Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01547:Tas2r123'

90359

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r123

Ensembl Gene

Gene Name

taste receptor, type 2, member 123

Synonyms

mt2r55, Tas2r23, STC 9-2, mGR23, T2R23

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01547

Quality Score

Status

Chromosome

Chromosomal Location

132847142-132848143 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 132847458 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 106 (T106I)

Ref Sequence

ENSEMBL: ENSMUSP00000071615 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071696]

Predicted Effect

probably damaging
Transcript: ENSMUST00000071696
AA Change: T106I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000071615
Gene: ENSMUSG00000057381
AA Change: T106I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	322	4.6e-79	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700013G24Rik	G	A	4: 137,455,262	G243R	possibly damaging	Het
Afg3l1	T	C	8: 123,501,351	V625A	probably benign	Het
Arhgap39	T	C	15: 76,737,815		probably benign	Het
Bag1	A	G	4: 40,936,661	C332R	probably damaging	Het
Bcas2	T	C	3: 103,171,999	Y49H	probably damaging	Het
Cacna1b	C	A	2: 24,632,035		probably benign	Het
Cdyl	A	G	13: 35,790,162	D53G	possibly damaging	Het
Csmd3	T	C	15: 47,883,617	I1322V	probably benign	Het
Evc2	C	A	5: 37,393,087	A815E	probably benign	Het
Gm6309	C	T	5: 146,168,411	D231N	probably benign	Het
Mtfr2	C	T	10: 20,357,599	P305S	probably damaging	Het
Olfr301	A	G	7: 86,412,871	N170D	possibly damaging	Het
Olfr639	A	T	7: 104,012,660	I14N	probably benign	Het
Olfr77	A	T	9: 19,920,901	I231F	probably benign	Het
Pcdhb1	A	G	18: 37,267,342	H782R	probably benign	Het
Polr2a	A	G	11: 69,744,942	S480P	probably damaging	Het
Scaf11	T	C	15: 96,418,429	T1085A	probably benign	Het
Sema6c	C	T	3: 95,172,398	R668C	probably damaging	Het
Tgm5	A	G	2: 121,049,202		probably benign	Het
Vmn2r23	T	A	6: 123,704,424	I97N	possibly damaging	Het
Vmn2r6	T	A	3: 64,538,104	K644N	probably damaging	Het
Zfp608	A	G	18: 54,894,449		probably null	Het

Other mutations in Tas2r123

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01021:Tas2r123	APN	6	132847406	missense	probably benign	0.01
IGL02576:Tas2r123	APN	6	132847740	missense	possibly damaging	0.96
IGL03303:Tas2r123	APN	6	132847438	missense	probably damaging	1.00
R0068:Tas2r123	UTSW	6	132847992	missense	possibly damaging	0.66
R0068:Tas2r123	UTSW	6	132847992	missense	possibly damaging	0.66
R0110:Tas2r123	UTSW	6	132847332	missense	probably benign	0.01
R0364:Tas2r123	UTSW	6	132847681	missense	probably benign
R0415:Tas2r123	UTSW	6	132847838	missense	probably damaging	0.97
R0469:Tas2r123	UTSW	6	132847332	missense	probably benign	0.01
R1791:Tas2r123	UTSW	6	132847565	missense	probably damaging	1.00
R1976:Tas2r123	UTSW	6	132847332	missense	probably damaging	0.96
R2328:Tas2r123	UTSW	6	132847316	missense	probably benign	0.02
R4282:Tas2r123	UTSW	6	132848045	missense	possibly damaging	0.75
R4283:Tas2r123	UTSW	6	132848045	missense	possibly damaging	0.75
R4939:Tas2r123	UTSW	6	132847845	missense	probably benign	0.32
R5079:Tas2r123	UTSW	6	132847718	missense	probably benign	0.01
R5241:Tas2r123	UTSW	6	132847218	missense	probably benign	0.06
R5288:Tas2r123	UTSW	6	132847227	missense	probably benign	0.17
R5851:Tas2r123	UTSW	6	132847308	missense	probably damaging	1.00
R6725:Tas2r123	UTSW	6	132847838	missense	probably damaging	0.97
R6895:Tas2r123	UTSW	6	132847170	missense	probably benign
R7017:Tas2r123	UTSW	6	132847550	missense	probably benign	0.00
R7183:Tas2r123	UTSW	6	132847698	missense	possibly damaging	0.95

Posted On

2013-12-03