Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01536:Vmn2r112'

89947

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r112

Ensembl Gene

ENSMUSG00000094921

Gene Name

vomeronasal 2, receptor 112

Synonyms

EG628185

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.157) question?

Stock #

IGL01536

Quality Score

Status

Chromosome

Chromosomal Location

22601148-22619133 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 22605155 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 464 (Y464N)

Ref Sequence

ENSEMBL: ENSMUSP00000094994 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097381]

Predicted Effect

probably damaging
Transcript: ENSMUST00000097381
AA Change: Y464N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: Y464N

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.8e-32	PFAM
Pfam:NCD3G	512	565	5.8e-21	PFAM
Pfam:7tm_3	598	833	6.5e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp5a1	T	C	18: 77,780,312		probably benign	Het
Ccnc	A	G	4: 21,732,505	I81V	probably benign	Het
Cep112	A	G	11: 108,531,411	D560G	probably null	Het
Dis3	A	G	14: 99,079,423	Y826H	probably damaging	Het
Dtx2	A	G	5: 136,010,086		probably benign	Het
Enpp4	T	C	17: 44,099,603	K361E	possibly damaging	Het
Erap1	A	T	13: 74,662,423	K294*	probably null	Het
Erbb4	T	A	1: 68,290,282	Y636F	probably benign	Het
Fads1	C	A	19: 10,194,030	Q342K	probably benign	Het
Fntb	A	T	12: 76,920,130	T447S	probably benign	Het
Hdac4	A	G	1: 91,930,146		probably benign	Het
Kcnh2	A	G	5: 24,326,524	I463T	probably damaging	Het
Kif13a	G	T	13: 46,752,289	T726K	probably damaging	Het
Lcmt1	T	C	7: 123,422,743	S275P	possibly damaging	Het
Lmnb1	T	C	18: 56,740,796	S425P	probably benign	Het
Lrp1b	T	C	2: 41,110,883	I2224V	probably benign	Het
Lrrc45	A	T	11: 120,715,584	T173S	probably benign	Het
Muc4	T	C	16: 32,763,966	Y2590H	possibly damaging	Het
Myo18a	C	T	11: 77,820,851	P676L	probably damaging	Het
Olfr1023	T	C	2: 85,887,600	S267P	probably damaging	Het
Pcdhb15	T	C	18: 37,474,993	M426T	probably benign	Het
Pik3cd	A	G	4: 149,652,666	V891A	probably damaging	Het
Polr1b	A	G	2: 129,125,555	N956S	probably benign	Het
Ppil3	T	C	1: 58,444,591	M1V	probably null	Het
Rad1	T	A	15: 10,493,200	S238T	possibly damaging	Het
Shc3	A	C	13: 51,516,559	S51A	probably damaging	Het
Slc9c1	T	C	16: 45,589,629		probably null	Het
Smg5	A	G	3: 88,349,245	K273E	possibly damaging	Het
Sntg1	C	T	1: 8,583,200		probably null	Het
Sstr4	T	C	2: 148,395,880	L137P	probably damaging	Het
Taar8b	C	T	10: 24,091,595	V234I	probably benign	Het
Tbc1d9	A	G	8: 83,260,992	Y860C	probably damaging	Het
Tll1	A	T	8: 64,074,289	S399R	probably damaging	Het
Tns1	T	C	1: 73,919,648		probably benign	Het
Trim10	T	A	17: 36,877,288		probably null	Het
Ttn	C	T	2: 76,732,351		probably null	Het
Usp43	T	C	11: 67,855,938	D981G	probably benign	Het
Vmn2r108	A	T	17: 20,463,281	C554S	probably damaging	Het
Vmn2r31	T	C	7: 7,384,848	K575E	probably damaging	Het
Vmn2r50	C	T	7: 10,037,683	C697Y	probably damaging	Het
Zcchc8	A	C	5: 123,720,719		probably null	Het

