Incidental Mutation 'IGL01535:Olfr167'
ID 89926
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr167
Ensembl Gene ENSMUSG00000045341
Gene Name olfactory receptor 167
Synonyms MOR272-1, GA_x54KRFPKG5P-15963726-15962788
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.335) question?
Stock # IGL01535
Quality Score
Status
Chromosome 16
Chromosomal Location 19509558-19522266 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 19515478 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 53 (H53Y)
Ref Sequence ENSEMBL: ENSMUSP00000150102 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054606] [ENSMUST00000214315]
AlphaFold Q8VGJ5
Predicted Effect probably benign
Transcript: ENSMUST00000054606
AA Change: H53Y

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000055344
Gene: ENSMUSG00000045341
AA Change: H53Y

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 4.8e-46 PFAM
Pfam:7TM_GPCR_Srsx 33 295 1.2e-6 PFAM
Pfam:7tm_1 40 289 1.8e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214315
AA Change: H53Y

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217566
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930021J03Rik T C 19: 29,753,812 H600R possibly damaging Het
Adamts19 T A 18: 58,968,819 S654T probably benign Het
Cacnb3 A T 15: 98,639,588 Q49L probably benign Het
Dapk1 A G 13: 60,731,031 probably benign Het
Dopey2 T A 16: 93,769,958 L1091* probably null Het
Epb42 A G 2: 121,027,688 V263A probably damaging Het
Fig4 T G 10: 41,256,494 S439R probably benign Het
Gatc A T 5: 115,340,989 V54E possibly damaging Het
Hook2 T C 8: 85,002,989 L686P probably benign Het
Med12l A T 3: 59,262,259 T1615S probably damaging Het
Msr1 C T 8: 39,611,673 G320D probably benign Het
Nbeal1 T A 1: 60,217,255 F220I probably damaging Het
Olfr113 T A 17: 37,574,788 I212F possibly damaging Het
Pcdh10 A T 3: 45,379,643 I131F probably damaging Het
Phlpp2 A G 8: 109,934,065 E784G possibly damaging Het
Prr36 A T 8: 4,214,043 probably benign Het
Ptprq G A 10: 107,699,596 S436L probably benign Het
Rock1 T A 18: 10,132,119 probably benign Het
Sash1 T G 10: 8,741,577 T522P probably damaging Het
Serpinb2 T C 1: 107,519,773 probably null Het
Supt16 T C 14: 52,177,190 K422E probably damaging Het
Syt14 T G 1: 192,986,765 D60A probably damaging Het
Tbc1d2b A C 9: 90,215,473 probably benign Het
Thsd7b T C 1: 129,678,217 I565T possibly damaging Het
Ttn A G 2: 76,734,192 Y28534H probably damaging Het
Vmn1r177 T A 7: 23,866,340 H37L probably damaging Het
Vps13b A T 15: 35,454,957 N671Y possibly damaging Het
Other mutations in Olfr167
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02115:Olfr167 APN 16 19515103 missense probably damaging 1.00
IGL02562:Olfr167 APN 16 19514964 missense possibly damaging 0.74
BB008:Olfr167 UTSW 16 19515508 missense possibly damaging 0.94
BB018:Olfr167 UTSW 16 19515508 missense possibly damaging 0.94
R0366:Olfr167 UTSW 16 19514848 missense probably benign 0.13
R0673:Olfr167 UTSW 16 19515396 missense probably damaging 1.00
R1187:Olfr167 UTSW 16 19515046 missense probably benign 0.01
R1237:Olfr167 UTSW 16 19515625 missense probably benign 0.01
R1975:Olfr167 UTSW 16 19514836 missense probably damaging 0.99
R1977:Olfr167 UTSW 16 19514836 missense probably damaging 0.99
R1997:Olfr167 UTSW 16 19515042 missense probably damaging 1.00
R2225:Olfr167 UTSW 16 19515246 missense probably benign 0.05
R2226:Olfr167 UTSW 16 19515246 missense probably benign 0.05
R4078:Olfr167 UTSW 16 19515232 missense possibly damaging 0.76
R5019:Olfr167 UTSW 16 19515535 missense probably damaging 0.99
R5071:Olfr167 UTSW 16 19515027 missense probably benign 0.00
R5278:Olfr167 UTSW 16 19515378 nonsense probably null
R5415:Olfr167 UTSW 16 19515246 missense possibly damaging 0.94
R5744:Olfr167 UTSW 16 19515336 missense probably benign 0.00
R5991:Olfr167 UTSW 16 19514757 missense probably damaging 0.99
R6151:Olfr167 UTSW 16 19515531 missense probably damaging 1.00
R6540:Olfr167 UTSW 16 19514821 missense probably benign
R7014:Olfr167 UTSW 16 19515456 missense probably benign 0.20
R7145:Olfr167 UTSW 16 19514899 missense probably damaging 0.99
R7535:Olfr167 UTSW 16 19514794 missense probably damaging 1.00
R7677:Olfr167 UTSW 16 19514928 missense probably benign 0.42
R7715:Olfr167 UTSW 16 19514730 missense probably benign 0.00
R7931:Olfr167 UTSW 16 19515508 missense possibly damaging 0.94
R8137:Olfr167 UTSW 16 19515096 missense possibly damaging 0.89
R8671:Olfr167 UTSW 16 19515054 missense possibly damaging 0.63
Posted On 2013-12-03