Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01516:Mrgprb5'

90413

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgprb5

Ensembl Gene

ENSMUSG00000070551

Gene Name

MAS-related GPR, member B5

Synonyms

MrgB5

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL01516

Quality Score

Status

Chromosome

Chromosomal Location

47817765-47818733 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 47818132 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 201 (L201Q)

Ref Sequence

ENSEMBL: ENSMUSP00000091953 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094389]

AlphaFold

Q91ZB9

Predicted Effect

probably damaging
Transcript: ENSMUST00000094389
AA Change: L201Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000091953
Gene: ENSMUSG00000070551
AA Change: L201Q

Domain	Start	End	E-Value	Type
low complexity region	9	21	N/A	INTRINSIC
Pfam:7TM_GPCR_Srx	38	217	1.4e-8	PFAM
Pfam:7tm_1	47	210	1.7e-7	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921517D22Rik	A	G	13: 59,838,548 (GRCm39)	S95P	probably benign	Het
Abca6	T	A	11: 110,109,043 (GRCm39)	H709L	possibly damaging	Het
Bpifb1	A	G	2: 154,060,172 (GRCm39)	Y455C	probably benign	Het
Clk1	G	A	1: 58,453,563 (GRCm39)	T341I	probably damaging	Het
Corin	A	T	5: 72,611,830 (GRCm39)	Y77*	probably null	Het
Cps1	C	T	1: 67,269,443 (GRCm39)	R1481C	probably damaging	Het
Cspg5	A	G	9: 110,075,761 (GRCm39)	K166E	probably benign	Het
Dcxr	A	G	11: 120,616,584 (GRCm39)		probably null	Het
Epha5	C	A	5: 84,534,135 (GRCm39)	L65F	probably damaging	Het
Erbb4	T	A	1: 68,367,404 (GRCm39)	K438*	probably null	Het
Gldc	A	T	19: 30,076,432 (GRCm39)	C1005S	probably damaging	Het
Hs3st5	C	T	10: 36,709,047 (GRCm39)	T194I	probably damaging	Het
Hspa12a	T	A	19: 58,816,108 (GRCm39)	D45V	probably benign	Het
Il1rn	C	T	2: 24,239,551 (GRCm39)	T130I	probably damaging	Het
Klk1b22	G	T	7: 43,765,732 (GRCm39)	C196F	probably damaging	Het
Lamp1	C	T	8: 13,223,863 (GRCm39)	H332Y	probably damaging	Het
Limd2	T	C	11: 106,049,870 (GRCm39)	T40A	probably benign	Het
Lztr1	G	A	16: 17,340,255 (GRCm39)		probably null	Het
Mbd4	T	C	6: 115,826,491 (GRCm39)	T167A	probably damaging	Het
Mitf	T	A	6: 97,987,351 (GRCm39)		probably null	Het
Mlph	A	G	1: 90,867,112 (GRCm39)	D378G	probably damaging	Het
Myo5b	A	T	18: 74,760,266 (GRCm39)	I261F	probably damaging	Het
Or8b3b	C	T	9: 38,584,159 (GRCm39)	V207I	probably benign	Het
Or9s23	A	T	1: 92,501,165 (GRCm39)	I91F	probably benign	Het
Paics	T	A	5: 77,104,578 (GRCm39)	L68I	probably damaging	Het
Pramel15	A	G	4: 144,104,337 (GRCm39)	V56A	probably damaging	Het
Prkca	C	T	11: 107,852,428 (GRCm39)	V102M	probably null	Het
Ptpn21	G	A	12: 98,681,448 (GRCm39)	T62I	probably damaging	Het
Ptpre	A	T	7: 135,266,728 (GRCm39)	E212V	probably damaging	Het
Rufy2	A	C	10: 62,847,212 (GRCm39)	K539Q	possibly damaging	Het
Serpinb9d	T	A	13: 33,386,654 (GRCm39)		probably null	Het
Smarcd1	T	C	15: 99,610,094 (GRCm39)	F442L	probably benign	Het
Tas2r115	A	G	6: 132,714,576 (GRCm39)	V125A	probably damaging	Het
Tmem154	C	T	3: 84,591,897 (GRCm39)	H120Y	probably benign	Het
Tnrc6b	A	G	15: 80,786,823 (GRCm39)	K1321E	possibly damaging	Het
Trmt13	A	G	3: 116,383,459 (GRCm39)		probably benign	Het
Tsbp1	A	G	17: 34,668,234 (GRCm39)	D168G	possibly damaging	Het
Vmn1r19	T	C	6: 57,381,857 (GRCm39)	F137L	probably benign	Het
Vmn1r202	T	A	13: 22,685,632 (GRCm39)	T262S	possibly damaging	Het
Vmn2r57	A	G	7: 41,049,370 (GRCm39)	V793A	probably damaging	Het
Wapl	A	G	14: 34,414,038 (GRCm39)	N300S	probably damaging	Het
Xpot	T	A	10: 121,426,127 (GRCm39)		probably null	Het
Zfp784	G	A	7: 5,039,036 (GRCm39)		probably benign	Het
Zfyve26	G	T	12: 79,334,625 (GRCm39)	P131Q	probably benign	Het

