Incidental Mutation 'IGL01527:Lancl2'
ID89604
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lancl2
Ensembl Gene ENSMUSG00000062190
Gene NameLanC (bacterial lantibiotic synthetase component C)-like 2
Synonyms1700003F10Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01527
Quality Score
Status
Chromosome6
Chromosomal Location57702540-57739439 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 57732322 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 370 (S370P)
Ref Sequence ENSEMBL: ENSMUSP00000121377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050077] [ENSMUST00000072954] [ENSMUST00000127485] [ENSMUST00000153777]
Predicted Effect probably damaging
Transcript: ENSMUST00000050077
AA Change: S379P

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000052146
Gene: ENSMUSG00000062190
AA Change: S379P

DomainStartEndE-ValueType
low complexity region 32 44 N/A INTRINSIC
LANC_like 96 444 2.51e-148 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000072954
AA Change: S379P

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000072723
Gene: ENSMUSG00000062190
AA Change: S379P

DomainStartEndE-ValueType
low complexity region 32 44 N/A INTRINSIC
LANC_like 96 444 2.51e-148 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000127485
SMART Domains Protein: ENSMUSP00000115377
Gene: ENSMUSG00000037788

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:WBP-1 37 106 7e-8 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000153777
AA Change: S370P

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000121377
Gene: ENSMUSG00000062190
AA Change: S370P

DomainStartEndE-ValueType
low complexity region 23 35 N/A INTRINSIC
LANC_like 87 435 2.51e-148 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300002M23Rik G T 17: 35,567,833 probably null Het
Abca13 T A 11: 9,290,788 W884R possibly damaging Het
Ahi1 T C 10: 20,960,085 probably benign Het
Ankfn1 G T 11: 89,391,639 P394Q probably benign Het
AW549877 T C 15: 3,988,683 Y170C probably damaging Het
Cacnb2 T C 2: 14,984,270 I393T possibly damaging Het
Ces1a G T 8: 93,045,098 P24T probably damaging Het
Col22a1 T C 15: 71,907,031 E269G probably damaging Het
Cyp24a1 A G 2: 170,496,566 L70P probably damaging Het
Cyp8b1 T C 9: 121,914,995 K424E probably damaging Het
Dicer1 G A 12: 104,691,610 Q1902* probably null Het
Dst T A 1: 34,247,653 L544Q probably damaging Het
Esrp2 T C 8: 106,132,233 T591A probably benign Het
Gap43 C T 16: 42,292,153 E82K probably benign Het
Kif17 G A 4: 138,269,086 V125I probably benign Het
Macf1 T C 4: 123,493,160 I203V possibly damaging Het
Mphosph9 A G 5: 124,283,624 probably benign Het
Ncapg A G 5: 45,672,384 I143V possibly damaging Het
Nr3c1 A G 18: 39,486,637 V199A probably benign Het
Obscn T A 11: 59,064,417 N3890I possibly damaging Het
Olfr130 A G 17: 38,068,095 N308S probably benign Het
Olfr669 T A 7: 104,938,991 V155E possibly damaging Het
Olfr92 A T 17: 37,111,809 Y58N probably damaging Het
Olfr951 A G 9: 39,393,818 H6R probably benign Het
Palmd C A 3: 116,927,188 E166* probably null Het
Pdzd2 T C 15: 12,445,664 E327G probably damaging Het
Pex13 T C 11: 23,656,111 T40A probably benign Het
Pkd2 T C 5: 104,498,884 probably benign Het
Plb1 A G 5: 32,317,123 T643A probably damaging Het
Prlr T A 15: 10,329,171 D577E probably benign Het
Slc44a3 A G 3: 121,527,128 C75R probably damaging Het
Susd6 A T 12: 80,874,319 N230I possibly damaging Het
Tbx10 A G 19: 3,998,227 R251G probably damaging Het
Ttc30a1 T C 2: 75,980,516 I408V probably benign Het
Uap1l1 A G 2: 25,363,804 probably null Het
Ugt2b5 A G 5: 87,136,209 V308A possibly damaging Het
Usp28 C A 9: 49,025,873 H147Q probably benign Het
Vmn1r203 T C 13: 22,524,277 I76T possibly damaging Het
Vmn2r104 A G 17: 20,042,896 I101T possibly damaging Het
Vmn2r17 T A 5: 109,453,140 L768H probably damaging Het
Other mutations in Lancl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Lancl2 APN 6 57724537 splice site probably benign
IGL00469:Lancl2 APN 6 57734026 missense probably damaging 1.00
IGL00568:Lancl2 APN 6 57723485 splice site probably benign
IGL02086:Lancl2 APN 6 57734039 missense probably damaging 1.00
R0309:Lancl2 UTSW 6 57703132 missense probably damaging 1.00
R4202:Lancl2 UTSW 6 57712992 missense probably benign 0.02
R4468:Lancl2 UTSW 6 57713034 missense probably damaging 1.00
R4469:Lancl2 UTSW 6 57713034 missense probably damaging 1.00
R4729:Lancl2 UTSW 6 57737712 missense probably damaging 1.00
R4823:Lancl2 UTSW 6 57732277 missense probably damaging 1.00
R5296:Lancl2 UTSW 6 57724582 missense probably benign 0.05
R5615:Lancl2 UTSW 6 57722511 missense probably damaging 1.00
R6619:Lancl2 UTSW 6 57722581 missense probably damaging 0.98
R6784:Lancl2 UTSW 6 57703255 missense probably benign
R6873:Lancl2 UTSW 6 57722657 missense possibly damaging 0.86
R7363:Lancl2 UTSW 6 57722679 missense probably benign 0.00
R8018:Lancl2 UTSW 6 57713093 missense probably damaging 1.00
R8204:Lancl2 UTSW 6 57737716 missense probably damaging 1.00
Posted On2013-12-03