Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01532:Vmn2r28'

89782

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r28

Ensembl Gene

ENSMUSG00000066820

Gene Name

vomeronasal 2, receptor 28

Synonyms

EG665255

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.165) question?

Stock #

IGL01532

Quality Score

Status

Chromosome

Chromosomal Location

5483455-5496850 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 5489463 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 459 (I459L)

Ref Sequence

ENSEMBL: ENSMUSP00000083477 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086297]

AlphaFold

L7N203

Predicted Effect

probably benign
Transcript: ENSMUST00000086297
AA Change: I459L

PolyPhen 2 Score 0.155 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000083477
Gene: ENSMUSG00000066820
AA Change: I459L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	470	1.7e-26	PFAM
Pfam:NCD3G	512	565	9.8e-21	PFAM
Pfam:7tm_3	598	833	2.8e-56	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts17	C	A	7: 66,558,349 (GRCm39)	N264K	probably damaging	Het
Adgrl3	C	T	5: 81,842,416 (GRCm39)	T260I	probably damaging	Het
Ambra1	G	T	2: 91,715,977 (GRCm39)	K769N	probably damaging	Het
Arel1	A	G	12: 84,980,936 (GRCm39)	V357A	possibly damaging	Het
Atp11b	T	A	3: 35,903,651 (GRCm39)	C76*	probably null	Het
AW112010	C	A	19: 11,025,433 (GRCm39)		noncoding transcript	Het
Bfar	A	T	16: 13,505,251 (GRCm39)		probably benign	Het
Ccdc70	T	G	8: 22,463,299 (GRCm39)	L30V	probably damaging	Het
Cep20	A	G	16: 14,122,375 (GRCm39)	S130P	probably benign	Het
Chrm5	C	T	2: 112,309,577 (GRCm39)	R513Q	probably benign	Het
Crem	G	A	18: 3,276,732 (GRCm39)	T7I	probably benign	Het
Cyp4f39	C	T	17: 32,689,928 (GRCm39)		probably benign	Het
Dlg5	T	C	14: 24,208,660 (GRCm39)	T849A	probably benign	Het
Dock8	G	T	19: 25,146,805 (GRCm39)	G1428V	probably damaging	Het
Eomes	T	C	9: 118,311,317 (GRCm39)	I380T	probably damaging	Het
Fam13a	T	C	6: 58,917,280 (GRCm39)	D532G	probably damaging	Het
Gm10061	G	T	16: 88,948,190 (GRCm39)	*55L	probably null	Het
Gm27438	T	G	2: 87,083,269 (GRCm39)		probably benign	Het
Gpalpp1	T	C	14: 76,339,942 (GRCm39)	K124E	probably benign	Het
Hgs	T	A	11: 120,368,335 (GRCm39)		probably null	Het
Hpn	T	A	7: 30,802,938 (GRCm39)	M121L	possibly damaging	Het
Il1r1	T	C	1: 40,334,088 (GRCm39)		probably null	Het
Jag2	A	T	12: 112,877,983 (GRCm39)	C583S	probably damaging	Het
Katnal2	T	C	18: 77,099,696 (GRCm39)	H146R	probably benign	Het
Ldah	T	C	12: 8,270,596 (GRCm39)		probably benign	Het
Lvrn	T	A	18: 47,033,551 (GRCm39)	Y921N	probably damaging	Het
Muc5b	A	G	7: 141,423,743 (GRCm39)	Y4572C	possibly damaging	Het
Myo16	A	G	8: 10,450,551 (GRCm39)	S518G	probably benign	Het
Ncf1	T	C	5: 134,255,447 (GRCm39)	N148S	probably benign	Het
Nes	T	G	3: 87,885,654 (GRCm39)	D1260E	possibly damaging	Het
Nup210	C	A	6: 91,062,981 (GRCm39)		probably benign	Het
Or52b4i	T	C	7: 102,191,863 (GRCm39)	L240P	probably damaging	Het
Rnf31	C	A	14: 55,840,080 (GRCm39)	Q968K	probably damaging	Het
Ros1	A	G	10: 51,967,034 (GRCm39)		probably benign	Het
Ryk	T	C	9: 102,774,465 (GRCm39)	Y400H	probably benign	Het
Slc4a5	T	A	6: 83,250,022 (GRCm39)		probably null	Het
Sptssb	A	G	3: 69,728,202 (GRCm39)		probably benign	Het
Sstr5	T	C	17: 25,710,305 (GRCm39)	D308G	probably damaging	Het
Taf2	A	G	15: 54,912,882 (GRCm39)	W493R	possibly damaging	Het
Vti1b	A	C	12: 79,211,912 (GRCm39)	L1W	probably null	Het
Wdr1	T	C	5: 38,692,530 (GRCm39)	Y125C	probably damaging	Het

