Incidental Mutation 'IGL01536:Taar8b'
ID89946
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Taar8b
Ensembl Gene ENSMUSG00000100186
Gene Nametrace amine-associated receptor 8B
SynonymsLOC382348
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.095) question?
Stock #IGL01536
Quality Score
Status
Chromosome10
Chromosomal Location24091260-24092294 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 24091595 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 234 (V234I)
Ref Sequence ENSEMBL: ENSMUSP00000090324 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092654]
Predicted Effect probably benign
Transcript: ENSMUST00000092654
AA Change: V234I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000090324
Gene: ENSMUSG00000100186
AA Change: V234I

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 39 244 1.4e-8 PFAM
Pfam:7TM_GPCR_Srsx 42 327 1.1e-14 PFAM
Pfam:7tm_1 48 312 6.4e-57 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp5a1 T C 18: 77,780,312 probably benign Het
Ccnc A G 4: 21,732,505 I81V probably benign Het
Cep112 A G 11: 108,531,411 D560G probably null Het
Dis3 A G 14: 99,079,423 Y826H probably damaging Het
Dtx2 A G 5: 136,010,086 probably benign Het
Enpp4 T C 17: 44,099,603 K361E possibly damaging Het
Erap1 A T 13: 74,662,423 K294* probably null Het
Erbb4 T A 1: 68,290,282 Y636F probably benign Het
Fads1 C A 19: 10,194,030 Q342K probably benign Het
Fntb A T 12: 76,920,130 T447S probably benign Het
Hdac4 A G 1: 91,930,146 probably benign Het
Kcnh2 A G 5: 24,326,524 I463T probably damaging Het
Kif13a G T 13: 46,752,289 T726K probably damaging Het
Lcmt1 T C 7: 123,422,743 S275P possibly damaging Het
Lmnb1 T C 18: 56,740,796 S425P probably benign Het
Lrp1b T C 2: 41,110,883 I2224V probably benign Het
Lrrc45 A T 11: 120,715,584 T173S probably benign Het
Muc4 T C 16: 32,763,966 Y2590H possibly damaging Het
Myo18a C T 11: 77,820,851 P676L probably damaging Het
Olfr1023 T C 2: 85,887,600 S267P probably damaging Het
Pcdhb15 T C 18: 37,474,993 M426T probably benign Het
Pik3cd A G 4: 149,652,666 V891A probably damaging Het
Polr1b A G 2: 129,125,555 N956S probably benign Het
Ppil3 T C 1: 58,444,591 M1V probably null Het
Rad1 T A 15: 10,493,200 S238T possibly damaging Het
Shc3 A C 13: 51,516,559 S51A probably damaging Het
Slc9c1 T C 16: 45,589,629 probably null Het
Smg5 A G 3: 88,349,245 K273E possibly damaging Het
Sntg1 C T 1: 8,583,200 probably null Het
Sstr4 T C 2: 148,395,880 L137P probably damaging Het
Tbc1d9 A G 8: 83,260,992 Y860C probably damaging Het
Tll1 A T 8: 64,074,289 S399R probably damaging Het
Tns1 T C 1: 73,919,648 probably benign Het
Trim10 T A 17: 36,877,288 probably null Het
Ttn C T 2: 76,732,351 probably null Het
Usp43 T C 11: 67,855,938 D981G probably benign Het
Vmn2r108 A T 17: 20,463,281 C554S probably damaging Het
Vmn2r112 T A 17: 22,605,155 Y464N probably damaging Het
Vmn2r31 T C 7: 7,384,848 K575E probably damaging Het
Vmn2r50 C T 7: 10,037,683 C697Y probably damaging Het
Zcchc8 A C 5: 123,720,719 probably null Het
Other mutations in Taar8b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00333:Taar8b APN 10 24091756 missense possibly damaging 0.69
IGL01380:Taar8b APN 10 24092107 missense probably damaging 1.00
IGL02192:Taar8b APN 10 24091364 missense probably damaging 1.00
IGL02282:Taar8b APN 10 24091555 missense possibly damaging 0.83
R0730:Taar8b UTSW 10 24092026 missense probably damaging 1.00
R1871:Taar8b UTSW 10 24092002 missense probably damaging 1.00
R2051:Taar8b UTSW 10 24091314 missense probably benign 0.38
R2265:Taar8b UTSW 10 24091372 missense probably damaging 0.99
R2267:Taar8b UTSW 10 24091372 missense probably damaging 0.99
R2268:Taar8b UTSW 10 24091372 missense probably damaging 0.99
R2269:Taar8b UTSW 10 24091372 missense probably damaging 0.99
R4598:Taar8b UTSW 10 24091838 missense probably benign
R4633:Taar8b UTSW 10 24092252 nonsense probably null
R4833:Taar8b UTSW 10 24092132 missense possibly damaging 0.77
R4949:Taar8b UTSW 10 24091927 missense probably damaging 1.00
R6104:Taar8b UTSW 10 24092237 missense probably damaging 1.00
R6178:Taar8b UTSW 10 24091813 missense probably benign 0.01
R6495:Taar8b UTSW 10 24091262 makesense probably null
R6816:Taar8b UTSW 10 24092181 missense probably benign 0.00
R6913:Taar8b UTSW 10 24092065 missense possibly damaging 0.95
R7072:Taar8b UTSW 10 24091978 missense possibly damaging 0.95
R7691:Taar8b UTSW 10 24091538 nonsense probably null
Posted On2013-12-03