Incidental Mutation 'IGL01529:Olfr944'
ID89665
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr944
Ensembl Gene ENSMUSG00000096555
Gene Nameolfactory receptor 944
SynonymsGA_x6K02T2PVTD-32914568-32915503, MOR171-19
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL01529
Quality Score
Status
Chromosome9
Chromosomal Location39201920-39218421 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 39218131 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 258 (T258I)
Ref Sequence ENSEMBL: ENSMUSP00000150471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079650] [ENSMUST00000213908] [ENSMUST00000215306]
Predicted Effect probably benign
Transcript: ENSMUST00000079650
AA Change: T258I

PolyPhen 2 Score 0.297 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000078595
Gene: ENSMUSG00000096555
AA Change: T258I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.5e-47 PFAM
Pfam:7tm_1 41 290 2.1e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213908
AA Change: T258I

PolyPhen 2 Score 0.297 (Sensitivity: 0.91; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000215306
AA Change: T258I

PolyPhen 2 Score 0.297 (Sensitivity: 0.91; Specificity: 0.89)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd17c A T 7: 84,151,414 I144N possibly damaging Het
Adamts19 T A 18: 58,963,463 H588Q probably damaging Het
Ankrd2 A G 19: 42,039,910 K46E probably damaging Het
Arhgap10 A C 8: 77,346,291 L513V possibly damaging Het
Arhgef12 C A 9: 42,990,055 R817L probably damaging Het
Asxl3 T A 18: 22,517,655 N900K probably damaging Het
Atp9b A T 18: 80,844,611 probably benign Het
Cdc27 T C 11: 104,507,216 N773D probably damaging Het
Cep97 A G 16: 55,930,618 probably benign Het
Ddx58 G A 4: 40,225,685 H194Y probably benign Het
Dgkd T C 1: 87,880,411 F67S probably damaging Het
Dolk T C 2: 30,285,737 T99A probably benign Het
Egfr A T 11: 16,863,014 R165W probably benign Het
Fat2 T A 11: 55,282,156 D2577V probably damaging Het
Hsph1 T C 5: 149,636,034 I15V probably benign Het
Idh2 T C 7: 80,097,945 T276A probably benign Het
Jag1 T C 2: 137,084,977 Y954C probably damaging Het
Kat2a A T 11: 100,711,909 W118R probably damaging Het
Kcnh6 G T 11: 106,020,696 R636L probably benign Het
Klk1b16 G T 7: 44,140,739 K144N probably benign Het
Lrrk2 T A 15: 91,812,313 L2435I possibly damaging Het
Ltbp3 A G 19: 5,747,839 D502G probably benign Het
Ltn1 A T 16: 87,381,471 N1623K probably benign Het
Mcm10 C A 2: 5,008,628 E64D probably benign Het
Med13l A G 5: 118,742,335 N1164S probably damaging Het
Myo1a A G 10: 127,720,660 N1025D probably benign Het
Olfr164 A T 16: 19,286,700 D14E probably benign Het
Pdcd11 A G 19: 47,109,629 N785D probably benign Het
Psmd8 A T 7: 29,179,151 I81N probably damaging Het
Ryr1 C T 7: 29,075,227 G2330R probably damaging Het
Scrib T C 15: 76,049,235 T80A possibly damaging Het
Sergef A T 7: 46,443,518 W356R probably damaging Het
Slc22a19 T C 19: 7,682,935 N370S probably damaging Het
Syde1 A G 10: 78,590,181 S51P probably benign Het
Umodl1 A T 17: 30,996,259 D1019V possibly damaging Het
Vmn2r45 A G 7: 8,483,494 M265T probably benign Het
Other mutations in Olfr944
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01096:Olfr944 APN 9 39218116 missense probably damaging 1.00
IGL03307:Olfr944 APN 9 39218013 missense probably benign 0.03
R0110:Olfr944 UTSW 9 39217728 missense possibly damaging 0.50
R0413:Olfr944 UTSW 9 39218270 missense probably benign 0.25
R0450:Olfr944 UTSW 9 39217728 missense possibly damaging 0.50
R2108:Olfr944 UTSW 9 39218022 missense probably damaging 0.99
R2112:Olfr944 UTSW 9 39217779 missense probably benign 0.01
R4666:Olfr944 UTSW 9 39217846 missense probably damaging 0.97
R5039:Olfr944 UTSW 9 39218114 nonsense probably null
R6384:Olfr944 UTSW 9 39217978 missense probably benign 0.06
R8124:Olfr944 UTSW 9 39217671 missense probably benign
Posted On2013-12-03