Other mutations in Vmn2r28

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00095:Vmn2r28	APN	7	5,491,068 (GRCm39)	missense	probably benign	0.12
IGL01061:Vmn2r28	APN	7	5,491,183 (GRCm39)	missense	probably damaging	1.00
IGL01160:Vmn2r28	APN	7	5,489,477 (GRCm39)	missense	probably damaging	0.99
IGL01335:Vmn2r28	APN	7	5,484,087 (GRCm39)	missense	possibly damaging	0.67
IGL01791:Vmn2r28	APN	7	5,491,161 (GRCm39)	missense	probably benign	0.00
IGL01875:Vmn2r28	APN	7	5,484,302 (GRCm39)	missense	probably benign	0.30
IGL02161:Vmn2r28	APN	7	5,491,123 (GRCm39)	missense	possibly damaging	0.88
IGL02499:Vmn2r28	APN	7	5,493,568 (GRCm39)	missense	probably damaging	0.98
IGL02858:Vmn2r28	APN	7	5,484,003 (GRCm39)	missense	probably damaging	0.99
IGL03061:Vmn2r28	APN	7	5,487,015 (GRCm39)	missense	probably damaging	0.98
G1patch:Vmn2r28	UTSW	7	5,491,408 (GRCm39)	missense	probably benign	0.13
R0288:Vmn2r28	UTSW	7	5,491,020 (GRCm39)	missense	probably damaging	1.00
R0361:Vmn2r28	UTSW	7	5,496,715 (GRCm39)	missense	probably benign	0.00
R0396:Vmn2r28	UTSW	7	5,491,513 (GRCm39)	missense	probably benign	0.05
R0480:Vmn2r28	UTSW	7	5,493,456 (GRCm39)	missense	probably benign	0.00
R0485:Vmn2r28	UTSW	7	5,491,689 (GRCm39)	missense	probably damaging	1.00
R0837:Vmn2r28	UTSW	7	5,491,026 (GRCm39)	missense	probably damaging	0.99
R1282:Vmn2r28	UTSW	7	5,484,301 (GRCm39)	missense	probably damaging	0.99
R1296:Vmn2r28	UTSW	7	5,484,544 (GRCm39)	missense	possibly damaging	0.81
R1829:Vmn2r28	UTSW	7	5,496,810 (GRCm39)	missense	probably benign
R1853:Vmn2r28	UTSW	7	5,484,246 (GRCm39)	nonsense	probably null
R1869:Vmn2r28	UTSW	7	5,489,345 (GRCm39)	missense	probably benign	0.00
R1887:Vmn2r28	UTSW	7	5,491,288 (GRCm39)	missense	possibly damaging	0.90
R1961:Vmn2r28	UTSW	7	5,484,070 (GRCm39)	missense	possibly damaging	0.85
R1998:Vmn2r28	UTSW	7	5,491,313 (GRCm39)	missense	possibly damaging	0.87
R2392:Vmn2r28	UTSW	7	5,487,130 (GRCm39)	missense	probably damaging	0.98
R2432:Vmn2r28	UTSW	7	5,491,701 (GRCm39)	missense	probably damaging	0.99
R3055:Vmn2r28	UTSW	7	5,484,391 (GRCm39)	missense	probably damaging	0.98
R3753:Vmn2r28	UTSW	7	5,491,026 (GRCm39)	missense	probably damaging	0.99
R3877:Vmn2r28	UTSW	7	5,491,357 (GRCm39)	missense	probably damaging	1.00
R4307:Vmn2r28	UTSW	7	5,493,707 (GRCm39)	missense	probably damaging	0.99
