Incidental Mutation 'IGL01537:Zgpat'
ID90021
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zgpat
Ensembl Gene ENSMUSG00000027582
Gene Namezinc finger, CCCH-type with G patch domain
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01537
Quality Score
Status
Chromosome2
Chromosomal Location181364928-181383628 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 181378889 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 285 (D285G)
Ref Sequence ENSEMBL: ENSMUSP00000112067 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029105] [ENSMUST00000048077] [ENSMUST00000108804] [ENSMUST00000108807] [ENSMUST00000116366]
Predicted Effect probably benign
Transcript: ENSMUST00000029105
AA Change: D285G

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000029105
Gene: ENSMUSG00000027582
AA Change: D285G

DomainStartEndE-ValueType
low complexity region 53 64 N/A INTRINSIC
low complexity region 116 128 N/A INTRINSIC
ZnF_C3H1 174 199 5.99e-4 SMART
SCOP:d1g5va_ 218 268 2e-3 SMART
low complexity region 270 287 N/A INTRINSIC
G_patch 311 357 1.34e-9 SMART
low complexity region 379 392 N/A INTRINSIC
coiled coil region 431 505 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000048077
SMART Domains Protein: ENSMUSP00000045010
Gene: ENSMUSG00000090077

DomainStartEndE-ValueType
Pfam:LIME1 27 266 5.6e-113 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108804
SMART Domains Protein: ENSMUSP00000104432
Gene: ENSMUSG00000090077

DomainStartEndE-ValueType
Pfam:LIME1 27 87 9e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108807
AA Change: D285G

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000104435
Gene: ENSMUSG00000027582
AA Change: D285G

DomainStartEndE-ValueType
low complexity region 53 64 N/A INTRINSIC
low complexity region 116 128 N/A INTRINSIC
ZnF_C3H1 174 199 5.99e-4 SMART
SCOP:d1g5va_ 218 268 2e-3 SMART
low complexity region 270 287 N/A INTRINSIC
G_patch 311 357 1.34e-9 SMART
low complexity region 379 392 N/A INTRINSIC
coiled coil region 431 505 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116366
AA Change: D285G

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000112067
Gene: ENSMUSG00000027582
AA Change: D285G

DomainStartEndE-ValueType
low complexity region 53 64 N/A INTRINSIC
low complexity region 116 128 N/A INTRINSIC
ZnF_C3H1 174 199 5.99e-4 SMART
SCOP:d1g5va_ 218 268 2e-3 SMART
low complexity region 270 287 N/A INTRINSIC
G_patch 311 357 1.34e-9 SMART
low complexity region 379 392 N/A INTRINSIC
coiled coil region 431 505 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000126611
SMART Domains Protein: ENSMUSP00000119181
Gene: ENSMUSG00000090077

DomainStartEndE-ValueType
Pfam:LIME1 4 246 9.6e-111 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126733
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126862
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131284
Predicted Effect probably benign
Transcript: ENSMUST00000140943
SMART Domains Protein: ENSMUSP00000117558
Gene: ENSMUSG00000090077

DomainStartEndE-ValueType
Pfam:LIME1 24 189 5.4e-74 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151457
Predicted Effect probably benign
Transcript: ENSMUST00000156258
SMART Domains Protein: ENSMUSP00000122714
Gene: ENSMUSG00000027582

