Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01537:Zgpat'

90021

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zgpat

Ensembl Gene

ENSMUSG00000027582

Gene Name

zinc finger, CCCH-type with G patch domain

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01537

Quality Score

Status

Chromosome

Chromosomal Location

181364928-181383628 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 181378889 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 285 (D285G)

Ref Sequence

ENSEMBL: ENSMUSP00000112067 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029105] [ENSMUST00000048077] [ENSMUST00000108804] [ENSMUST00000108807] [ENSMUST00000116366]

Predicted Effect

probably benign
Transcript: ENSMUST00000029105
AA Change: D285G

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000029105
Gene: ENSMUSG00000027582
AA Change: D285G

Domain	Start	End	E-Value	Type
low complexity region	53	64	N/A	INTRINSIC
low complexity region	116	128	N/A	INTRINSIC
ZnF_C3H1	174	199	5.99e-4	SMART
SCOP:d1g5va_	218	268	2e-3	SMART
low complexity region	270	287	N/A	INTRINSIC
G_patch	311	357	1.34e-9	SMART
low complexity region	379	392	N/A	INTRINSIC
coiled coil region	431	505	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000048077

SMART Domains

Protein: ENSMUSP00000045010
Gene: ENSMUSG00000090077

Domain	Start	End	E-Value	Type
Pfam:LIME1	27	266	5.6e-113	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108804

SMART Domains

Protein: ENSMUSP00000104432
Gene: ENSMUSG00000090077

Domain	Start	End	E-Value	Type
Pfam:LIME1	27	87	9e-29	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108807
AA Change: D285G

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000104435
Gene: ENSMUSG00000027582
AA Change: D285G

Domain	Start	End	E-Value	Type
low complexity region	53	64	N/A	INTRINSIC
low complexity region	116	128	N/A	INTRINSIC
ZnF_C3H1	174	199	5.99e-4	SMART
SCOP:d1g5va_	218	268	2e-3	SMART
low complexity region	270	287	N/A	INTRINSIC
G_patch	311	357	1.34e-9	SMART
low complexity region	379	392	N/A	INTRINSIC
coiled coil region	431	505	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000116366
AA Change: D285G

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000112067
Gene: ENSMUSG00000027582
AA Change: D285G

Domain	Start	End	E-Value	Type
low complexity region	53	64	N/A	INTRINSIC
low complexity region	116	128	N/A	INTRINSIC
ZnF_C3H1	174	199	5.99e-4	SMART
SCOP:d1g5va_	218	268	2e-3	SMART
low complexity region	270	287	N/A	INTRINSIC
G_patch	311	357	1.34e-9	SMART
low complexity region	379	392	N/A	INTRINSIC
coiled coil region	431	505	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000126611

SMART Domains

Protein: ENSMUSP00000119181
Gene: ENSMUSG00000090077

Domain	Start	End	E-Value	Type
Pfam:LIME1	4	246	9.6e-111	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126733

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126862

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131284

Predicted Effect

probably benign
Transcript: ENSMUST00000140943

SMART Domains

Protein: ENSMUSP00000117558
Gene: ENSMUSG00000090077

Domain	Start	End	E-Value	Type
Pfam:LIME1	24	189	5.4e-74	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151457