R5023:Vmn2r28	UTSW	7	5,489,463 (GRCm39)	missense	probably benign	0.16
R5057:Vmn2r28	UTSW	7	5,489,463 (GRCm39)	missense	probably benign	0.16
R5083:Vmn2r28	UTSW	7	5,483,671 (GRCm39)	missense	possibly damaging	0.77
R5427:Vmn2r28	UTSW	7	5,489,376 (GRCm39)	missense	probably damaging	0.99
R5472:Vmn2r28	UTSW	7	5,490,943 (GRCm39)	critical splice donor site	probably null
R5511:Vmn2r28	UTSW	7	5,487,011 (GRCm39)	missense	possibly damaging	0.61
R5731:Vmn2r28	UTSW	7	5,491,668 (GRCm39)	missense	probably benign	0.41
R6091:Vmn2r28	UTSW	7	5,496,790 (GRCm39)	missense	possibly damaging	0.88
R6179:Vmn2r28	UTSW	7	5,491,003 (GRCm39)	nonsense	probably null
R6276:Vmn2r28	UTSW	7	5,493,730 (GRCm39)	missense	probably benign	0.01
R6441:Vmn2r28	UTSW	7	5,491,474 (GRCm39)	missense	probably benign	0.00
R6463:Vmn2r28	UTSW	7	5,489,435 (GRCm39)	missense	probably benign	0.07
R6528:Vmn2r28	UTSW	7	5,493,684 (GRCm39)	missense	probably benign	0.12
R6725:Vmn2r28	UTSW	7	5,491,408 (GRCm39)	missense	probably benign	0.13
R6760:Vmn2r28	UTSW	7	5,484,229 (GRCm39)	missense	probably damaging	0.97
R6849:Vmn2r28	UTSW	7	5,483,806 (GRCm39)	missense	probably damaging	1.00
R7110:Vmn2r28	UTSW	7	5,493,733 (GRCm39)	missense	probably benign	0.06
R7146:Vmn2r28	UTSW	7	5,484,495 (GRCm39)	missense	probably benign	0.05
R7407:Vmn2r28	UTSW	7	5,484,308 (GRCm39)	missense	probably damaging	1.00
R7563:Vmn2r28	UTSW	7	5,491,200 (GRCm39)	missense	probably benign	0.00
R7611:Vmn2r28	UTSW	7	5,484,255 (GRCm39)	missense	probably benign	0.02
R7808:Vmn2r28	UTSW	7	5,496,678 (GRCm39)	missense	probably damaging	0.98
R7862:Vmn2r28	UTSW	7	5,493,613 (GRCm39)	missense	probably benign	0.00
R7916:Vmn2r28	UTSW	7	5,483,818 (GRCm39)	missense	probably damaging	1.00
R8183:Vmn2r28	UTSW	7	5,491,147 (GRCm39)	missense	probably damaging	1.00
R8334:Vmn2r28	UTSW	7	5,487,059 (GRCm39)	missense	probably damaging	1.00
R8519:Vmn2r28	UTSW	7	5,489,347 (GRCm39)	missense	probably benign	0.31
R8989:Vmn2r28	UTSW	7	5,493,473 (GRCm39)	missense	probably benign	0.00
R9066:Vmn2r28	UTSW	7	5,491,596 (GRCm39)	missense	probably damaging	1.00
R9422:Vmn2r28	UTSW	7	5,483,747 (GRCm39)	missense	probably damaging	1.00
R9469:Vmn2r28	UTSW	7	5,487,118 (GRCm39)	missense	probably damaging	0.99
R9608:Vmn2r28	UTSW	7	5,491,220 (GRCm39)	missense	probably benign	0.05

Posted On

2013-12-03