Incidental Mutation 'IGL01524:Zfp267'
ID |
89519 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Zfp267
|
Ensembl Gene |
ENSMUSG00000033883 |
Gene Name |
zinc finger protein 267 |
Synonyms |
D3Ertd254e |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.128)
|
Stock # |
IGL01524
|
Quality Score |
|
Status
|
|
Chromosome |
3 |
Chromosomal Location |
36205233-36224491 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 36218729 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Histidine
at position 251
(Y251H)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000142829
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165956]
[ENSMUST00000197653]
[ENSMUST00000205077]
|
AlphaFold |
A0A0G2JEM5 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000165956
AA Change: Y250H
PolyPhen 2
Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000131779 Gene: ENSMUSG00000033883 AA Change: Y250H
Domain | Start | End | E-Value | Type |
KRAB
|
3 |
63 |
2.91e-34 |
SMART |
ZnF_C2H2
|
342 |
364 |
1.08e-1 |
SMART |
ZnF_C2H2
|
395 |
417 |
1.56e-2 |
SMART |
ZnF_C2H2
|
423 |
445 |
3.11e-2 |
SMART |
ZnF_C2H2
|
451 |
473 |
5.9e-3 |
SMART |
ZnF_C2H2
|
479 |
501 |
1.82e-3 |
SMART |
ZnF_C2H2
|
507 |
529 |
5.21e-4 |
SMART |
ZnF_C2H2
|
535 |
557 |
1.84e-4 |
SMART |
ZnF_C2H2
|
563 |
585 |
1.95e-3 |
SMART |
ZnF_C2H2
|
591 |
613 |
2.05e-2 |
SMART |
ZnF_C2H2
|
619 |
641 |
1.6e-4 |
SMART |
ZnF_C2H2
|
647 |
669 |
5.21e-4 |
SMART |
ZnF_C2H2
|
675 |
697 |
1.69e-3 |
SMART |
ZnF_C2H2
|
703 |
725 |
2.61e-4 |
SMART |
ZnF_C2H2
|
731 |
753 |
1.12e-3 |
SMART |
ZnF_C2H2
|
759 |
779 |
3.85e1 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000197653
AA Change: Y251H
PolyPhen 2
Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000142829 Gene: ENSMUSG00000033883 AA Change: Y251H
Domain | Start | End | E-Value | Type |
KRAB
|
4 |
64 |
1.2e-36 |
SMART |
ZnF_C2H2
|
343 |
365 |
4.4e-4 |
SMART |
ZnF_C2H2
|
396 |
418 |
6.7e-5 |
SMART |
ZnF_C2H2
|
424 |
446 |
1.3e-4 |
SMART |
ZnF_C2H2
|
452 |
474 |
2.5e-5 |
SMART |
ZnF_C2H2
|
480 |
502 |
7.9e-6 |
SMART |
ZnF_C2H2
|
508 |
530 |
2.2e-6 |
SMART |
ZnF_C2H2
|
536 |
558 |
7.7e-7 |
SMART |
ZnF_C2H2
|
564 |
586 |
8e-6 |
SMART |
ZnF_C2H2
|
592 |
614 |
8.9e-5 |
SMART |
ZnF_C2H2
|
620 |
642 |
6.6e-7 |
SMART |
ZnF_C2H2
|
648 |
670 |
2.2e-6 |
SMART |
ZnF_C2H2
|
676 |
698 |
7.1e-6 |
SMART |
ZnF_C2H2
|
704 |
726 |
1.1e-6 |
SMART |
ZnF_C2H2
|
732 |
754 |
4.8e-6 |
SMART |
ZnF_C2H2
|
760 |
780 |
1.6e-1 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000205077
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadat |
A |
T |
8: 60,969,106 (GRCm39) |
D117V |
probably damaging |
Het |
Abca14 |
T |
C |
7: 119,852,644 (GRCm39) |
Y870H |
possibly damaging |
Het |
Ankrd36 |
T |
C |
