Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01524:Zfp623'

89518

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp623

Ensembl Gene

ENSMUSG00000050846

Gene Name

zinc finger protein 623

Synonyms

2610029D06Rik

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.594) question?

Stock #

IGL01524

Quality Score

Status

Chromosome

Chromosomal Location

75940952-75949400 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 75947679 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 161 (S161R)

Ref Sequence

ENSEMBL: ENSMUSP00000036049 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037260]

AlphaFold

Q9CY99

Predicted Effect

probably benign
Transcript: ENSMUST00000037260
AA Change: S161R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000036049
Gene: ENSMUSG00000050846
AA Change: S161R

Domain	Start	End	E-Value	Type
ZnF_C2H2	119	141	5.59e-4	SMART
ZnF_C2H2	147	169	9.96e-1	SMART
ZnF_C2H2	175	197	2.4e-3	SMART
ZnF_C2H2	203	225	6.42e-4	SMART
ZnF_C2H2	231	253	1.3e-4	SMART
ZnF_C2H2	259	281	1.3e-4	SMART
ZnF_C2H2	287	309	1.28e-3	SMART
ZnF_C2H2	315	337	3.21e-4	SMART
ZnF_C2H2	343	365	3.39e-3	SMART
ZnF_C2H2	371	393	4.87e-4	SMART
ZnF_C2H2	399	421	2.53e-2	SMART
ZnF_C2H2	427	449	3.95e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	A	G	3: 36,942,382	D1081G	possibly damaging	Het
Aadat	A	T	8: 60,516,072	D117V	probably damaging	Het
Abca14	T	C	7: 120,253,421	Y870H	possibly damaging	Het
Ankrd36	T	C	11: 5,635,092	I301T	probably benign	Het
Atp10b	T	A	11: 43,259,845	S1457T	probably benign	Het
Ccdc175	G	A	12: 72,131,142		probably benign	Het
Ccdc93	A	G	1: 121,461,899	K224E	probably benign	Het
Cep131	C	T	11: 120,065,960	A886T	probably damaging	Het
Clip1	A	C	5: 123,579,379	H1282Q	probably damaging	Het
Ctcfl	T	G	2: 173,117,384	D183A	probably benign	Het
Cyp17a1	C	T	19: 46,671,056	V112I	probably benign	Het
D3Ertd254e	T	C	3: 36,164,580	Y251H	possibly damaging	Het
Fhod3	T	C	18: 25,130,602	I1521T	probably damaging	Het
Gipc2	A	G	3: 152,137,577	I141T	probably damaging	Het
Glo1	T	C	17: 30,596,419	R141G	possibly damaging	Het
Ipmk	C	A	10: 71,372,801	A140E	probably damaging	Het
Kynu	A	G	2: 43,671,382	D310G	possibly damaging	Het
Myo1f	T	A	17: 33,579,883	I174N	probably damaging	Het
Nat10	T	A	2: 103,757,757	N8Y	probably damaging	Het
Nhlrc2	A	G	19: 56,576,155	I304V	probably benign	Het
Pdk4	T	C	6: 5,491,979	H31R	probably damaging	Het
Sema6d	T	C	2: 124,664,075	V644A	possibly damaging	Het
Slc30a4	T	A	2: 122,702,388	K11N	possibly damaging	Het
Slc6a3	T	C	13: 73,538,549	S12P	probably benign	Het
Spats2	C	T	15: 99,212,246	A508V	probably benign	Het
Tinag	A	G	9: 77,045,538	Y55H	probably damaging	Het
Topbp1	T	C	9: 103,311,645	I172T	possibly damaging	Het
Trim17	A	G	11: 58,970,597	T279A	probably damaging	Het
Vmn1r216	C	A	13: 23,099,349	N67K	probably benign	Het
Washc4	T	C	10: 83,576,132	L709P	probably benign	Het
Xdh	T	C	17: 73,923,137		probably null	Het
Zfhx4	C	T	3: 5,243,976	P754L	probably damaging	Het
Zmat3	G	A	3: 32,341,678	R227C	possibly damaging	Het

Other mutations in Zfp623

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Zfp623	APN	15	75948203	missense	probably damaging	1.00
IGL01927:Zfp623	APN	15	75947505	missense	possibly damaging	0.57
IGL03199:Zfp623	APN	15	75947270	missense	probably benign	0.40
R0076:Zfp623	UTSW	15	75947209	missense	probably benign
R0352:Zfp623	UTSW	15	75948584	missense	probably benign	0.00
R0360:Zfp623	UTSW	15	75948661	missense	probably benign
R0364:Zfp623	UTSW	15	75948661	missense	probably benign
R1783:Zfp623	UTSW	15	75947911	missense	probably damaging	0.99
R2219:Zfp623	UTSW	15	75947530	missense	possibly damaging	0.90
R5975:Zfp623	UTSW	15	75948163	missense	probably benign	0.43
R6161:Zfp623	UTSW	15	75948621	missense	probably benign	0.22
R6342:Zfp623	UTSW	15	75947988	nonsense	probably null
R6490:Zfp623	UTSW	15	75948459	missense	probably damaging	1.00
R6513:Zfp623	UTSW	15	75947468	missense	probably benign
R7028:Zfp623	UTSW	15	75948305	missense	probably damaging	0.99
R7399:Zfp623	UTSW	15	75947398	missense	probably damaging	0.98
R7716:Zfp623	UTSW	15	75948422	missense	probably damaging	1.00
R8362:Zfp623	UTSW	15	75947639	missense	probably damaging	1.00
R8445:Zfp623	UTSW	15	75947553	nonsense	probably null
R9028:Zfp623	UTSW	15	75947500	missense	probably damaging	0.97
R9035:Zfp623	UTSW	15	75948313	missense	possibly damaging	0.93
R9310:Zfp623	UTSW	15	75948100	missense	probably damaging	1.00

Posted On

2013-12-03