Incidental Mutation 'IGL01535:Prr36'
ID89927
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prr36
Ensembl Gene ENSMUSG00000064125
Gene Nameproline rich 36
SynonymsBC068157
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.141) question?
Stock #IGL01535
Quality Score
Status
Chromosome8
Chromosomal Location4209543-4217459 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) A to T at 4214043 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135130 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168386] [ENSMUST00000175906] [ENSMUST00000176227] [ENSMUST00000177491]
Predicted Effect unknown
Transcript: ENSMUST00000168386
AA Change: L541Q
SMART Domains Protein: ENSMUSP00000133114
Gene: ENSMUSG00000064125
AA Change: L541Q

DomainStartEndE-ValueType
low complexity region 26 38 N/A INTRINSIC
internal_repeat_1 63 82 5.9e-10 PROSPERO
internal_repeat_1 87 106 5.9e-10 PROSPERO
low complexity region 109 123 N/A INTRINSIC
low complexity region 358 388 N/A INTRINSIC
low complexity region 390 425 N/A INTRINSIC
low complexity region 466 497 N/A INTRINSIC
low complexity region 543 567 N/A INTRINSIC
low complexity region 571 612 N/A INTRINSIC
low complexity region 647 726 N/A INTRINSIC
low complexity region 733 751 N/A INTRINSIC
low complexity region 755 780 N/A INTRINSIC
low complexity region 783 867 N/A INTRINSIC
low complexity region 1020 1045 N/A INTRINSIC
Pfam:DUF4596 1053 1098 4.1e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000175906
SMART Domains Protein: ENSMUSP00000135713
Gene: ENSMUSG00000064125

DomainStartEndE-ValueType
low complexity region 26 38 N/A INTRINSIC
internal_repeat_1 63 82 5.38e-8 PROSPERO
internal_repeat_1 87 106 5.38e-8 PROSPERO
low complexity region 109 123 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176227
Predicted Effect probably benign
Transcript: ENSMUST00000176645
Predicted Effect probably benign
Transcript: ENSMUST00000177491
SMART Domains Protein: ENSMUSP00000135130
Gene: ENSMUSG00000064125

DomainStartEndE-ValueType
low complexity region 26 38 N/A INTRINSIC
internal_repeat_1 63 82 1.65e-6 PROSPERO
internal_repeat_1 87 106 1.65e-6 PROSPERO
low complexity region 109 123 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large protein of unknown function that contains internal regions of low complexity sequence. Alternative splicing results in multiple transcript variants. The transcript structure of the protein-coding variant at this locus is conserved between human and mouse. [provided by RefSeq, Oct 2013]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930021J03Rik T C 19: 29,753,812 H600R possibly damaging Het
Adamts19 T A 18: 58,968,819 S654T probably benign Het
Cacnb3 A T 15: 98,639,588 Q49L probably benign Het
Dapk1 A G 13: 60,731,031 probably benign Het
Dopey2 T A 16: 93,769,958 L1091* probably null Het
Epb42 A G 2: 121,027,688 V263A probably damaging Het
Fig4 T G 10: 41,256,494 S439R probably benign Het
Gatc A T 5: 115,340,989 V54E possibly damaging Het
Hook2 T C 8: 85,002,989 L686P probably benign Het
Med12l A T 3: 59,262,259 T1615S probably damaging Het
Msr1 C T 8: 39,611,673 G320D probably benign Het
Nbeal1 T A 1: 60,217,255 F220I probably damaging Het
Olfr113 T A 17: 37,574,788 I212F possibly damaging Het
Olfr167 G A 16: 19,515,478 H53Y probably benign Het
Pcdh10 A T 3: 45,379,643 I131F probably damaging Het
Phlpp2 A G 8: 109,934,065 E784G possibly damaging Het
Ptprq G A 10: 107,699,596 S436L probably benign Het
Rock1 T A 18: 10,132,119 probably benign Het
Sash1 T G 10: 8,741,577 T522P probably damaging Het
Serpinb2 T C 1: 107,519,773 probably null Het
Supt16 T C 14: 52,177,190 K422E probably damaging Het
Syt14 T G 1: 192,986,765 D60A probably damaging Het
Tbc1d2b A C 9: 90,215,473 probably benign Het
Thsd7b T C 1: 129,678,217 I565T possibly damaging Het
Ttn A G 2: 76,734,192 Y28534H probably damaging Het
Vmn1r177 T A 7: 23,866,340 H37L probably damaging Het
Vps13b A T 15: 35,454,957 N671Y possibly damaging Het
Other mutations in Prr36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01410:Prr36 APN 8 4216230 missense probably benign 0.01
IGL01658:Prr36 APN 8 4215243 missense probably damaging 1.00
IGL01710:Prr36 APN 8 4215243 missense probably damaging 1.00
IGL01712:Prr36 APN 8 4215243 missense probably damaging 1.00
IGL01713:Prr36 APN 8 4215243 missense probably damaging 1.00
IGL01892:Prr36 APN 8 4215243 missense probably damaging 1.00
IGL01893:Prr36 APN 8 4215243 missense probably damaging 1.00
IGL02496:Prr36 APN 8 4216407 nonsense probably null
IGL02829:Prr36 APN 8 4215278 missense possibly damaging 0.55
R0479:Prr36 UTSW 8 4213930 nonsense probably null
R0667:Prr36 UTSW 8 4216311 unclassified probably benign
R0784:Prr36 UTSW 8 4213771 unclassified probably benign
R1737:Prr36 UTSW 8 4214370 unclassified probably benign
R2017:Prr36 UTSW 8 4215205 missense probably benign 0.02
R2032:Prr36 UTSW 8 4214304 unclassified probably benign
R2430:Prr36 UTSW 8 4213488 unclassified probably benign
R4160:Prr36 UTSW 8 4212910 missense probably benign 0.10
R4184:Prr36 UTSW 8 4213409 unclassified probably benign
R4393:Prr36 UTSW 8 4214901 unclassified probably benign
R4887:Prr36 UTSW 8 4210881 missense probably benign 0.01
R5508:Prr36 UTSW 8 4216488 missense probably damaging 0.99
R5628:Prr36 UTSW 8 4216273 small deletion probably benign
R6189:Prr36 UTSW 8 4214177 unclassified probably benign
R6277:Prr36 UTSW 8 4214746 unclassified probably benign
R7185:Prr36 UTSW 8 4216458 missense probably damaging 1.00
R7286:Prr36 UTSW 8 4215163 critical splice donor site probably benign
R7338:Prr36 UTSW 8 4216212 missense probably damaging 1.00
R7604:Prr36 UTSW 8 4214836 missense unknown
R7621:Prr36 UTSW 8 4213150 missense unknown
R7703:Prr36 UTSW 8 4212982 missense probably benign 0.03
R7842:Prr36 UTSW 8 4210953 missense probably benign 0.09
R7853:Prr36 UTSW 8 4213905 missense unknown
R7925:Prr36 UTSW 8 4210953 missense probably benign 0.09
R7936:Prr36 UTSW 8 4213905 missense unknown
RF044:Prr36 UTSW 8 4216273 small deletion probably benign
Posted On2013-12-03