Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01527:Vmn2r17'

89586

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r17

Ensembl Gene

ENSMUSG00000091879

Gene Name

vomeronasal 2, receptor 17

Synonyms

EG384221

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.102) question?

Stock #

IGL01527

Quality Score

Status

Chromosome

Chromosomal Location

109420013-109453387 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109453140 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Histidine at position 768 (L768H)

Ref Sequence

ENSEMBL: ENSMUSP00000131450 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171841]

AlphaFold

E9PYF5

Predicted Effect

probably damaging
Transcript: ENSMUST00000171841
AA Change: L768H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: L768H

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	465	7e-26	PFAM
Pfam:NCD3G	508	562	3.5e-18	PFAM
Pfam:7tm_3	593	830	4.8e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2300002M23Rik	G	T	17: 35,567,833		probably null	Het
Abca13	T	A	11: 9,290,788	W884R	possibly damaging	Het
Ahi1	T	C	10: 20,960,085		probably benign	Het
Ankfn1	G	T	11: 89,391,639	P394Q	probably benign	Het
AW549877	T	C	15: 3,988,683	Y170C	probably damaging	Het
Cacnb2	T	C	2: 14,984,270	I393T	possibly damaging	Het
Ces1a	G	T	8: 93,045,098	P24T	probably damaging	Het
Col22a1	T	C	15: 71,907,031	E269G	probably damaging	Het
Cyp24a1	A	G	2: 170,496,566	L70P	probably damaging	Het
Cyp8b1	T	C	9: 121,914,995	K424E	probably damaging	Het
Dicer1	G	A	12: 104,691,610	Q1902*	probably null	Het
Dst	T	A	1: 34,247,653	L544Q	probably damaging	Het
Esrp2	T	C	8: 106,132,233	T591A	probably benign	Het
Gap43	C	T	16: 42,292,153	E82K	probably benign	Het
Kif17	G	A	4: 138,269,086	V125I	probably benign	Het
Lancl2	T	C	6: 57,732,322	S370P	probably damaging	Het
Macf1	T	C	4: 123,493,160	I203V	possibly damaging	Het
Mphosph9	A	G	5: 124,283,624		probably benign	Het
Ncapg	A	G	5: 45,672,384	I143V	possibly damaging	Het
Nr3c1	A	G	18: 39,486,637	V199A	probably benign	Het
Obscn	T	A	11: 59,064,417	N3890I	possibly damaging	Het
Olfr130	A	G	17: 38,068,095	N308S	probably benign	Het
Olfr669	T	A	7: 104,938,991	V155E	possibly damaging	Het
Olfr92	A	T	17: 37,111,809	Y58N	probably damaging	Het
Olfr951	A	G	9: 39,393,818	H6R	probably benign	Het
Palmd	C	A	3: 116,927,188	E166*	probably null	Het
Pdzd2	T	C	15: 12,445,664	E327G	probably damaging	Het
Pex13	T	C	11: 23,656,111	T40A	probably benign	Het
Pkd2	T	C	5: 104,498,884		probably benign	Het
Plb1	A	G	5: 32,317,123	T643A	probably damaging	Het
Prlr	T	A	15: 10,329,171	D577E	probably benign	Het
Slc44a3	A	G	3: 121,527,128	C75R	probably damaging	Het
Susd6	A	T	12: 80,874,319	N230I	possibly damaging	Het
Tbx10	A	G	19: 3,998,227	R251G	probably damaging	Het
Ttc30a1	T	C	2: 75,980,516	I408V	probably benign	Het
Uap1l1	A	G	2: 25,363,804		probably null	Het
Ugt2b5	A	G	5: 87,136,209	V308A	possibly damaging	Het
Usp28	C	A	9: 49,025,873	H147Q	probably benign	Het
Vmn1r203	T	C	13: 22,524,277	I76T	possibly damaging	Het
Vmn2r104	A	G	17: 20,042,896	I101T	possibly damaging	Het