Other mutations in Mrgprb5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01662:Mrgprb5	APN	7	47,818,172 (GRCm39)	missense	probably benign	0.02
IGL01752:Mrgprb5	APN	7	47,818,415 (GRCm39)	missense	probably benign	0.22
IGL02117:Mrgprb5	APN	7	47,818,742 (GRCm39)	utr 5 prime	probably benign
IGL02866:Mrgprb5	APN	7	47,817,914 (GRCm39)	missense	probably damaging	0.99
IGL03382:Mrgprb5	APN	7	47,818,442 (GRCm39)	missense	probably benign	0.01
R0545:Mrgprb5	UTSW	7	47,818,633 (GRCm39)	missense	probably benign	0.08
R1389:Mrgprb5	UTSW	7	47,818,078 (GRCm39)	missense	probably damaging	1.00
R1939:Mrgprb5	UTSW	7	47,818,686 (GRCm39)	missense	probably benign	0.00
R2277:Mrgprb5	UTSW	7	47,818,579 (GRCm39)	missense	probably damaging	1.00
R2367:Mrgprb5	UTSW	7	47,818,347 (GRCm39)	nonsense	probably null
R2912:Mrgprb5	UTSW	7	47,817,815 (GRCm39)	missense	probably benign
R2968:Mrgprb5	UTSW	7	47,818,317 (GRCm39)	missense	probably damaging	0.98
R2969:Mrgprb5	UTSW	7	47,818,317 (GRCm39)	missense	probably damaging	0.98
R2970:Mrgprb5	UTSW	7	47,818,317 (GRCm39)	missense	probably damaging	0.98
R3499:Mrgprb5	UTSW	7	47,818,661 (GRCm39)	missense	probably benign	0.04
R3828:Mrgprb5	UTSW	7	47,817,839 (GRCm39)	missense	probably benign	0.01
R4590:Mrgprb5	UTSW	7	47,817,809 (GRCm39)	missense	probably benign	0.16
R4719:Mrgprb5	UTSW	7	47,818,526 (GRCm39)	missense	probably damaging	1.00
R5263:Mrgprb5	UTSW	7	47,817,937 (GRCm39)	missense	probably damaging	0.99
R5264:Mrgprb5	UTSW	7	47,817,796 (GRCm39)	missense	probably benign	0.10
R5644:Mrgprb5	UTSW	7	47,817,955 (GRCm39)	missense	probably benign	0.00
R6485:Mrgprb5	UTSW	7	47,818,525 (GRCm39)	missense	probably damaging	0.99
R6713:Mrgprb5	UTSW	7	47,818,537 (GRCm39)	missense	probably damaging	0.98
R7112:Mrgprb5	UTSW	7	47,818,655 (GRCm39)	missense	probably benign
R7176:Mrgprb5	UTSW	7	47,818,059 (GRCm39)	missense	possibly damaging	0.68
R7446:Mrgprb5	UTSW	7	47,818,252 (GRCm39)	missense	possibly damaging	0.65
R7640:Mrgprb5	UTSW	7	47,818,007 (GRCm39)	missense	probably benign	0.00
R7831:Mrgprb5	UTSW	7	47,817,997 (GRCm39)	missense	probably benign	0.05
R9041:Mrgprb5	UTSW	7	47,818,509 (GRCm39)	missense	probably damaging	1.00
R9314:Mrgprb5	UTSW	7	47,818,174 (GRCm39)	missense	probably benign	0.09

Posted On

2013-12-09