Incidental Mutation 'IGL01547:Olfr77'
ID90362
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr77
Ensembl Gene ENSMUSG00000051118
Gene Nameolfactory receptor 77
SynonymsMOR143-1, 18A, GA_x6K02T2PVTD-13660026-13660964
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.068) question?
Stock #IGL01547
Quality Score
Status
Chromosome9
Chromosomal Location19916865-19929124 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 19920901 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 231 (I231F)
Ref Sequence ENSEMBL: ENSMUSP00000149055 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057596] [ENSMUST00000217347]
Predicted Effect probably benign
Transcript: ENSMUST00000057596
AA Change: I231F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000058810
Gene: ENSMUSG00000051118
AA Change: I231F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3e-53 PFAM
Pfam:7tm_1 41 290 1.2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217347
AA Change: I231F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik G A 4: 137,455,262 G243R possibly damaging Het
Afg3l1 T C 8: 123,501,351 V625A probably benign Het
Arhgap39 T C 15: 76,737,815 probably benign Het
Bag1 A G 4: 40,936,661 C332R probably damaging Het
Bcas2 T C 3: 103,171,999 Y49H probably damaging Het
Cacna1b C A 2: 24,632,035 probably benign Het
Cdyl A G 13: 35,790,162 D53G possibly damaging Het
Csmd3 T C 15: 47,883,617 I1322V probably benign Het
Evc2 C A 5: 37,393,087 A815E probably benign Het
Gm6309 C T 5: 146,168,411 D231N probably benign Het
Mtfr2 C T 10: 20,357,599 P305S probably damaging Het
Olfr301 A G 7: 86,412,871 N170D possibly damaging Het
Olfr639 A T 7: 104,012,660 I14N probably benign Het
Pcdhb1 A G 18: 37,267,342 H782R probably benign Het
Polr2a A G 11: 69,744,942 S480P probably damaging Het
Scaf11 T C 15: 96,418,429 T1085A probably benign Het
Sema6c C T 3: 95,172,398 R668C probably damaging Het
Tas2r123 C T 6: 132,847,458 T106I probably damaging Het
Tgm5 A G 2: 121,049,202 probably benign Het
Vmn2r23 T A 6: 123,704,424 I97N possibly damaging Het
Vmn2r6 T A 3: 64,538,104 K644N probably damaging Het
Zfp608 A G 18: 54,894,449 probably null Het
Other mutations in Olfr77
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Olfr77 APN 9 19920949 missense possibly damaging 0.87
IGL01318:Olfr77 APN 9 19920758 missense probably benign 0.44
IGL01635:Olfr77 APN 9 19920484 missense probably damaging 1.00
IGL02112:Olfr77 APN 9 19920525 missense possibly damaging 0.48
IGL02858:Olfr77 APN 9 19920451 missense probably damaging 0.99
IGL02904:Olfr77 APN 9 19921097 missense probably damaging 1.00
IGL02956:Olfr77 APN 9 19921052 missense possibly damaging 0.87
IGL03066:Olfr77 APN 9 19920371 missense probably benign 0.12
R0662:Olfr77 UTSW 9 19920500 missense probably damaging 1.00
R1222:Olfr77 UTSW 9 19921048 missense possibly damaging 0.87
R1572:Olfr77 UTSW 9 19920912 missense probably benign 0.35
R1761:Olfr77 UTSW 9 19921149 makesense probably null
R2409:Olfr77 UTSW 9 19920776 missense probably benign 0.31
R2409:Olfr77 UTSW 9 19920781 missense probably damaging 1.00
R3621:Olfr77 UTSW 9 19920913 missense probably damaging 0.99
R3849:Olfr77 UTSW 9 19920809 missense probably damaging 1.00
R3850:Olfr77 UTSW 9 19920809 missense probably damaging 1.00
R4277:Olfr77 UTSW 9 19920389 missense possibly damaging 0.91
R4768:Olfr77 UTSW 9 19920545 missense possibly damaging 0.56
R4979:Olfr77 UTSW 9 19920359 missense probably benign 0.03
R5276:Olfr77 UTSW 9 19920621 missense possibly damaging 0.87
R5503:Olfr77 UTSW 9 19920379 missense probably benign 0.36
R5760:Olfr77 UTSW 9 19920754 missense probably benign 0.00
R5778:Olfr77 UTSW 9 19921041 missense probably benign 0.20
R5930:Olfr77 UTSW 9 19920910 missense probably damaging 0.99
R6012:Olfr77 UTSW 9 19920941 missense probably damaging 0.99
R7269:Olfr77 UTSW 9 19920335 missense possibly damaging 0.95
R7977:Olfr77 UTSW 9 19920314 missense possibly damaging 0.48
R7987:Olfr77 UTSW 9 19920314 missense possibly damaging 0.48
R8174:Olfr77 UTSW 9 19920724 missense probably damaging 1.00
Z1088:Olfr77 UTSW 9 19920712 missense probably damaging 1.00
Posted On2013-12-03