11: 5,585,092 (GRCm39) |
I301T |
probably benign |
Het |
Atp10b |
T |
A |
11: 43,150,672 (GRCm39) |
S1457T |
probably benign |
Het |
Bltp1 |
A |
G |
3: 36,996,531 (GRCm39) |
D1081G |
possibly damaging |
Het |
Ccdc175 |
G |
A |
12: 72,177,916 (GRCm39) |
|
probably benign |
Het |
Ccdc93 |
A |
G |
1: 121,389,628 (GRCm39) |
K224E |
probably benign |
Het |
Cep131 |
C |
T |
11: 119,956,786 (GRCm39) |
A886T |
probably damaging |
Het |
Clip1 |
A |
C |
5: 123,717,442 (GRCm39) |
H1282Q |
probably damaging |
Het |
Ctcfl |
T |
G |
2: 172,959,177 (GRCm39) |
D183A |
probably benign |
Het |
Cyp17a1 |
C |
T |
19: 46,659,495 (GRCm39) |
V112I |
probably benign |
Het |
Fhod3 |
T |
C |
18: 25,263,659 (GRCm39) |
I1521T |
probably damaging |
Het |
Gipc2 |
A |
G |
3: 151,843,214 (GRCm39) |
I141T |
probably damaging |
Het |
Glo1 |
T |
C |
17: 30,815,393 (GRCm39) |
R141G |
possibly damaging |
Het |
Ipmk |
C |
A |
10: 71,208,631 (GRCm39) |
A140E |
probably damaging |
Het |
Kynu |
A |
G |
2: 43,561,394 (GRCm39) |
D310G |
possibly damaging |
Het |
Myo1f |
T |
A |
17: 33,798,857 (GRCm39) |
I174N |
probably damaging |
Het |
Nat10 |
T |
A |
2: 103,588,102 (GRCm39) |
N8Y |
probably damaging |
Het |
Nhlrc2 |
A |
G |
19: 56,564,587 (GRCm39) |
I304V |
probably benign |
Het |
Pdk4 |
T |
C |
6: 5,491,979 (GRCm39) |
H31R |
probably damaging |
Het |
Sema6d |
T |
C |
2: 124,505,995 (GRCm39) |
V644A |
possibly damaging |
Het |
Slc30a4 |
T |
A |
2: 122,544,308 (GRCm39) |
K11N |
possibly damaging |
Het |
Slc6a3 |
T |
C |
13: 73,686,668 (GRCm39) |
S12P |
probably benign |
Het |
Spats2 |
C |
T |
15: 99,110,127 (GRCm39) |
A508V |
probably benign |
Het |
Tinag |
A |
G |
9: 76,952,820 (GRCm39) |
Y55H |
probably damaging |
Het |
Topbp1 |
T |
C |
9: 103,188,844 (GRCm39) |
I172T |
possibly damaging |
Het |
Trim17 |
A |
G |
11: 58,861,423 (GRCm39) |
T279A |
probably damaging |
Het |
Vmn1r216 |
C |
A |
13: 23,283,519 (GRCm39) |
N67K |
probably benign |
Het |
Washc4 |
T |
C |
10: 83,411,996 (GRCm39) |
L709P |
probably benign |
Het |
Xdh |
T |
C |
17: 74,230,132 (GRCm39) |
|
probably null |
Het |
Zfhx4 |
C |
T |
3: 5,309,036 (GRCm39) |
P754L |
probably damaging |
Het |
Zfp623 |
C |
A |
15: 75,819,528 (GRCm39) |
S161R |
probably benign |
Het |
Zmat3 |
G |
A |
3: 32,395,827 (GRCm39) |
R227C |
possibly damaging |
Het |
|
Other mutations in Zfp267 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02089:Zfp267
|
APN |
3 |
36,218,877 (GRCm39) |
missense |
possibly damaging |
0.53 |
IGL02162:Zfp267
|
APN |
3 |
36,218,210 (GRCm39) |
missense |
probably benign |
0.18 |
R0243:Zfp267
|
UTSW |
3 |
36,219,303 (GRCm39) |
missense |
possibly damaging |
0.47 |
R0512:Zfp267
|
UTSW |
3 |
36,220,262 (GRCm39) |
missense |
probably damaging |
0.96 |
