Incidental Mutation 'IGL01542:Lrrn4'
ID90198
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrn4
Ensembl Gene ENSMUSG00000043110
Gene Nameleucine rich repeat neuronal 4
SynonymsB430119L13Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.089) question?
Stock #IGL01542
Quality Score
Status
Chromosome2
Chromosomal Location132868305-132880891 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 132879472 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 142 (T142A)
Ref Sequence ENSEMBL: ENSMUSP00000057005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049787]
Predicted Effect probably benign
Transcript: ENSMUST00000049787
AA Change: T142A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000057005
Gene: ENSMUSG00000043110
AA Change: T142A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
LRR 105 126 7.36e0 SMART
LRR_TYP 128 151 3.44e-4 SMART
LRR 153 175 1.19e1 SMART
LRR 176 199 1.53e1 SMART
LRR 205 228 2.03e1 SMART
LRR 229 253 3.36e2 SMART
LRRCT 311 363 6.92e-2 SMART
low complexity region 520 530 N/A INTRINSIC
FN3 577 656 3.73e-10 SMART
transmembrane domain 679 701 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mutant mice exhibit impaired memory retention in hippocampus- dependent learning tasks such as contextual conditioning and spatial learning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016C15Rik A G 1: 177,743,384 T95A possibly damaging Het
Arap3 G A 18: 37,990,836 R377C probably damaging Het
Arhgap20 A G 9: 51,838,887 M316V probably benign Het
Chd7 T G 4: 8,859,285 N2458K possibly damaging Het
Clock T C 5: 76,231,475 E538G possibly damaging Het
Clpb G A 7: 101,787,505 V596I probably damaging Het
Col9a3 T C 2: 180,609,316 probably benign Het
D130043K22Rik G A 13: 24,876,037 probably null Het
Drd4 T C 7: 141,293,831 probably benign Het
Fam228b A T 12: 4,763,055 I105N probably damaging Het
Gm20939 A T 17: 94,874,293 probably benign Het
Gm4952 A G 19: 12,618,407 T54A possibly damaging Het
Hbs1l T C 10: 21,307,756 V132A probably benign Het
Kpna2 T A 11: 106,991,201 E266D probably benign Het
Lars T C 18: 42,214,827 E977G probably benign Het
Myo19 T C 11: 84,909,546 L919P probably damaging Het
Nhlrc1 A T 13: 47,014,131 F217I probably damaging Het
Olfr1495 T C 19: 13,768,537 F65S probably damaging Het
Plch1 T C 3: 63,731,649 I468V probably damaging Het
Rergl T A 6: 139,493,498 probably null Het
Sctr A G 1: 120,044,769 probably benign Het
Sdhb T C 4: 140,972,967 V126A probably benign Het
Smad3 C T 9: 63,655,586 R214Q probably damaging Het
Tdrd9 T C 12: 112,046,989 M1219T possibly damaging Het
Tmem167b A T 3: 108,558,906 N75K possibly damaging Het
Vmn2r83 T C 10: 79,479,012 S365P probably benign Het
Vps16 T C 2: 130,438,394 F153L probably damaging Het
Other mutations in Lrrn4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00333:Lrrn4 APN 2 132870817 missense probably damaging 1.00
IGL00661:Lrrn4 APN 2 132870668 missense probably benign 0.08
IGL01584:Lrrn4 APN 2 132878076 missense probably damaging 1.00
IGL01723:Lrrn4 APN 2 132870061 missense possibly damaging 0.79
R0270:Lrrn4 UTSW 2 132870719 missense probably benign 0.01
R0348:Lrrn4 UTSW 2 132870443 missense probably benign 0.02
R0400:Lrrn4 UTSW 2 132878020 missense probably benign 0.12
R0701:Lrrn4 UTSW 2 132870160 missense probably benign 0.02
R1465:Lrrn4 UTSW 2 132872075 missense probably damaging 1.00
R1465:Lrrn4 UTSW 2 132872075 missense probably damaging 1.00
R1664:Lrrn4 UTSW 2 132869966 missense probably damaging 1.00
R1987:Lrrn4 UTSW 2 132870443 missense probably benign 0.02
R3409:Lrrn4 UTSW 2 132879861 missense unknown
R3743:Lrrn4 UTSW 2 132869866 splice site probably null
R4678:Lrrn4 UTSW 2 132879568 missense probably benign 0.16
R5770:Lrrn4 UTSW 2 132872156 missense probably damaging 1.00
R6438:Lrrn4 UTSW 2 132870142 missense probably damaging 1.00
R6511:Lrrn4 UTSW 2 132870326 missense probably benign 0.06
R6880:Lrrn4 UTSW 2 132872112 missense probably damaging 0.96
R7132:Lrrn4 UTSW 2 132879693 nonsense probably null
R7273:Lrrn4 UTSW 2 132879829 missense unknown
R7424:Lrrn4 UTSW 2 132869743 missense possibly damaging 0.90
R7710:Lrrn4 UTSW 2 132879531 missense probably benign 0.00
R7980:Lrrn4 UTSW 2 132878176 missense probably damaging 1.00
R8133:Lrrn4 UTSW 2 132878014 missense probably damaging 1.00
R8229:Lrrn4 UTSW 2 132869887 missense probably damaging 1.00
R8489:Lrrn4 UTSW 2 132879444 missense probably benign 0.20
Posted On2013-12-03