Other mutations in Vmn2r17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00325:Vmn2r17	APN	5	109427992	missense	probably benign	0.15
IGL01457:Vmn2r17	APN	5	109453032	missense	probably benign	0.00
IGL01693:Vmn2r17	APN	5	109452518	missense	probably damaging	1.00
IGL01738:Vmn2r17	APN	5	109429498	missense	probably damaging	1.00
IGL01767:Vmn2r17	APN	5	109420037	missense	probably benign	0.01
IGL01932:Vmn2r17	APN	5	109427050	missense	probably benign	0.00
IGL01970:Vmn2r17	APN	5	109427947	missense	probably damaging	0.97
IGL02009:Vmn2r17	APN	5	109452848	missense	possibly damaging	0.67
IGL02365:Vmn2r17	APN	5	109453309	missense	probably damaging	1.00
IGL02385:Vmn2r17	APN	5	109434381	missense	probably damaging	1.00
IGL02457:Vmn2r17	APN	5	109453146	missense	probably damaging	1.00
IGL02646:Vmn2r17	APN	5	109453080	missense	probably damaging	1.00
IGL02741:Vmn2r17	APN	5	109420211	missense	probably benign
IGL03213:Vmn2r17	APN	5	109434390	critical splice donor site	probably null
IGL03216:Vmn2r17	APN	5	109452890	missense	probably damaging	1.00
IGL03342:Vmn2r17	APN	5	109427916	missense	probably damaging	1.00
IGL03408:Vmn2r17	APN	5	109429372	splice site	probably benign
R0349:Vmn2r17	UTSW	5	109428336	missense	probably damaging	1.00
R0418:Vmn2r17	UTSW	5	109452881	missense	probably damaging	1.00
R0800:Vmn2r17	UTSW	5	109427326	splice site	probably benign
R0836:Vmn2r17	UTSW	5	109427956	missense	possibly damaging	0.89
R1715:Vmn2r17	UTSW	5	109428244	missense	probably benign	0.00
R1738:Vmn2r17	UTSW	5	109428511	missense	probably benign	0.10
R1801:Vmn2r17	UTSW	5	109428478	missense	probably damaging	1.00
R2054:Vmn2r17	UTSW	5	109452486	missense	probably damaging	0.98
R2060:Vmn2r17	UTSW	5	109427209	missense	probably benign	0.00
R2192:Vmn2r17	UTSW	5	109434278	missense	possibly damaging	0.81
R2315:Vmn2r17	UTSW	5	109428031	missense	probably damaging	1.00
R2374:Vmn2r17	UTSW	5	109427238	missense	probably benign
R3612:Vmn2r17	UTSW	5	109429597	missense	probably benign	0.00
R3832:Vmn2r17	UTSW	5	109428396	missense	probably damaging	1.00
R4273:Vmn2r17	UTSW	5	109452966	missense	probably benign	0.44
R4494:Vmn2r17	UTSW	5	109428469	missense	probably damaging	1.00
R4597:Vmn2r17	UTSW	5	109429562	missense	probably benign	0.01
R4675:Vmn2r17	UTSW	5	109427183	missense	probably benign	0.00
R4701:Vmn2r17	UTSW	5	109427983	missense	probably damaging	0.99
R4754:Vmn2r17	UTSW	5	109452849	missense	probably damaging	0.99
R4841:Vmn2r17	UTSW	5	109434380	missense	probably damaging	1.00
R4842:Vmn2r17	UTSW	5	109434380	missense	probably damaging	1.00
R4865:Vmn2r17	UTSW	5	109427119	missense	probably damaging	1.00
R4902:Vmn2r17	UTSW	5	109453354	missense	probably benign	0.14
R4989:Vmn2r17	UTSW	5	109427873	missense	probably benign	0.07
R5101:Vmn2r17	UTSW	5	109428351	missense	probably damaging	0.99
R5109:Vmn2r17	UTSW	5	109429476	missense	probably benign	0.06
R5123:Vmn2r17	UTSW	5	109427908	missense	possibly damaging	0.90
R5474:Vmn2r17	UTSW	5	109434284	missense	probably damaging	1.00
R5485:Vmn2r17	UTSW	5	109420106	missense	probably benign	0.06
R5611:Vmn2r17	UTSW	5	109428164	missense	probably damaging	0.97
R5652:Vmn2r17	UTSW	5	109429564	missense	probably benign	0.10
R5717:Vmn2r17	UTSW	5	109427274	missense	possibly damaging	0.94
R5735:Vmn2r17	UTSW	5	109452850	missense	possibly damaging	0.67
R5766:Vmn2r17	UTSW	5	109427273	missense	possibly damaging	0.46
R6645:Vmn2r17	UTSW	5	109428381	missense	probably damaging	1.00
R6786:Vmn2r17	UTSW	5	109427829	missense	probably benign	0.30
R6821:Vmn2r17	UTSW	5	109429465	missense	probably damaging	1.00
R6979:Vmn2r17	UTSW	5	109428399	missense	possibly damaging	0.46
R6984:Vmn2r17	UTSW	5	109452667	missense	probably benign	0.10
R7269:Vmn2r17	UTSW	5	109428471	missense	possibly damaging	0.88
R7509:Vmn2r17	UTSW	5	109427829	missense	probably benign	0.30
R7736:Vmn2r17	UTSW	5	109452891	missense	probably benign	0.05
R7789:Vmn2r17	UTSW	5	109452965	missense	possibly damaging	0.77
R7814:Vmn2r17	UTSW	5	109427873	missense	probably benign	0.07
R7847:Vmn2r17	UTSW	5	109420197	missense	probably damaging	1.00
R7863:Vmn2r17	UTSW	5	109420169	missense	probably benign
R7893:Vmn2r17	UTSW	5	109428078	missense	probably benign	0.05
R8234:Vmn2r17	UTSW	5	109453369	missense	probably benign	0.01
R8382:Vmn2r17	UTSW	5	109428521	missense	probably benign	0.01
R8435:Vmn2r17	UTSW	5	109428306	missense	probably benign	0.01
R8465:Vmn2r17	UTSW	5	109452825	missense	probably damaging	0.99
R8555:Vmn2r17	UTSW	5	109452944	missense	probably damaging	0.99
R8900:Vmn2r17	UTSW	5	109427997	missense	probably benign	0.25
R9293:Vmn2r17	UTSW	5	109452846	missense	probably damaging	1.00
R9308:Vmn2r17	UTSW	5	109452639	missense	probably damaging	0.98
R9378:Vmn2r17	UTSW	5	109427866	missense	possibly damaging	0.94

Posted On

2013-12-03