Incidental Mutation 'IGL01516:Tmem154'
ID90378
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem154
Ensembl Gene ENSMUSG00000056498
Gene Nametransmembrane protein 154
Synonyms9930117H01Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL01516
Quality Score
Status
Chromosome3
Chromosomal Location84666192-84704575 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 84684590 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Tyrosine at position 120 (H120Y)
Ref Sequence ENSEMBL: ENSMUSP00000103310 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107682] [ENSMUST00000154148]
Predicted Effect probably benign
Transcript: ENSMUST00000107682
AA Change: H120Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000103310
Gene: ENSMUSG00000056498
AA Change: H120Y

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:TMEM154 24 163 6.2e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129417
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134890
Predicted Effect probably benign
Transcript: ENSMUST00000154148
SMART Domains Protein: ENSMUSP00000116393
Gene: ENSMUSG00000102805

DomainStartEndE-ValueType
Arfaptin 1 227 7.15e-121 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921517D22Rik A G 13: 59,690,734 S95P probably benign Het
Abca6 T A 11: 110,218,217 H709L possibly damaging Het
BC051142 A G 17: 34,449,260 D168G possibly damaging Het
Bpifb1 A G 2: 154,218,252 Y455C probably benign Het
Clk1 G A 1: 58,414,404 T341I probably damaging Het
Corin A T 5: 72,454,487 Y77* probably null Het
Cps1 C T 1: 67,230,284 R1481C probably damaging Het
Cspg5 A G 9: 110,246,693 K166E probably benign Het
Dcxr A G 11: 120,725,758 probably null Het
Epha5 C A 5: 84,386,276 L65F probably damaging Het
Erbb4 T A 1: 68,328,245 K438* probably null Het
Gldc A T 19: 30,099,032 C1005S probably damaging Het
Hs3st5 C T 10: 36,833,051 T194I probably damaging Het
Hspa12a T A 19: 58,827,676 D45V probably benign Het
Il1rn C T 2: 24,349,539 T130I probably damaging Het
Klk1b22 G T 7: 44,116,308 C196F probably damaging Het
Lamp1 C T 8: 13,173,863 H332Y probably damaging Het
Limd2 T C 11: 106,159,044 T40A probably benign Het
Lztr1 G A 16: 17,522,391 probably null Het
Mbd4 T C 6: 115,849,530 T167A probably damaging Het
Mitf T A 6: 98,010,390 probably null Het
Mlph A G 1: 90,939,390 D378G probably damaging Het
Mrgprb5 A T 7: 48,168,384 L201Q probably damaging Het
Myo5b A T 18: 74,627,195 I261F probably damaging Het
Olfr1413 A T 1: 92,573,443 I91F probably benign Het
Olfr918 C T 9: 38,672,863 V207I probably benign Het
Paics T A 5: 76,956,731 L68I probably damaging Het
Pramef20 A G 4: 144,377,767 V56A probably damaging Het
Prkca C T 11: 107,961,602 V102M probably null Het
Ptpn21 G A 12: 98,715,189 T62I probably damaging Het
Ptpre A T 7: 135,664,999 E212V probably damaging Het
Rufy2 A C 10: 63,011,433 K539Q possibly damaging Het
Serpinb9d T A 13: 33,202,671 probably null Het
Smarcd1 T C 15: 99,712,213 F442L probably benign Het
Tas2r115 A G 6: 132,737,613 V125A probably damaging Het
Tnrc6b A G 15: 80,902,622 K1321E possibly damaging Het
Trmt13 A G 3: 116,589,810 probably benign Het
Vmn1r19 T C 6: 57,404,872 F137L probably benign Het
Vmn1r202 T A 13: 22,501,462 T262S possibly damaging Het
Vmn2r57 A G 7: 41,399,946 V793A probably damaging Het
Wapl A G 14: 34,692,081 N300S probably damaging Het
Xpot T A 10: 121,590,222 probably null Het
Zfp784 G A 7: 5,036,037 probably benign Het
Zfyve26 G T 12: 79,287,851 P131Q probably benign Het
Other mutations in Tmem154
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Tmem154 APN 3 84684415 missense probably benign 0.05
IGL01670:Tmem154 APN 3 84684230 missense probably damaging 0.98
IGL02955:Tmem154 APN 3 84684201 intron probably benign
IGL03406:Tmem154 APN 3 84684260 missense probably benign 0.00
R6245:Tmem154 UTSW 3 84684296 missense possibly damaging 0.83
R6885:Tmem154 UTSW 3 84692506 missense possibly damaging 0.95
R7287:Tmem154 UTSW 3 84690563 missense possibly damaging 0.95
Posted On2013-12-09