R0722:Zfp267
|
UTSW |
3 |
36,219,218 (GRCm39) |
missense |
probably benign |
0.35 |
R0762:Zfp267
|
UTSW |
3 |
36,220,016 (GRCm39) |
missense |
possibly damaging |
0.92 |
R0792:Zfp267
|
UTSW |
3 |
36,218,711 (GRCm39) |
missense |
probably benign |
0.01 |
R0894:Zfp267
|
UTSW |
3 |
36,218,935 (GRCm39) |
nonsense |
probably null |
|
R1731:Zfp267
|
UTSW |
3 |
36,218,620 (GRCm39) |
missense |
probably benign |
0.18 |
R2098:Zfp267
|
UTSW |
3 |
36,220,289 (GRCm39) |
missense |
probably benign |
|
R2099:Zfp267
|
UTSW |
3 |
36,218,361 (GRCm39) |
missense |
possibly damaging |
0.86 |
R3709:Zfp267
|
UTSW |
3 |
36,213,725 (GRCm39) |
missense |
possibly damaging |
0.71 |
R3808:Zfp267
|
UTSW |
3 |
36,219,792 (GRCm39) |
splice site |
probably null |
|
R4035:Zfp267
|
UTSW |
3 |
36,218,989 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4288:Zfp267
|
UTSW |
3 |
36,213,747 (GRCm39) |
missense |
possibly damaging |
0.71 |
R4289:Zfp267
|
UTSW |
3 |
36,213,747 (GRCm39) |
missense |
possibly damaging |
0.71 |
R4959:Zfp267
|
UTSW |
3 |
36,218,285 (GRCm39) |
missense |
possibly damaging |
0.91 |
R4973:Zfp267
|
UTSW |
3 |
36,218,285 (GRCm39) |
missense |
possibly damaging |
0.91 |
R5102:Zfp267
|
UTSW |
3 |
36,216,814 (GRCm39) |
missense |
possibly damaging |
0.73 |
R5462:Zfp267
|
UTSW |
3 |
36,219,969 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5548:Zfp267
|
UTSW |
3 |
36,219,640 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5782:Zfp267
|
UTSW |
3 |
36,219,128 (GRCm39) |
missense |
possibly damaging |
0.73 |
R6153:Zfp267
|
UTSW |
3 |
36,219,303 (GRCm39) |
missense |
possibly damaging |
0.47 |
R6225:Zfp267
|
UTSW |
3 |
36,220,352 (GRCm39) |
missense |
probably benign |
0.18 |
R6602:Zfp267
|
UTSW |
3 |
36,219,004 (GRCm39) |
missense |
possibly damaging |
0.86 |
R6785:Zfp267
|
UTSW |
3 |
36,219,601 (GRCm39) |
nonsense |
probably null |
|
R7513:Zfp267
|
UTSW |
3 |
36,218,792 (GRCm39) |
missense |
possibly damaging |
0.53 |
R7846:Zfp267
|
UTSW |
3 |
36,219,738 (GRCm39) |
missense |
probably benign |
0.43 |
R8120:Zfp267
|
UTSW |
3 |
36,218,640 (GRCm39) |
missense |
possibly damaging |
0.96 |
R8265:Zfp267
|
UTSW |
3 |
36,213,677 (GRCm39) |
start gained |
probably benign |
|
R8415:Zfp267
|
UTSW |
3 |
36,219,182 (GRCm39) |
missense |
probably damaging |
0.98 |
R8826:Zfp267
|
UTSW |
3 |
36,218,255 (GRCm39) |
missense |
possibly damaging |
0.86 |
R9026:Zfp267
|
UTSW |
3 |
36,219,066 (GRCm39) |
missense |
possibly damaging |
0.96 |
R9159:Zfp267
|
UTSW |
3 |
36,219,902 (GRCm39) |
missense |
possibly damaging |
0.47 |
R9786:Zfp267
|
UTSW |
3 |
36,219,853 (GRCm39) |
nonsense |
probably null |
|
X0021:Zfp267
|
UTSW |
3 |
36,218,340 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Posted On |
2013-12-03 |