Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01542:Vmn2r83'

90192

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r83

Ensembl Gene

ENSMUSG00000091381

Gene Name

vomeronasal 2, receptor 83

Synonyms

EG625029

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

IGL01542

Quality Score

Status

Chromosome

Chromosomal Location

79304792-79327988 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 79314846 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 365 (S365P)

Ref Sequence

ENSEMBL: ENSMUSP00000131426 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167976]

AlphaFold

E9Q0G7

Predicted Effect

probably benign
Transcript: ENSMUST00000167976
AA Change: S365P

PolyPhen 2 Score 0.301 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000131426
Gene: ENSMUSG00000091381
AA Change: S365P

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	79	473	1.5e-33	PFAM
Pfam:NCD3G	516	569	6.2e-22	PFAM
Pfam:7tm_3	602	837	8.1e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arap3	G	A	18: 38,123,889 (GRCm39)	R377C	probably damaging	Het
Arhgap20	A	G	9: 51,750,187 (GRCm39)	M316V	probably benign	Het
Chd7	T	G	4: 8,859,285 (GRCm39)	N2458K	possibly damaging	Het
Clock	T	C	5: 76,379,322 (GRCm39)	E538G	possibly damaging	Het
Clpb	G	A	7: 101,436,712 (GRCm39)	V596I	probably damaging	Het
Col9a3	T	C	2: 180,251,109 (GRCm39)		probably benign	Het
D130043K22Rik	G	A	13: 25,060,020 (GRCm39)		probably null	Het
Drd4	T	C	7: 140,873,744 (GRCm39)		probably benign	Het
Fam228b	A	T	12: 4,813,055 (GRCm39)	I105N	probably damaging	Het
Gm20939	A	T	17: 95,181,721 (GRCm39)		probably benign	Het
Gm4952	A	G	19: 12,595,771 (GRCm39)	T54A	possibly damaging	Het
Hbs1l	T	C	10: 21,183,655 (GRCm39)	V132A	probably benign	Het
Kpna2	T	A	11: 106,882,027 (GRCm39)	E266D	probably benign	Het
Lars1	T	C	18: 42,347,892 (GRCm39)	E977G	probably benign	Het
Lrrn4	T	C	2: 132,721,392 (GRCm39)	T142A	probably benign	Het
Myo19	T	C	11: 84,800,372 (GRCm39)	L919P	probably damaging	Het
Nhlrc1	A	T	13: 47,167,607 (GRCm39)	F217I	probably damaging	Het
Or10q12	T	C	19: 13,745,901 (GRCm39)	F65S	probably damaging	Het
Plch1	T	C	3: 63,639,070 (GRCm39)	I468V	probably damaging	Het
Rergl	T	A	6: 139,470,496 (GRCm39)		probably null	Het
Sctr	A	G	1: 119,972,499 (GRCm39)		probably benign	Het
Sdhb	T	C	4: 140,700,278 (GRCm39)	V126A	probably benign	Het
Smad3	C	T	9: 63,562,868 (GRCm39)	R214Q	probably damaging	Het
Spmip3	A	G	1: 177,570,950 (GRCm39)	T95A	possibly damaging	Het
Tdrd9	T	C	12: 112,013,423 (GRCm39)	M1219T	possibly damaging	Het
Tmem167b	A	T	3: 108,466,222 (GRCm39)	N75K	possibly damaging	Het
Vps16	T	C	2: 130,280,314 (GRCm39)	F153L	probably damaging	Het