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184328

Predicted Effect

probably benign
Transcript: ENSMUST00000156258

SMART Domains

Protein: ENSMUSP00000122714
Gene: ENSMUSG00000027582

Domain	Start	End	E-Value	Type
G_patch	1	44	1.18e-5	SMART
low complexity region	66	79	N/A	INTRINSIC
coiled coil region	117	148	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atxn1l	T	C	8: 109,732,680	R317G	probably benign	Het
B130006D01Rik	T	A	11: 95,726,166		probably benign	Het
Brinp2	T	C	1: 158,246,809	T581A	probably damaging	Het
Cacna1b	A	T	2: 24,658,528	I1179N	probably damaging	Het
Cacnb3	A	G	15: 98,643,420	D434G	probably damaging	Het
Cdh19	T	C	1: 110,919,611	T423A	possibly damaging	Het
Chkb	C	T	15: 89,427,783		probably benign	Het
Cit	T	C	5: 115,933,854	Y623H	probably benign	Het
Clstn3	G	A	6: 124,431,600	R918C	possibly damaging	Het
Dnah2	T	A	11: 69,516,080	M200L	probably benign	Het
Dnah9	T	A	11: 65,947,680	H3097L	probably benign	Het
Dst	T	A	1: 34,275,320	L4217H	probably damaging	Het
Fam107b	T	A	2: 3,778,528	L80Q	probably damaging	Het
Fgfr1	T	A	8: 25,555,579	C55S	probably damaging	Het
Igkv4-71	C	A	6: 69,243,280	G78*	probably null	Het
Igsf10	A	G	3: 59,330,031	S910P	probably benign	Het
Ikzf3	T	C	11: 98,516,892	D41G	probably damaging	Het
Larp1	T	A	11: 58,042,822	I358N	possibly damaging	Het
March5	C	T	19: 37,210,668		probably benign	Het
Mpdz	T	C	4: 81,369,658	T455A	probably damaging	Het
Myo1b	A	G	1: 51,776,351	V612A	possibly damaging	Het
Nipbl	T	C	15: 8,350,539	D923G	probably benign	Het
Nlrp4b	T	C	7: 10,714,991	F7L	probably damaging	Het
Npas4	T	C	19: 4,987,327	N313S	possibly damaging	Het
Nynrin	T	A	14: 55,872,045	N1536K	possibly damaging	Het
Olfr1212	T	C	2: 88,958,541	V25A	probably benign	Het
Olfr535	A	G	7: 140,492,838	N67D	probably damaging	Het
Olfr975	T	A	9: 39,950,625	T49S	probably benign	Het
Papd7	A	T	13: 69,500,559	S693T	probably benign	Het
Pclo	T	C	5: 14,539,633	V649A	unknown	Het
Pom121	A	G	5: 135,392,535		probably benign	Het
Ptcd2	A	T	13: 99,330,013	I224N	possibly damaging	Het
Rsrp1	C	T	4: 134,923,979	P18L	unknown	Het
Sash1	A	T	10: 8,729,658	N989K	probably damaging	Het
Scn2a	T	A	2: 65,715,875	H927Q	probably benign	Het
Selenoi	G	T	5: 30,256,224	V128F	probably damaging	Het
Slc25a42	T	C	8: 70,189,442	I117V	probably benign	Het
Spata1	A	G	3: 146,489,803		probably benign	Het
Sptlc3	A	T	2: 139,589,695	Y379F	possibly damaging	Het
Tinag	C	T	9: 77,045,603	R33K	probably benign	Het
Trappc8	T	C	18: 20,835,004	D1092G	probably benign	Het
Xntrpc	A	G	7: 102,073,194	E22G	probably damaging	Het
Zbtb7b	A	G	3: 89,379,971	M397T	possibly damaging	Het

Other mutations in Zgpat

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02221:Zgpat	APN	2	181378858	missense	probably benign	0.41
IGL02507:Zgpat	APN	2	181366236	missense	probably damaging	1.00
IGL03124:Zgpat	APN	2	181366180	missense	probably benign	0.05
R0559:Zgpat	UTSW	2	181380192	splice site	probably benign
R1451:Zgpat	UTSW	2	181380191	splice site	probably benign
R1541:Zgpat	UTSW	2	181378865	missense	probably benign	0.01
R1758:Zgpat	UTSW	2	181378840	missense	probably damaging	1.00
R2445:Zgpat	UTSW	2	181366160	nonsense	probably null
R3038:Zgpat	UTSW	2	181366018	unclassified	probably benign
R3700:Zgpat	UTSW	2	181365646	unclassified	probably benign
R4888:Zgpat	UTSW	2	181378858	missense	probably benign	0.41
R5594:Zgpat	UTSW	2	181365627	unclassified	probably benign
R6890:Zgpat	UTSW	2	181378511	missense	probably damaging	0.98
R7023:Zgpat	UTSW	2	181366018	unclassified	probably benign
R7350:Zgpat	UTSW	2	181380435	missense
R7396:Zgpat	UTSW	2	181366089	missense	probably benign	0.00
R7964:Zgpat	UTSW	2	181378481	missense	probably benign	0.03
Z1176:Zgpat	UTSW	2	181365729	missense	probably damaging	1.00

Posted On

2013-12-03