39) nonsense probably null
IGL03056:Myo1f APN 17 33,804,574 (GRCm39) missense probably damaging 1.00
IGL03334:Myo1f APN 17 33,817,168 (GRCm39) missense probably damaging 1.00
R0066:Myo1f UTSW 17 33,820,677 (GRCm39) missense probably damaging 0.98
R0066:Myo1f UTSW 17 33,820,677 (GRCm39) missense probably damaging 0.98
R0321:Myo1f UTSW 17 33,811,986 (GRCm39) missense probably benign 0.31
R0375:Myo1f UTSW 17 33,820,930 (GRCm39) missense probably benign 0.27
R0487:Myo1f UTSW 17 33,797,258 (GRCm39) missense probably damaging 1.00
R0925:Myo1f UTSW 17 33,797,107 (GRCm39) missense probably damaging 0.96
R1394:Myo1f UTSW 17 33,802,714 (GRCm39) missense probably damaging 0.96
R1395:Myo1f UTSW 17 33,802,714 (GRCm39) missense probably damaging 0.96
R1474:Myo1f UTSW 17 33,813,001 (GRCm39) missense possibly damaging 0.77
R1760:Myo1f UTSW 17 33,805,172 (GRCm39) missense probably benign 0.03
R1965:Myo1f UTSW 17 33,817,146 (GRCm39) nonsense probably null
R2409:Myo1f UTSW 17 33,795,641 (GRCm39) missense probably damaging 1.00
R2432:Myo1f UTSW 17 33,794,823 (GRCm39) missense probably damaging 1.00
R4610:Myo1f UTSW 17 33,801,306 (GRCm39) missense probably damaging 1.00
R4785:Myo1f UTSW 17 33,817,165 (GRCm39) missense possibly damaging 0.95
R5239:Myo1f UTSW 17 33,820,709 (GRCm39) missense probably benign 0.00
R5881:Myo1f UTSW 17 33,799,259 (GRCm39) missense possibly damaging 0.46
R5881:Myo1f UTSW 17 33,795,627 (GRCm39) missense probably damaging 1.00
R6160:Myo1f UTSW 17 33,823,318 (GRCm39) missense probably benign
R6210:Myo1f UTSW 17 33,820,044 (GRCm39) missense probably damaging 1.00
R6365:Myo1f UTSW 17 33,805,090 (GRCm39) missense probably benign
R6464:Myo1f UTSW 17 33,795,621 (GRCm39) missense probably damaging 1.00
R6532:Myo1f UTSW 17 33,794,820 (GRCm39) missense probably damaging 1.00
R6678:Myo1f UTSW 17 33,794,819 (GRCm39) missense probably damaging 1.00
R7241:Myo1f UTSW 17 33,798,902 (GRCm39) missense probably damaging 0.99
R7266:Myo1f UTSW 17 33,820,668 (GRCm39) missense probably benign
R7513:Myo1f UTSW 17 33,794,788 (GRCm39) missense probably damaging 1.00
R7606:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R7779:Myo1f UTSW 17 33,797,247 (GRCm39) missense probably benign 0.27
R7853:Myo1f UTSW 17 33,795,672 (GRCm39) missense probably damaging 1.00
R7884:Myo1f UTSW 17 33,817,270 (GRCm39) missense probably damaging 1.00
R8507:Myo1f UTSW 17 33,816,992 (GRCm39) missense probably benign 0.09
R8807:Myo1f UTSW 17 33,794,879 (GRCm39) missense probably damaging 1.00
R9009:Myo1f UTSW 17 33,823,662 (GRCm39) missense probably benign 0.12
R9083:Myo1f UTSW 17 33,813,036 (GRCm39) missense probably damaging 0.99
R9227:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R9230:Myo1f UTSW 17 33,795,424 (GRCm39) missense probably damaging 1.00
R9528:Myo1f UTSW 17 33,797,156 (GRCm39) critical splice donor site probably null
X0028:Myo1f UTSW 17 33,795,412 (GRCm39) missense possibly damaging 0.67
X0065:Myo1f UTSW 17 33,820,957 (GRCm39) missense probably benign
Posted On 2013-12-03