Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01536:Vmn2r31'

89940

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r31

Ensembl Gene

ENSMUSG00000096373

Gene Name

vomeronasal 2, receptor 31

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.192) question?

Stock #

IGL01536

Quality Score

Status

Chromosome

Chromosomal Location

7386984-7402626 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 7387847 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamic Acid at position 575 (K575E)

Ref Sequence

ENSEMBL: ENSMUSP00000074613 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075108]

AlphaFold

L7N1Z4

Predicted Effect

probably damaging
Transcript: ENSMUST00000075108
AA Change: K575E

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000074613
Gene: ENSMUSG00000096373
AA Change: K575E

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	1e-33	PFAM
Pfam:NCD3G	512	565	1.4e-20	PFAM
Pfam:7tm_3	598	833	8.1e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp5f1a	T	C	18: 77,868,012 (GRCm39)		probably benign	Het
Ccnc	A	G	4: 21,732,505 (GRCm39)	I81V	probably benign	Het
Cep112	A	G	11: 108,422,237 (GRCm39)	D560G	probably null	Het
Dis3	A	G	14: 99,316,859 (GRCm39)	Y826H	probably damaging	Het
Dtx2	A	G	5: 136,038,940 (GRCm39)		probably benign	Het
Enpp4	T	C	17: 44,410,494 (GRCm39)	K361E	possibly damaging	Het
Erap1	A	T	13: 74,810,542 (GRCm39)	K294*	probably null	Het
Erbb4	T	A	1: 68,329,441 (GRCm39)	Y636F	probably benign	Het
Fads1	C	A	19: 10,171,394 (GRCm39)	Q342K	probably benign	Het
Fntb	A	T	12: 76,966,904 (GRCm39)	T447S	probably benign	Het
Hdac4	A	G	1: 91,857,868 (GRCm39)		probably benign	Het
Kcnh2	A	G	5: 24,531,522 (GRCm39)	I463T	probably damaging	Het
Kif13a	G	T	13: 46,905,765 (GRCm39)	T726K	probably damaging	Het
Lcmt1	T	C	7: 123,021,966 (GRCm39)	S275P	possibly damaging	Het
Lmnb1	T	C	18: 56,873,868 (GRCm39)	S425P	probably benign	Het
Lrp1b	T	C	2: 41,000,895 (GRCm39)	I2224V	probably benign	Het
Lrrc45	A	T	11: 120,606,410 (GRCm39)	T173S	probably benign	Het
Muc4	T	C	16: 32,584,340 (GRCm39)	Y2590H	possibly damaging	Het
Myo18a	C	T	11: 77,711,677 (GRCm39)	P676L	probably damaging	Het
Or5m10	T	C	2: 85,717,944 (GRCm39)	S267P	probably damaging	Het
Pcdhb15	T	C	18: 37,608,046 (GRCm39)	M426T	probably benign	Het
Pik3cd	A	G	4: 149,737,123 (GRCm39)	V891A	probably damaging	Het
Polr1b	A	G	2: 128,967,475 (GRCm39)	N956S	probably benign	Het
Ppil3	T	C	1: 58,483,750 (GRCm39)	M1V	probably null	Het
Rad1	T	A	15: 10,493,286 (GRCm39)	S238T	possibly damaging	Het
Shc3	A	C	13: 51,670,595 (GRCm39)	S51A	probably damaging	Het
Slc9c1	T	C	16: 45,409,992 (GRCm39)		probably null	Het
Smg5	A	G	3: 88,256,552 (GRCm39)	K273E	possibly damaging	Het
Sntg1	C	T	1: 8,653,424 (GRCm39)		probably null	Het
Sstr4	T	C	2: 148,237,800 (GRCm39)	L137P	probably damaging	Het
Taar8b	C	T	10: 23,967,493 (GRCm39)	V234I	probably benign	Het
Tbc1d9	A	G	8: 83,987,621 (GRCm39)	Y860C	probably damaging	Het
Tll1	A	T	8: 64,527,323 (GRCm39)	S399R	probably damaging	Het
Tns1	T	C	1: 73,958,807 (GRCm39)		probably benign	Het
Trim10	T	A	17: 37,188,180 (GRCm39)		probably null	Het
Ttn	C	T	2: 76,562,695 (GRCm39)		probably null	Het
Usp43	T	C	11: 67,746,764 (GRCm39)	D981G	probably benign	Het
Vmn2r108	A	T	17: 20,683,543 (GRCm39)	C554S	probably damaging	Het
Vmn2r112	T	A	17: 22,824,136 (GRCm39)	Y464N	probably damaging	Het
Vmn2r50	C	T	7: 9,771,610 (GRCm39)	C697Y	probably damaging	Het
Zcchc8	A	C	5: 123,858,782 (GRCm39)		probably null	Het

