Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01542:Tdrd9'

90178

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tdrd9

Ensembl Gene

ENSMUSG00000054003

Gene Name

tudor domain containing 9

Synonyms

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.309) question?

Stock #

IGL01542

Quality Score

Status

Chromosome

Chromosomal Location

111971559-112068854 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 112046989 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 1219 (M1219T)

Ref Sequence

ENSEMBL: ENSMUSP00000078022 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079009]

AlphaFold

Q14BI7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000079009
AA Change: M1219T

PolyPhen 2 Score 0.940 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000078022
Gene: ENSMUSG00000054003
AA Change: M1219T

Domain	Start	End	E-Value	Type
low complexity region	29	40	N/A	INTRINSIC
low complexity region	70	81	N/A	INTRINSIC
DEXDc	132	327	5.64e-21	SMART
HELICc	404	502	3.22e-16	SMART
low complexity region	547	561	N/A	INTRINSIC
HA2	565	666	1.9e-20	SMART
TUDOR	944	1003	1.52e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000191808

Predicted Effect

probably benign
Transcript: ENSMUST00000192125

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Male homozygous mice are sterile, displaying small testis, arrest of male meiosis and abnormal spermatocyte morphology. Females are fertile. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700016C15Rik	A	G	1: 177,743,384	T95A	possibly damaging	Het
Arap3	G	A	18: 37,990,836	R377C	probably damaging	Het
Arhgap20	A	G	9: 51,838,887	M316V	probably benign	Het
Chd7	T	G	4: 8,859,285	N2458K	possibly damaging	Het
Clock	T	C	5: 76,231,475	E538G	possibly damaging	Het
Clpb	G	A	7: 101,787,505	V596I	probably damaging	Het
Col9a3	T	C	2: 180,609,316		probably benign	Het
D130043K22Rik	G	A	13: 24,876,037		probably null	Het
Drd4	T	C	7: 141,293,831		probably benign	Het
Fam228b	A	T	12: 4,763,055	I105N	probably damaging	Het
Gm20939	A	T	17: 94,874,293		probably benign	Het
Gm4952	A	G	19: 12,618,407	T54A	possibly damaging	Het
Hbs1l	T	C	10: 21,307,756	V132A	probably benign	Het
Kpna2	T	A	11: 106,991,201	E266D	probably benign	Het
Lars	T	C	18: 42,214,827	E977G	probably benign	Het
Lrrn4	T	C	2: 132,879,472	T142A	probably benign	Het
Myo19	T	C	11: 84,909,546	L919P	probably damaging	Het
Nhlrc1	A	T	13: 47,014,131	F217I	probably damaging	Het
Olfr1495	T	C	19: 13,768,537	F65S	probably damaging	Het
Plch1	T	C	3: 63,731,649	I468V	probably damaging	Het
Rergl	T	A	6: 139,493,498		probably null	Het
Sctr	A	G	1: 120,044,769		probably benign	Het
Sdhb	T	C	4: 140,972,967	V126A	probably benign	Het
Smad3	C	T	9: 63,655,586	R214Q	probably damaging	Het
Tmem167b	A	T	3: 108,558,906	N75K	possibly damaging	Het
Vmn2r83	T	C	10: 79,479,012	S365P	probably benign	Het
Vps16	T	C	2: 130,438,394	F153L	probably damaging	Het