Other mutations in Vmn2r112

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Vmn2r112	APN	17	22618936	missense	probably benign	0.13
IGL01021:Vmn2r112	APN	17	22618904	missense	probably damaging	1.00
IGL01122:Vmn2r112	APN	17	22603007	missense	probably benign	0.00
IGL01360:Vmn2r112	APN	17	22618622	missense	probably benign	0.03
IGL02148:Vmn2r112	APN	17	22619032	missense	probably damaging	1.00
IGL02465:Vmn2r112	APN	17	22614994	missense	probably damaging	1.00
PIT4576001:Vmn2r112	UTSW	17	22614931	missense	probably benign	0.00
R0278:Vmn2r112	UTSW	17	22603006	missense	probably benign	0.44
R0328:Vmn2r112	UTSW	17	22605270	missense	probably benign	0.01
R0583:Vmn2r112	UTSW	17	22618949	missense	probably damaging	1.00
R0831:Vmn2r112	UTSW	17	22614999	missense	probably damaging	0.99
R1080:Vmn2r112	UTSW	17	22618999	missense	probably damaging	1.00
R1245:Vmn2r112	UTSW	17	22603247	missense	probably benign	0.03
R1321:Vmn2r112	UTSW	17	22618519	nonsense	probably null
R1381:Vmn2r112	UTSW	17	22618486	missense	probably damaging	1.00
R1514:Vmn2r112	UTSW	17	22602844	missense	probably benign	0.40
R1519:Vmn2r112	UTSW	17	22618903	missense	possibly damaging	0.83
R1572:Vmn2r112	UTSW	17	22603144	missense	possibly damaging	0.61
R1590:Vmn2r112	UTSW	17	22615008	critical splice donor site	probably null
R1640:Vmn2r112	UTSW	17	22605116	missense	probably benign	0.01
R2221:Vmn2r112	UTSW	17	22601233	missense	possibly damaging	0.86
R2223:Vmn2r112	UTSW	17	22601233	missense	possibly damaging	0.86
R2310:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2312:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2337:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2339:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2340:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2341:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2342:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2401:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2860:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2861:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2926:Vmn2r112	UTSW	17	22615003	missense	possibly damaging	0.90
R3236:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R3237:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R3977:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R3979:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R4168:Vmn2r112	UTSW	17	22603088	missense	probably benign	0.01
R4256:Vmn2r112	UTSW	17	22618412	missense	probably damaging	1.00
R4386:Vmn2r112	UTSW	17	22601322	missense	probably benign	0.36
R4912:Vmn2r112	UTSW	17	22603382	missense	probably damaging	0.99
R4947:Vmn2r112	UTSW	17	22602879	missense	probably benign	0.02
R5446:Vmn2r112	UTSW	17	22618250	missense	probably damaging	1.00
R5870:Vmn2r112	UTSW	17	22619023	missense	probably benign	0.00
R6351:Vmn2r112	UTSW	17	22601278	missense	probably benign
R6384:Vmn2r112	UTSW	17	22605155	missense	probably damaging	1.00
R6390:Vmn2r112	UTSW	17	22605249	missense	probably benign	0.01
R6401:Vmn2r112	UTSW	17	22603551	nonsense	probably null
R6405:Vmn2r112	UTSW	17	22618235	missense	probably damaging	1.00
R6620:Vmn2r112	UTSW	17	22603101	missense	probably benign	0.00
R6648:Vmn2r112	UTSW	17	22618486	missense	probably damaging	1.00
R6649:Vmn2r112	UTSW	17	22601179	missense	probably null	1.00
R6653:Vmn2r112	UTSW	17	22601179	missense	probably null	1.00
R6654:Vmn2r112	UTSW	17	22603469	missense	possibly damaging	0.89
R6700:Vmn2r112	UTSW	17	22603481	missense	possibly damaging	0.53
R6993:Vmn2r112	UTSW	17	22603214	missense	probably benign	0.01
R7052:Vmn2r112	UTSW	17	22602526	missense	probably benign
R7454:Vmn2r112	UTSW	17	22603307	missense	probably benign	0.00
R7763:Vmn2r112	UTSW	17	22603118	missense	probably damaging	1.00
Z1088:Vmn2r112	UTSW	17	22605078	missense	possibly damaging	0.89

Posted On

2013-12-03