Other mutations in Vmn2r31

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01104:Vmn2r31	APN	7	7,399,565 (GRCm39)	missense	probably damaging	0.98
IGL01985:Vmn2r31	APN	7	7,397,510 (GRCm39)	missense	probably benign
IGL02116:Vmn2r31	APN	7	7,397,548 (GRCm39)	missense	probably damaging	0.97
FR4304:Vmn2r31	UTSW	7	7,387,607 (GRCm39)	missense	probably damaging	1.00
R1609:Vmn2r31	UTSW	7	7,387,888 (GRCm39)	missense	probably damaging	1.00
R4647:Vmn2r31	UTSW	7	7,387,367 (GRCm39)	missense	probably damaging	1.00
R4724:Vmn2r31	UTSW	7	7,387,757 (GRCm39)	missense	possibly damaging	0.63
R4824:Vmn2r31	UTSW	7	7,390,062 (GRCm39)	critical splice donor site	probably null
R5619:Vmn2r31	UTSW	7	7,387,529 (GRCm39)	nonsense	probably null
R6225:Vmn2r31	UTSW	7	7,397,638 (GRCm39)	missense	probably benign	0.19
R6610:Vmn2r31	UTSW	7	7,387,588 (GRCm39)	missense	probably damaging	0.97
R6956:Vmn2r31	UTSW	7	7,397,505 (GRCm39)	missense	probably benign
R7111:Vmn2r31	UTSW	7	7,399,480 (GRCm39)	missense	probably damaging	0.99
R7219:Vmn2r31	UTSW	7	7,397,397 (GRCm39)	missense	probably damaging	0.97
R7219:Vmn2r31	UTSW	7	7,390,105 (GRCm39)	missense	probably benign
R7300:Vmn2r31	UTSW	7	7,387,775 (GRCm39)	missense	possibly damaging	0.61
R7395:Vmn2r31	UTSW	7	7,387,744 (GRCm39)	missense	probably damaging	1.00
R7481:Vmn2r31	UTSW	7	7,387,579 (GRCm39)	missense	possibly damaging	0.94
R8015:Vmn2r31	UTSW	7	7,387,199 (GRCm39)	missense	probably damaging	1.00
R8434:Vmn2r31	UTSW	7	7,387,699 (GRCm39)	missense	probably damaging	1.00
R8781:Vmn2r31	UTSW	7	7,387,400 (GRCm39)	missense	possibly damaging	0.65
R8972:Vmn2r31	UTSW	7	7,399,654 (GRCm39)	missense	probably benign	0.00
R9034:Vmn2r31	UTSW	7	7,397,680 (GRCm39)	missense	probably benign	0.08
R9596:Vmn2r31	UTSW	7	7,397,292 (GRCm39)	missense	probably benign	0.01
R9711:Vmn2r31	UTSW	7	7,387,085 (GRCm39)	missense	probably damaging	0.99
R9714:Vmn2r31	UTSW	7	7,387,367 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-03