Other mutations in Vmn2r83

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Vmn2r83	APN	10	79,314,805 (GRCm39)	missense	probably damaging	1.00
IGL01096:Vmn2r83	APN	10	79,313,662 (GRCm39)	missense	probably damaging	1.00
IGL01803:Vmn2r83	APN	10	79,304,894 (GRCm39)	missense	probably benign	0.01
IGL02110:Vmn2r83	APN	10	79,327,534 (GRCm39)	missense	possibly damaging	0.82
IGL02347:Vmn2r83	APN	10	79,316,067 (GRCm39)	missense	possibly damaging	0.75
IGL02417:Vmn2r83	APN	10	79,314,881 (GRCm39)	missense	probably benign	0.00
IGL02544:Vmn2r83	APN	10	79,317,293 (GRCm39)	splice site	probably benign
IGL02683:Vmn2r83	APN	10	79,327,115 (GRCm39)	missense	probably benign
IGL02976:Vmn2r83	APN	10	79,304,832 (GRCm39)	missense	probably benign	0.00
PIT4378001:Vmn2r83	UTSW	10	79,304,849 (GRCm39)	missense	probably benign	0.00
PIT4468001:Vmn2r83	UTSW	10	79,313,884 (GRCm39)	missense	probably damaging	1.00
R0092:Vmn2r83	UTSW	10	79,327,798 (GRCm39)	missense	probably damaging	1.00
R1391:Vmn2r83	UTSW	10	79,314,931 (GRCm39)	missense	probably damaging	0.96
R1539:Vmn2r83	UTSW	10	79,327,759 (GRCm39)	missense	probably damaging	1.00
R1575:Vmn2r83	UTSW	10	79,314,956 (GRCm39)	missense	probably damaging	0.98
R2033:Vmn2r83	UTSW	10	79,327,653 (GRCm39)	missense	probably benign	0.03
R3916:Vmn2r83	UTSW	10	79,314,744 (GRCm39)	missense	probably benign	0.01
R3967:Vmn2r83	UTSW	10	79,327,154 (GRCm39)	missense	probably benign	0.00
R4840:Vmn2r83	UTSW	10	79,313,682 (GRCm39)	missense	possibly damaging	0.73
R5063:Vmn2r83	UTSW	10	79,314,921 (GRCm39)	missense	probably benign	0.04
R5630:Vmn2r83	UTSW	10	79,327,785 (GRCm39)	missense	possibly damaging	0.94
R5707:Vmn2r83	UTSW	10	79,327,183 (GRCm39)	missense	possibly damaging	0.53
R5980:Vmn2r83	UTSW	10	79,314,626 (GRCm39)	missense	probably benign	0.04
R6294:Vmn2r83	UTSW	10	79,313,688 (GRCm39)	missense	probably damaging	0.99
R6302:Vmn2r83	UTSW	10	79,304,837 (GRCm39)	missense	possibly damaging	0.95
R6769:Vmn2r83	UTSW	10	79,313,856 (GRCm39)	missense	probably damaging	1.00
R6986:Vmn2r83	UTSW	10	79,316,093 (GRCm39)	missense	probably benign
R7221:Vmn2r83	UTSW	10	79,316,001 (GRCm39)	missense	probably benign	0.02
R7376:Vmn2r83	UTSW	10	79,314,790 (GRCm39)	missense	probably benign	0.00
R7431:Vmn2r83	UTSW	10	79,327,306 (GRCm39)	missense	probably damaging	0.99
R7501:Vmn2r83	UTSW	10	79,327,771 (GRCm39)	missense	probably damaging	0.98
R7526:Vmn2r83	UTSW	10	79,327,392 (GRCm39)	missense	probably damaging	1.00
R7663:Vmn2r83	UTSW	10	79,314,956 (GRCm39)	missense	probably damaging	0.98
R7881:Vmn2r83	UTSW	10	79,314,261 (GRCm39)	missense	probably benign	0.01
R7939:Vmn2r83	UTSW	10	79,314,651 (GRCm39)	missense	probably damaging	1.00
R8314:Vmn2r83	UTSW	10	79,317,313 (GRCm39)	missense	possibly damaging	0.76
R8364:Vmn2r83	UTSW	10	79,316,037 (GRCm39)	missense	probably benign	0.12
R8802:Vmn2r83	UTSW	10	79,314,261 (GRCm39)	missense	probably benign	0.01
R8947:Vmn2r83	UTSW	10	79,304,873 (GRCm39)	missense	probably benign	0.00
R8969:Vmn2r83	UTSW	10	79,313,853 (GRCm39)	missense	probably benign	0.15
R8983:Vmn2r83	UTSW	10	79,327,360 (GRCm39)	missense	probably damaging	1.00
R9018:Vmn2r83	UTSW	10	79,316,020 (GRCm39)	missense	probably damaging	1.00
R9082:Vmn2r83	UTSW	10	79,304,894 (GRCm39)	missense	probably benign	0.00
R9390:Vmn2r83	UTSW	10	79,317,322 (GRCm39)	nonsense	probably null
X0026:Vmn2r83	UTSW	10	79,314,486 (GRCm39)	missense	probably benign
X0026:Vmn2r83	UTSW	10	79,304,849 (GRCm39)	missense	probably benign	0.00
Z1176:Vmn2r83	UTSW	10	79,314,756 (GRCm39)	missense	possibly damaging	0.74

Posted On

2013-12-03