Incidental Mutation 'IGL01547:Tas2r123'
ID 90359
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r123
Ensembl Gene ENSMUSG00000057381
Gene Name taste receptor, type 2, member 123
Synonyms mt2r55, Tas2r23, STC 9-2, mGR23, T2R23
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.049) question?
Stock # IGL01547
Quality Score
Status
Chromosome 6
Chromosomal Location 132847142-132848143 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 132847458 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 106 (T106I)
Ref Sequence ENSEMBL: ENSMUSP00000071615 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071696]
AlphaFold P59528
Predicted Effect probably damaging
Transcript: ENSMUST00000071696
AA Change: T106I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071615
Gene: ENSMUSG00000057381
AA Change: T106I

DomainStartEndE-ValueType
Pfam:TAS2R 7 322 4.6e-79 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik G A 4: 137,455,262 G243R possibly damaging Het
Afg3l1 T C 8: 123,501,351 V625A probably benign Het
Arhgap39 T C 15: 76,737,815 probably benign Het
Bag1 A G 4: 40,936,661 C332R probably damaging Het
Bcas2 T C 3: 103,171,999 Y49H probably damaging Het
Cacna1b C A 2: 24,632,035 probably benign Het
Cdyl A G 13: 35,790,162 D53G possibly damaging Het
Csmd3 T C 15: 47,883,617 I1322V probably benign Het
Evc2 C A 5: 37,393,087 A815E probably benign Het
Gm6309 C T 5: 146,168,411 D231N probably benign Het
Mtfr2 C T 10: 20,357,599 P305S probably damaging Het
Olfr301 A G 7: 86,412,871 N170D possibly damaging Het
Olfr639 A T 7: 104,012,660 I14N probably benign Het
Olfr77 A T 9: 19,920,901 I231F probably benign Het
Pcdhb1 A G 18: 37,267,342 H782R probably benign Het
Polr2a A G 11: 69,744,942 S480P probably damaging Het
Scaf11 T C 15: 96,418,429 T1085A probably benign Het
Sema6c C T 3: 95,172,398 R668C probably damaging Het
Tgm5 A G 2: 121,049,202 probably benign Het
Vmn2r23 T A 6: 123,704,424 I97N possibly damaging Het
Vmn2r6 T A 3: 64,538,104 K644N probably damaging Het
Zfp608 A G 18: 54,894,449 probably null Het
Other mutations in Tas2r123
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01021:Tas2r123 APN 6 132847406 missense probably benign 0.01
IGL02576:Tas2r123 APN 6 132847740 missense possibly damaging 0.96
IGL03303:Tas2r123 APN 6 132847438 missense probably damaging 1.00
G1patch:Tas2r123 UTSW 6 132847838 missense probably damaging 0.97
R0068:Tas2r123 UTSW 6 132847992 missense possibly damaging 0.66
R0068:Tas2r123 UTSW 6 132847992 missense possibly damaging 0.66
R0110:Tas2r123 UTSW 6 132847332 missense probably benign 0.01
R0364:Tas2r123 UTSW 6 132847681 missense probably benign
R0415:Tas2r123 UTSW 6 132847838 missense probably damaging 0.97
R0469:Tas2r123 UTSW 6 132847332 missense probably benign 0.01
R1791:Tas2r123 UTSW 6 132847565 missense probably damaging 1.00
R1976:Tas2r123 UTSW 6 132847332 missense probably damaging 0.96
R2328:Tas2r123 UTSW 6 132847316 missense probably benign 0.02
R4282:Tas2r123 UTSW 6 132848045 missense possibly damaging 0.75
R4283:Tas2r123 UTSW 6 132848045 missense possibly damaging 0.75
R4939:Tas2r123 UTSW 6 132847845 missense probably benign 0.32
R5079:Tas2r123 UTSW 6 132847718 missense probably benign 0.01
R5241:Tas2r123 UTSW 6 132847218 missense probably benign 0.06
R5288:Tas2r123 UTSW 6 132847227 missense probably benign 0.17
R5851:Tas2r123 UTSW 6 132847308 missense probably damaging 1.00
R6725:Tas2r123 UTSW 6 132847838 missense probably damaging 0.97
R6895:Tas2r123 UTSW 6 132847170 missense probably benign
R7017:Tas2r123 UTSW 6 132847550 missense probably benign 0.00
R7183:Tas2r123 UTSW 6 132847698 missense possibly damaging 0.95
R8972:Tas2r123 UTSW 6 132847370 missense probably benign 0.30
R9321:Tas2r123 UTSW 6 132848132 missense probably benign
Posted On 2013-12-03