DomainStartEndE-ValueType
G_patch 1 44 1.18e-5 SMART
low complexity region 66 79 N/A INTRINSIC
coiled coil region 117 148 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184328
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atxn1l T C 8: 109,732,680 R317G probably benign Het
B130006D01Rik T A 11: 95,726,166 probably benign Het
Brinp2 T C 1: 158,246,809 T581A probably damaging Het
Cacna1b A T 2: 24,658,528 I1179N probably damaging Het
Cacnb3 A G 15: 98,643,420 D434G probably damaging Het
Cdh19 T C 1: 110,919,611 T423A possibly damaging Het
Chkb C T 15: 89,427,783 probably benign Het
Cit T C 5: 115,933,854 Y623H probably benign Het
Clstn3 G A 6: 124,431,600 R918C possibly damaging Het
Dnah2 T A 11: 69,516,080 M200L probably benign Het
Dnah9 T A 11: 65,947,680 H3097L probably benign Het
Dst T A 1: 34,275,320 L4217H probably damaging Het
Fam107b T A 2: 3,778,528 L80Q probably damaging Het
Fgfr1 T A 8: 25,555,579 C55S probably damaging Het
Igkv4-71 C A 6: 69,243,280 G78* probably null Het
Igsf10 A G 3: 59,330,031 S910P probably benign Het
Ikzf3 T C 11: 98,516,892 D41G probably damaging Het
Larp1 T A 11: 58,042,822 I358N possibly damaging Het
March5 C T 19: 37,210,668 probably benign Het
Mpdz T C 4: 81,369,658 T455A probably damaging Het
Myo1b A G 1: 51,776,351 V612A possibly damaging Het
Nipbl T C 15: 8,350,539 D923G probably benign Het
Nlrp4b T C 7: 10,714,991 F7L probably damaging Het
Npas4 T C 19: 4,987,327 N313S possibly damaging Het
Nynrin T A 14: 55,872,045 N1536K possibly damaging Het
Olfr1212 T C 2: 88,958,541 V25A probably benign Het
Olfr535 A G 7: 140,492,838 N67D probably damaging Het
Olfr975 T A 9: 39,950,625 T49S probably benign Het
Papd7 A T 13: 69,500,559 S693T probably benign Het
Pclo T C 5: 14,539,633 V649A unknown Het
Pom121 A G 5: 135,392,535 probably benign Het
Ptcd2 A T 13: 99,330,013 I224N possibly damaging Het
Rsrp1 C T 4: 134,923,979 P18L unknown Het
Sash1 A T 10: 8,729,658 N989K probably damaging Het
Scn2a T A 2: 65,715,875 H927Q probably benign Het
Selenoi G T 5: 30,256,224 V128F probably damaging Het
Slc25a42 T C 8: 70,189,442 I117V probably benign Het
Spata1 A G 3: 146,489,803 probably benign Het
Sptlc3 A T 2: 139,589,695 Y379F possibly damaging Het
Tinag C T 9: 77,045,603 R33K probably benign Het
Trappc8 T C 18: 20,835,004 D1092G probably benign Het
Xntrpc A G 7: 102,073,194 E22G probably damaging Het
Zbtb7b A G 3: 89,379,971 M397T possibly damaging Het
Other mutations in Zgpat
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02221:Zgpat APN 2 181378858 missense probably benign 0.41
IGL02507:Zgpat APN 2 181366236 missense probably damaging 1.00
IGL03124:Zgpat APN 2 181366180 missense probably benign 0.05
R0559:Zgpat UTSW 2 181380192 splice site probably benign
R1451:Zgpat UTSW 2 181380191 splice site probably benign
R1541:Zgpat UTSW 2 181378865 missense probably benign 0.01
R1758:Zgpat UTSW 2 181378840 missense probably damaging 1.00
R2445:Zgpat UTSW 2 181366160 nonsense probably null
R3038:Zgpat UTSW 2 181366018 unclassified probably benign
R3700:Zgpat UTSW 2 181365646 unclassified probably benign
R4888:Zgpat UTSW 2 181378858 missense probably benign 0.41
R5594:Zgpat UTSW 2 181365627 unclassified probably benign
R6890:Zgpat UTSW 2 181378511 missense probably damaging 0.98
R7023:Zgpat UTSW 2 181366018 unclassified probably benign
R7350:Zgpat UTSW 2 181380435 missense
R7396:Zgpat UTSW 2 181366089 missense probably benign 0.00
Posted On2013-12-03