Other mutations in Tdrd9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01339:Tdrd9	APN	12	112040434	missense	probably damaging	1.00
IGL01373:Tdrd9	APN	12	112040434	missense	probably damaging	1.00
IGL02967:Tdrd9	APN	12	111992488	missense	possibly damaging	0.50
IGL03063:Tdrd9	APN	12	112044299	missense	probably benign	0.00
IGL03107:Tdrd9	APN	12	112042840	missense	probably damaging	0.98
R0433:Tdrd9	UTSW	12	112025581	nonsense	probably null
R0453:Tdrd9	UTSW	12	112068239	missense	probably benign
R0655:Tdrd9	UTSW	12	112040465	missense	probably damaging	1.00
R0666:Tdrd9	UTSW	12	112007580	intron	probably benign
R1073:Tdrd9	UTSW	12	112023259	missense	probably damaging	1.00
R1280:Tdrd9	UTSW	12	112039408	missense	probably damaging	1.00
R1386:Tdrd9	UTSW	12	112044804	missense	probably benign	0.21
R1521:Tdrd9	UTSW	12	112036410	missense	probably damaging	1.00
R1601:Tdrd9	UTSW	12	112023253	nonsense	probably null
R1651:Tdrd9	UTSW	12	112024706	missense	probably damaging	0.97
R1715:Tdrd9	UTSW	12	112036439	missense	possibly damaging	0.62
R1854:Tdrd9	UTSW	12	112044812	missense	probably damaging	1.00
R1905:Tdrd9	UTSW	12	112063627	splice site	probably benign
R2386:Tdrd9	UTSW	12	112015900	missense	probably damaging	1.00
R2863:Tdrd9	UTSW	12	112031261	missense	probably benign
R2915:Tdrd9	UTSW	12	112040461	missense	probably damaging	1.00
R2958:Tdrd9	UTSW	12	112041672	missense	probably damaging	0.97
R4033:Tdrd9	UTSW	12	111992539	missense	possibly damaging	0.58
R4087:Tdrd9	UTSW	12	112013486	nonsense	probably null
R4237:Tdrd9	UTSW	12	112067625	nonsense	probably null
R4482:Tdrd9	UTSW	12	112014501	critical splice donor site	probably null
R4501:Tdrd9	UTSW	12	112042809	missense	probably benign	0.00
R4502:Tdrd9	UTSW	12	111993825	missense	probably damaging	1.00
R4715:Tdrd9	UTSW	12	112041689	missense	probably benign	0.00
R4803:Tdrd9	UTSW	12	111996835	nonsense	probably null
R5218:Tdrd9	UTSW	12	112063475	intron	probably benign
R5275:Tdrd9	UTSW	12	112051912	nonsense	probably null
R5295:Tdrd9	UTSW	12	112051912	nonsense	probably null
R5301:Tdrd9	UTSW	12	112036529	critical splice donor site	probably null
R5339:Tdrd9	UTSW	12	112027122	missense	probably damaging	1.00
R5500:Tdrd9	UTSW	12	112023268	missense	probably benign	0.02
R5573:Tdrd9	UTSW	12	111997902	splice site	probably null
R5590:Tdrd9	UTSW	12	112051980	missense	probably benign	0.01
R5891:Tdrd9	UTSW	12	112042719	missense	probably damaging	1.00
R6056:Tdrd9	UTSW	12	111985041	missense	probably damaging	1.00
R6057:Tdrd9	UTSW	12	112013286	missense	possibly damaging	0.85
R6125:Tdrd9	UTSW	12	112068198	missense	possibly damaging	0.89
R6254:Tdrd9	UTSW	12	112025900	splice site	probably null
R6335:Tdrd9	UTSW	12	112041752	critical splice donor site	probably null
R6345:Tdrd9	UTSW	12	112034608	missense	probably damaging	0.99
R6792:Tdrd9	UTSW	12	112027113	missense	probably benign	0.01
R6956:Tdrd9	UTSW	12	112036354	splice site	probably benign
R6987:Tdrd9	UTSW	12	112025593	missense	possibly damaging	0.82
R7090:Tdrd9	UTSW	12	111992470	missense	probably benign
R7158:Tdrd9	UTSW	12	112036366	missense	probably benign	0.08
R7220:Tdrd9	UTSW	12	112014454	missense	probably damaging	1.00
R7478:Tdrd9	UTSW	12	111985042	missense	probably damaging	1.00
R7489:Tdrd9	UTSW	12	112067637	missense	probably benign	0.00
R7751:Tdrd9	UTSW	12	111992548	missense	probably benign	0.09
R7809:Tdrd9	UTSW	12	112032721	missense	probably damaging	0.99
R7844:Tdrd9	UTSW	12	111997952	missense	possibly damaging	0.63
R7854:Tdrd9	UTSW	12	112046961	missense	probably benign	0.00
R7903:Tdrd9	UTSW	12	112051976	missense	possibly damaging	0.95
R7938:Tdrd9	UTSW	12	112031215	missense	possibly damaging	0.86
R8018:Tdrd9	UTSW	12	112032746	missense	probably benign	0.12
R8018:Tdrd9	UTSW	12	112044388	missense	probably damaging	0.99
R8090:Tdrd9	UTSW	12	112015935	missense	probably damaging	1.00
R8157:Tdrd9	UTSW	12	111985066	missense	probably benign	0.44
R8198:Tdrd9	UTSW	12	112040429	missense	probably damaging	1.00
R8203:Tdrd9	UTSW	12	112025630	missense	probably damaging	1.00
R8512:Tdrd9	UTSW	12	112046193	missense	probably benign
R8721:Tdrd9	UTSW	12	112036455	missense	probably damaging	1.00
R8889:Tdrd9	UTSW	12	112013284	missense	probably benign	0.07
R8892:Tdrd9	UTSW	12	112013284	missense	probably benign	0.07
R9276:Tdrd9	UTSW	12	112014501	critical splice donor site	probably null
R9459:Tdrd9	UTSW	12	112025573	missense	probably damaging	1.00
R9484:Tdrd9	UTSW	12	112046250	missense	probably damaging	0.97
X0018:Tdrd9	UTSW	12	112039329	missense	probably benign	0.24
Z1177:Tdrd9	UTSW	12	111971654	missense	probably benign	0.08
Z1177:Tdrd9	UTSW	12	111993891	missense	probably damaging	0.96
Z1177:Tdrd9	UTSW	12	112015921	missense	probably damaging	1.00

Posted On

2013-12-03