Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01533:Tex264'

89842

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tex264

Ensembl Gene

ENSMUSG00000040813

Gene Name

testis expressed gene 264

Synonyms

TEG-264

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.433) question?

Stock #

IGL01533

Quality Score

Status

Chromosome

Chromosomal Location

106535945-106563126 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106550798 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 133 (I133T)

Ref Sequence

ENSEMBL: ENSMUSP00000133194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046735] [ENSMUST00000163441] [ENSMUST00000169068]

AlphaFold

E9Q137

Predicted Effect

probably benign
Transcript: ENSMUST00000046735
AA Change: I133T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000044654
Gene: ENSMUSG00000040813
AA Change: I133T

Domain	Start	End	E-Value	Type
transmembrane domain	5	27	N/A	INTRINSIC
Pfam:GyrI-like	41	185	1e-12	PFAM
low complexity region	208	225	N/A	INTRINSIC
low complexity region	258	291	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000163441
AA Change: I133T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000132247
Gene: ENSMUSG00000040813
AA Change: I133T

Domain	Start	End	E-Value	Type
transmembrane domain	5	27	N/A	INTRINSIC
SCOP:d1jyha_	46	133	7e-3	SMART
low complexity region	208	225	N/A	INTRINSIC
low complexity region	258	291	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000169068
AA Change: I133T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000133194
Gene: ENSMUSG00000040813
AA Change: I133T

Domain	Start	End	E-Value	Type
transmembrane domain	5	27	N/A	INTRINSIC
Pfam:GyrI-like	41	176	4.2e-11	PFAM
low complexity region	220	253	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185257

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188120

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188892

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190948

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214885

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg3l2	C	A	18: 67,538,488 (GRCm39)	E757*	probably null	Het
Arhgap15	T	C	2: 44,133,165 (GRCm39)	V357A	probably damaging	Het
Asb13	T	C	13: 3,692,164 (GRCm39)	V48A	probably benign	Het
Bbs7	T	C	3: 36,664,384 (GRCm39)	R74G	possibly damaging	Het
Capn11	T	C	17: 45,943,830 (GRCm39)	H568R	probably benign	Het
Cbx5	T	C	15: 103,114,061 (GRCm39)	E61G	probably damaging	Het
Ccdc158	T	C	5: 92,757,815 (GRCm39)		probably null	Het
Col14a1	C	A	15: 55,284,236 (GRCm39)	N832K	unknown	Het
Cyp2a4	A	T	7: 26,007,969 (GRCm39)	K125N	probably damaging	Het
Dhx16	T	C	17: 36,192,939 (GRCm39)	L215P	probably damaging	Het
Dtx4	T	C	19: 12,455,579 (GRCm39)	M480V	possibly damaging	Het
Edaradd	A	G	13: 12,493,463 (GRCm39)		probably benign	Het
Galnt13	T	A	2: 54,770,144 (GRCm39)	M312K	probably damaging	Het
Gcdh	T	A	8: 85,615,991 (GRCm39)	R337W	probably damaging	Het
Gm28557	A	T	13: 67,219,396 (GRCm39)	C109*	probably null	Het
Gpr22	C	T	12: 31,758,709 (GRCm39)		probably benign	Het
Gria4	T	G	9: 4,502,395 (GRCm39)	L379F	probably damaging	Het
Gxylt2	T	C	6: 100,760,098 (GRCm39)	L211P	probably damaging	Het
Igsf10	T	A	3: 59,226,651 (GRCm39)	I2341F	probably damaging	Het
Macf1	T	C	4: 123,367,666 (GRCm39)	D2365G	probably damaging	Het
Morc2b	A	G	17: 33,354,695 (GRCm39)		probably benign	Het
Ncoa3	T	C	2: 165,896,945 (GRCm39)	S579P	probably benign	Het
Nlgn1	T	C	3: 25,490,527 (GRCm39)	N400S	possibly damaging	Het
Or5w17	C	A	2: 87,583,412 (GRCm39)	R308S	probably benign	Het
Or8g17	C	T	9: 38,930,097 (GRCm39)	A247T	probably damaging	Het
Pi4ka	A	G	16: 17,126,065 (GRCm39)	S1102P	probably benign	Het
Polr1e	A	G	4: 45,019,328 (GRCm39)	Y59C	probably damaging	Het
Prex2	C	T	1: 11,256,965 (GRCm39)	Q1226*	probably null	Het
Rab12	A	T	17: 66,804,430 (GRCm39)	I176K	probably damaging	Het
Ryr2	A	T	13: 11,736,676 (GRCm39)	N2250K	probably damaging	Het
Sbf1	T	C	15: 89,172,919 (GRCm39)	T1865A	probably damaging	Het
Sema6b	G	A	17: 56,436,499 (GRCm39)		probably benign	Het
Smarcb1	C	T	10: 75,752,602 (GRCm39)		probably null	Het
Sos1	A	G	17: 80,722,511 (GRCm39)	L845S	probably damaging	Het
Stat4	T	A	1: 52,137,578 (GRCm39)	N456K	probably damaging	Het
Thoc1	T	C	18: 9,962,376 (GRCm39)	V87A	probably benign	Het
Tmem131	C	T	1: 36,857,803 (GRCm39)	D778N	probably damaging	Het
Tspan14	A	G	14: 40,638,776 (GRCm39)	I88T	probably benign	Het
Ttn	C	A	2: 76,562,918 (GRCm39)	V28679L	possibly damaging	Het
Ttn	A	G	2: 76,782,285 (GRCm39)	S984P	probably damaging	Het
Vangl1	T	C	3: 102,070,667 (GRCm39)	E423G	possibly damaging	Het

Other mutations in Tex264

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01308:Tex264	APN	9	106,539,607 (GRCm39)	missense	possibly damaging	0.95
R0712:Tex264	UTSW	9	106,536,431 (GRCm39)	missense	possibly damaging	0.88
R0737:Tex264	UTSW	9	106,536,498 (GRCm39)	missense	probably benign	0.42
R1579:Tex264	UTSW	9	106,559,116 (GRCm39)	missense	possibly damaging	0.95
R2983:Tex264	UTSW	9	106,559,296 (GRCm39)	missense	unknown
R4772:Tex264	UTSW	9	106,550,901 (GRCm39)	missense	possibly damaging	0.92
R7553:Tex264	UTSW	9	106,536,335 (GRCm39)	missense	probably damaging	0.99
R9437:Tex264	UTSW	9	106,559,096 (GRCm39)	missense	possibly damaging	0.90

Posted On

2013-12-03