Incidental Mutation 'IGL01546:Or7g27'
| ID |
90340 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or7g27
|
| Ensembl Gene |
ENSMUSG00000061614 |
| Gene Name |
olfactory receptor family 7 subfamily G member 27 |
| Synonyms |
MOR150-1P, GA_x6K02T2PVTD-13076685-13077623, MOR150-2, Olfr1522-ps1, MOR150-1, Olfr845, MOR150-1P |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
IGL01546
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
19249755-19250696 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 19250068 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glycine
at position 104
(V104G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150474
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071259]
[ENSMUST00000213344]
[ENSMUST00000215572]
|
| AlphaFold |
Q7TRG2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000071259
AA Change: V104G
PolyPhen 2
Score 0.562 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000071239
Gene: ENSMUSG00000061614
AA Change: V104G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
307 |
1.1e-56 |
PFAM |
|
Pfam:7tm_1
|
41 |
290 |
2.1e-22 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212246
AA Change: V104G
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000213344
AA Change: V104G
PolyPhen 2
Score 0.562 (Sensitivity: 0.88; Specificity: 0.91)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000215572
AA Change: V104G
PolyPhen 2
Score 0.562 (Sensitivity: 0.88; Specificity: 0.91)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Amdhd2 |
C |
A |
17: 24,382,574 (GRCm39) |
R22L |
probably benign |
Het |
| Arg2 |
T |
C |
12: 79,196,633 (GRCm39) |
|
probably benign |
Het |
| Catip |
T |
C |
1: 74,401,954 (GRCm39) |
L43P |
probably damaging |
Het |
| Ccdc30 |
A |
C |
4: 119,255,385 (GRCm39) |
L123R |
probably damaging |
Het |
| Cep89 |
T |
C |
7: 35,120,325 (GRCm39) |
L369P |
probably damaging |
Het |
| Dolpp1 |
T |
C |
2: 30,287,107 (GRCm39) |
F180L |
probably damaging |
Het |
| Kctd19 |
T |
C |
8: 106,113,594 (GRCm39) |
H670R |
probably benign |
Het |
| Kntc1 |
T |
A |
5: 123,903,068 (GRCm39) |
I315N |
probably benign |
Het |
| Mfsd4b2 |
A |
T |
10: 39,797,471 (GRCm39) |
W295R |
probably damaging |
Het |
| Mgam |
A |
G |
6: 40,631,627 (GRCm39) |
T116A |
probably damaging |
Het |
| Mn1 |
A |
T |
5: 111,569,114 (GRCm39) |
D1028V |
probably damaging |
Het |
| Or1e17 |
G |
A |
11: 73,832,020 (GRCm39) |
G316D |
probably benign |
Het |
| Or2ag1b |
A |
G |
7: 106,288,738 (GRCm39) |
S67P |
probably damaging |
Het |
| Or52b1 |
T |
C |
7: 104,978,899 (GRCm39) |
R167G |
probably damaging |
Het |
| Or52j3 |
A |
T |
7: 102,836,617 (GRCm39) |
I270F |
probably damaging |
Het |
| Or7a40 |
A |
G |
16: 16,491,129 (GRCm39) |
S239P |
probably damaging |
Het |
| Phc3 |
C |
A |
3: 31,015,888 (GRCm39) |
A108S |
probably damaging |
Het |
| Pkhd1l1 |
A |
G |
15: 44,429,712 (GRCm39) |
Y3310C |
probably damaging |
Het |
| Ppp4r3b |
T |
C |
11: 29,159,488 (GRCm39) |
|
probably null |
Het |
| Slx4ip |
A |
G |
2: 136,908,119 (GRCm39) |
T159A |
probably benign |
Het |
| Sos1 |
T |
A |
17: 80,716,040 (GRCm39) |
Y974F |
probably damaging |
Het |
| Spaca7b |
T |
A |
8: 11,706,136 (GRCm39) |
M133L |
probably benign |
Het |
| Taar8a |
A |
T |
10: 23,952,813 (GRCm39) |
Y139F |
possibly damaging |
Het |
| Vcam1 |
A |
G |
3: 115,909,591 (GRCm39) |
C579R |
possibly damaging |
Het |
| Zdhhc17 |
C |
T |
10: 110,782,054 (GRCm39) |
V547M |
probably damaging |
Het |
|
| Other mutations in Or7g27 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01637:Or7g27
|
APN |
9 |
19,250,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01767:Or7g27
|
APN |
9 |
19,250,598 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01945:Or7g27
|
APN |
9 |
19,250,628 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02202:Or7g27
|
APN |
9 |
19,250,545 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02877:Or7g27
|
APN |
9 |
19,250,497 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0466:Or7g27
|
UTSW |
9 |
19,250,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1521:Or7g27
|
UTSW |
9 |
19,249,948 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1650:Or7g27
|
UTSW |
9 |
19,249,943 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1766:Or7g27
|
UTSW |
9 |
19,250,154 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2060:Or7g27
|
UTSW |
9 |
19,250,352 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2082:Or7g27
|
UTSW |
9 |
19,250,574 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2257:Or7g27
|
UTSW |
9 |
19,249,789 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2892:Or7g27
|
UTSW |
9 |
19,250,034 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3156:Or7g27
|
UTSW |
9 |
19,250,720 (GRCm39) |
splice site |
probably null |
|
|
R3943:Or7g27
|
UTSW |
9 |
19,250,371 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4116:Or7g27
|
UTSW |
9 |
19,249,940 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4518:Or7g27
|
UTSW |
9 |
19,250,556 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4814:Or7g27
|
UTSW |
9 |
19,250,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5339:Or7g27
|
UTSW |
9 |
19,250,455 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6647:Or7g27
|
UTSW |
9 |
19,249,925 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7493:Or7g27
|
UTSW |
9 |
19,250,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7522:Or7g27
|
UTSW |
9 |
19,250,294 (GRCm39) |
nonsense |
probably null |
|
|
R7584:Or7g27
|
UTSW |
9 |
19,250,569 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9127:Or7g27
|
UTSW |
9 |
19,250,026 (GRCm39) |
missense |
probably benign |
|
|
R9463:Or7g27
|
UTSW |
9 |
19,250,320 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Posted On |
2013-12-03 |
Incidental Mutation