Incidental Mutation 'IGL01528:Zranb2'
ID89637
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zranb2
Ensembl Gene ENSMUSG00000028180
Gene Namezinc finger, RAN-binding domain containing 2
SynonymsZis, Zfp265, Znf265
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01528
Quality Score
Status
Chromosome3
Chromosomal Location157534160-157548410 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to C at 157544965 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143533 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029831] [ENSMUST00000106057] [ENSMUST00000106058] [ENSMUST00000184802] [ENSMUST00000198915]
Predicted Effect unknown
Transcript: ENSMUST00000029831
AA Change: S221P
SMART Domains Protein: ENSMUSP00000029831
Gene: ENSMUSG00000028180
AA Change: S221P

DomainStartEndE-ValueType
ZnF_RBZ 11 35 1.02e-2 SMART
ZnF_RBZ 36 54 2.09e-1 SMART
low complexity region 70 82 N/A INTRINSIC
low complexity region 108 145 N/A INTRINSIC
low complexity region 156 293 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083497
Predicted Effect unknown
Transcript: ENSMUST00000106057
AA Change: S258P
SMART Domains Protein: ENSMUSP00000101672
Gene: ENSMUSG00000028180
AA Change: S258P

DomainStartEndE-ValueType
ZnF_RBZ 11 37 1.24e-6 SMART
ZnF_RBZ 77 101 3.11e-7 SMART
low complexity region 117 129 N/A INTRINSIC
low complexity region 155 192 N/A INTRINSIC
low complexity region 203 312 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000106058
AA Change: S258P
SMART Domains Protein: ENSMUSP00000101673
Gene: ENSMUSG00000028180
AA Change: S258P

DomainStartEndE-ValueType
ZnF_RBZ 11 37 1.24e-6 SMART
ZnF_RBZ 77 101 3.11e-7 SMART
low complexity region 117 129 N/A INTRINSIC
low complexity region 155 192 N/A INTRINSIC
low complexity region 203 340 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000106063
AA Change: S135P
SMART Domains Protein: ENSMUSP00000101678
Gene: ENSMUSG00000028180
AA Change: S135P

DomainStartEndE-ValueType
ZnF_RBZ 11 37 8.79e-7 SMART
ZnF_RBZ 67 91 3.11e-7 SMART
low complexity region 107 119 N/A INTRINSIC
low complexity region 145 182 N/A INTRINSIC
low complexity region 193 330 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152882
Predicted Effect probably benign
Transcript: ENSMUST00000184802
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196900
Predicted Effect probably benign
Transcript: ENSMUST00000198915
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AB124611 T A 9: 21,539,894 probably benign Het
Cdc45 A G 16: 18,811,561 F2S probably damaging Het
Cdon A G 9: 35,470,107 R598G possibly damaging Het
Dusp22 C T 13: 30,705,628 T64I probably benign Het
Gfer T A 17: 24,695,929 T47S probably benign Het
Gfra2 T C 14: 70,966,298 S296P possibly damaging Het
Gjb2 G A 14: 57,100,668 L28F probably damaging Het
Gm17782 A G 17: 36,161,790 probably benign Het
Gm2832 T C 14: 41,281,713 V167A unknown Het
Gpr155 A G 2: 73,362,423 probably null Het
Gpr45 A G 1: 43,033,223 H342R probably benign Het
Gsdmd A T 15: 75,863,505 T33S possibly damaging Het
Hal T A 10: 93,497,593 L341Q probably damaging Het
Igfbp7 T G 5: 77,351,332 D273A probably damaging Het
Kdm2a T C 19: 4,343,055 D424G probably benign Het
Kif13a C T 13: 46,864,837 probably benign Het
Krt35 A T 11: 100,094,594 L207Q probably damaging Het
Lrp1b A T 2: 40,919,182 D2572E probably damaging Het
Lrp2 A G 2: 69,492,460 V1848A probably damaging Het
Myo9a T C 9: 59,779,674 Y21H probably damaging Het
Ncan G T 8: 70,110,081 A509E probably benign Het
Olfr450 T C 6: 42,818,274 S268P probably damaging Het
Pde11a G A 2: 76,194,956 probably benign Het
Phf19 G T 2: 34,897,107 D448E probably damaging Het
Ptprj A T 2: 90,452,144 V799D probably damaging Het
Rpgrip1 T A 14: 52,112,177 Y7* probably null Het
Sema3c A G 5: 17,714,415 H483R probably benign Het
Slc4a11 A G 2: 130,685,408 probably benign Het
St3gal1 C A 15: 67,112,617 R103L probably benign Het
Tet2 A T 3: 133,480,298 V1126E possibly damaging Het
Tmem117 A T 15: 95,094,664 I402L probably benign Het
Tmem2 T C 19: 21,835,545 V1038A possibly damaging Het
Ttc28 T A 5: 111,101,960 probably benign Het
Ttn A T 2: 76,871,838 probably benign Het
Vmn1r7 T A 6: 57,024,547 M243L probably benign Het
Wnt1 G T 15: 98,791,833 W167L probably damaging Het
Zfp553 G T 7: 127,236,215 S314I probably damaging Het
Other mutations in Zranb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01115:Zranb2 APN 3 157546691 unclassified probably benign
IGL03008:Zranb2 APN 3 157546665 splice site probably null
R0528:Zranb2 UTSW 3 157534459 missense probably benign 0.26
R0659:Zranb2 UTSW 3 157541763 missense probably benign 0.23
R1170:Zranb2 UTSW 3 157541865 utr 3 prime probably benign
R1673:Zranb2 UTSW 3 157537640 missense probably damaging 1.00
R1885:Zranb2 UTSW 3 157543156 critical splice acceptor site probably null
R4127:Zranb2 UTSW 3 157537590 nonsense probably null
R4610:Zranb2 UTSW 3 157541884 splice site probably benign
R4981:Zranb2 UTSW 3 157546741 unclassified probably benign
R5053:Zranb2 UTSW 3 157541159 missense probably damaging 0.96
R5742:Zranb2 UTSW 3 157540703 nonsense probably null
R5873:Zranb2 UTSW 3 157536383 nonsense probably null
R6086:Zranb2 UTSW 3 157543246 critical splice donor site probably null
R7015:Zranb2 UTSW 3 157536733 critical splice acceptor site probably null
R7547:Zranb2 UTSW 3 157541169 missense possibly damaging 0.93
R7579:Zranb2 UTSW 3 157540672 missense probably damaging 1.00
Posted On2013-12-03