Incidental Mutation 'IGL01542:Tmem167b'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem167b
Ensembl Gene ENSMUSG00000068732
Gene Nametransmembrane protein 167B
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.214) question?
Stock #IGL01542
Quality Score
Chromosomal Location108556425-108562466 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 108558906 bp
Amino Acid Change Asparagine to Lysine at position 75 (N75K)
Ref Sequence ENSEMBL: ENSMUSP00000102233 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090546] [ENSMUST00000106622]
Predicted Effect possibly damaging
Transcript: ENSMUST00000090546
AA Change: M66K

PolyPhen 2 Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000088035
Gene: ENSMUSG00000068732
AA Change: M66K

Pfam:DUF1242 10 46 7.6e-14 PFAM
transmembrane domain 50 72 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000106622
AA Change: N75K

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000102233
Gene: ENSMUSG00000068732
AA Change: N75K

signal peptide 1 39 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157560
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199996
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016C15Rik A G 1: 177,743,384 T95A possibly damaging Het
Arap3 G A 18: 37,990,836 R377C probably damaging Het
Arhgap20 A G 9: 51,838,887 M316V probably benign Het
Chd7 T G 4: 8,859,285 N2458K possibly damaging Het
Clock T C 5: 76,231,475 E538G possibly damaging Het
Clpb G A 7: 101,787,505 V596I probably damaging Het
Col9a3 T C 2: 180,609,316 probably benign Het
D130043K22Rik G A 13: 24,876,037 probably null Het
Drd4 T C 7: 141,293,831 probably benign Het
Fam228b A T 12: 4,763,055 I105N probably damaging Het
Gm20939 A T 17: 94,874,293 probably benign Het
Gm4952 A G 19: 12,618,407 T54A possibly damaging Het
Hbs1l T C 10: 21,307,756 V132A probably benign Het
Kpna2 T A 11: 106,991,201 E266D probably benign Het
Lars T C 18: 42,214,827 E977G probably benign Het
Lrrn4 T C 2: 132,879,472 T142A probably benign Het
Myo19 T C 11: 84,909,546 L919P probably damaging Het
Nhlrc1 A T 13: 47,014,131 F217I probably damaging Het
Olfr1495 T C 19: 13,768,537 F65S probably damaging Het
Plch1 T C 3: 63,731,649 I468V probably damaging Het
Rergl T A 6: 139,493,498 probably null Het
Sctr A G 1: 120,044,769 probably benign Het
Sdhb T C 4: 140,972,967 V126A probably benign Het
Smad3 C T 9: 63,655,586 R214Q probably damaging Het
Tdrd9 T C 12: 112,046,989 M1219T possibly damaging Het
Vmn2r83 T C 10: 79,479,012 S365P probably benign Het
Vps16 T C 2: 130,438,394 F153L probably damaging Het
Other mutations in Tmem167b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0847:Tmem167b UTSW 3 108560221 missense probably benign
R5310:Tmem167b UTSW 3 108562099 intron probably benign
R5524:Tmem167b UTSW 3 108560253 missense possibly damaging 0.84
R5808:Tmem167b UTSW 3 108560243 missense probably benign 0.27
R6093:Tmem167b UTSW 3 108562123 start codon destroyed probably null
R6358:Tmem167b UTSW 3 108558895 missense possibly damaging 0.94
R7716:Tmem167b UTSW 3 108558897 missense probably damaging 1.00
Posted On2013-12-03