Incidental Mutation 'IGL01516:Xpot'
ID 90418
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Xpot
Ensembl Gene ENSMUSG00000034667
Gene Name exportin, tRNA (nuclear export receptor for tRNAs)
Synonyms EXPORTIN-T, 1110004L07Rik, C79645
Accession Numbers
Essential gene? Probably essential (E-score: 0.949) question?
Stock # IGL01516
Quality Score
Status
Chromosome 10
Chromosomal Location 121423285-121462237 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 121426127 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151935 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020316] [ENSMUST00000039810] [ENSMUST00000218004] [ENSMUST00000219400] [ENSMUST00000219493]
AlphaFold Q9CRT8
Predicted Effect probably null
Transcript: ENSMUST00000020316
SMART Domains Protein: ENSMUSP00000020316
Gene: ENSMUSG00000020115

DomainStartEndE-ValueType
Pfam:Pkinase 9 300 2.6e-46 PFAM
Pfam:Pkinase_Tyr 10 250 1.5e-27 PFAM
low complexity region 355 366 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000039810
SMART Domains Protein: ENSMUSP00000043488
Gene: ENSMUSG00000034667

DomainStartEndE-ValueType
IBN_N 21 89 1.37e-3 SMART
Pfam:Xpo1 98 248 5.1e-42 PFAM
low complexity region 386 399 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000218004
Predicted Effect probably null
Transcript: ENSMUST00000219334
Predicted Effect probably benign
Transcript: ENSMUST00000219400
Predicted Effect probably null
Transcript: ENSMUST00000219493
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(22) : Targeted, other(2) Gene trapped(20)

Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921517D22Rik A G 13: 59,838,548 (GRCm39) S95P probably benign Het
Abca6 T A 11: 110,109,043 (GRCm39) H709L possibly damaging Het
Bpifb1 A G 2: 154,060,172 (GRCm39) Y455C probably benign Het
Clk1 G A 1: 58,453,563 (GRCm39) T341I probably damaging Het
Corin A T 5: 72,611,830 (GRCm39) Y77* probably null Het
Cps1 C T 1: 67,269,443 (GRCm39) R1481C probably damaging Het
Cspg5 A G 9: 110,075,761 (GRCm39) K166E probably benign Het
Dcxr A G 11: 120,616,584 (GRCm39) probably null Het
Epha5 C A 5: 84,534,135 (GRCm39) L65F probably damaging Het
Erbb4 T A 1: 68,367,404 (GRCm39) K438* probably null Het
Gldc A T 19: 30,076,432 (GRCm39) C1005S probably damaging Het
Hs3st5 C T 10: 36,709,047 (GRCm39) T194I probably damaging Het
Hspa12a T A 19: 58,816,108 (GRCm39) D45V probably benign Het
Il1rn C T 2: 24,239,551 (GRCm39) T130I probably damaging Het
Klk1b22 G T 7: 43,765,732 (GRCm39) C196F probably damaging Het
Lamp1 C T 8: 13,223,863 (GRCm39) H332Y probably damaging Het
Limd2 T C 11: 106,049,870 (GRCm39) T40A probably benign Het
Lztr1 G A 16: 17,340,255 (GRCm39) probably null Het
Mbd4 T C 6: 115,826,491 (GRCm39) T167A probably damaging Het
Mitf T A 6: 97,987,351 (GRCm39) probably null Het
Mlph A G 1: 90,867,112 (GRCm39) D378G probably damaging Het
Mrgprb5 A T 7: 47,818,132 (GRCm39) L201Q probably damaging Het
Myo5b A T 18: 74,760,266 (GRCm39) I261F probably damaging Het
Or8b3b C T 9: 38,584,159 (GRCm39) V207I probably benign Het
Or9s23 A T 1: 92,501,165 (GRCm39) I91F probably benign Het
Paics T A 5: 77,104,578 (GRCm39) L68I probably damaging Het
Pramel15 A G 4: 144,104,337 (GRCm39) V56A probably damaging Het
Prkca C T 11: 107,852,428 (GRCm39) V102M probably null Het
Ptpn21 G A 12: 98,681,448 (GRCm39) T62I probably damaging Het
Ptpre A T 7: 135,266,728 (GRCm39) E212V probably damaging Het
Rufy2 A C 10: 62,847,212 (GRCm39) K539Q possibly damaging Het
Serpinb9d T A 13: 33,386,654 (GRCm39) probably null Het
Smarcd1 T C 15: 99,610,094 (GRCm39) F442L probably benign Het
Tas2r115 A G 6: 132,714,576 (GRCm39) V125A probably damaging Het
Tmem154 C T 3: 84,591,897 (GRCm39) H120Y probably benign Het
Tnrc6b A G 15: 80,786,823 (GRCm39) K1321E possibly damaging Het
Trmt13 A G 3: 116,383,459 (GRCm39) probably benign Het
Tsbp1 A G 17: 34,668,234 (GRCm39) D168G possibly damaging Het
Vmn1r19 T C 6: 57,381,857 (GRCm39) F137L probably benign Het
Vmn1r202 T A 13: 22,685,632 (GRCm39) T262S possibly damaging Het
Vmn2r57 A G 7: 41,049,370 (GRCm39) V793A probably damaging Het
Wapl A G 14: 34,414,038 (GRCm39) N300S probably damaging Het
Zfp784 G A 7: 5,039,036 (GRCm39) probably benign Het
Zfyve26 G T 12: 79,334,625 (GRCm39) P131Q probably benign Het
Other mutations in Xpot
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Xpot APN 10 121,441,549 (GRCm39) missense probably benign
IGL01286:Xpot APN 10 121,438,243 (GRCm39) missense probably benign 0.03
IGL01364:Xpot APN 10 121,440,399 (GRCm39) missense probably benign 0.08
IGL01370:Xpot APN 10 121,440,399 (GRCm39) missense probably benign 0.08
IGL01530:Xpot APN 10 121,447,433 (GRCm39) missense probably damaging 0.99
IGL02047:Xpot APN 10 121,437,267 (GRCm39) unclassified probably benign
IGL02207:Xpot APN 10 121,449,485 (GRCm39) missense probably damaging 1.00
IGL02340:Xpot APN 10 121,451,109 (GRCm39) missense probably damaging 1.00
IGL02408:Xpot APN 10 121,439,070 (GRCm39) missense probably damaging 1.00
IGL03150:Xpot APN 10 121,445,091 (GRCm39) missense probably benign 0.00
IGL03210:Xpot APN 10 121,451,132 (GRCm39) splice site probably benign
3-1:Xpot UTSW 10 121,449,264 (GRCm39) missense probably benign 0.00
R0077:Xpot UTSW 10 121,441,544 (GRCm39) missense probably benign 0.09
R1750:Xpot UTSW 10 121,438,932 (GRCm39) critical splice donor site probably null
R1806:Xpot UTSW 10 121,443,543 (GRCm39) splice site probably benign
R1950:Xpot UTSW 10 121,455,053 (GRCm39) missense probably benign
R2227:Xpot UTSW 10 121,458,765 (GRCm39) missense probably damaging 0.98
R2304:Xpot UTSW 10 121,447,488 (GRCm39) missense probably benign 0.02
R3914:Xpot UTSW 10 121,440,443 (GRCm39) missense possibly damaging 0.72
R4784:Xpot UTSW 10 121,450,968 (GRCm39) splice site probably null
R4884:Xpot UTSW 10 121,442,713 (GRCm39) missense probably damaging 1.00
R4904:Xpot UTSW 10 121,453,083 (GRCm39) missense probably benign 0.00
R5218:Xpot UTSW 10 121,455,043 (GRCm39) missense probably damaging 0.99
R5361:Xpot UTSW 10 121,436,765 (GRCm39) missense possibly damaging 0.71
R5651:Xpot UTSW 10 121,440,454 (GRCm39) missense probably damaging 0.99
R5894:Xpot UTSW 10 121,449,551 (GRCm39) missense probably damaging 1.00
R5915:Xpot UTSW 10 121,450,998 (GRCm39) missense probably damaging 0.97
R6139:Xpot UTSW 10 121,447,613 (GRCm39) missense probably benign 0.41
R6182:Xpot UTSW 10 121,442,163 (GRCm39) missense probably damaging 1.00
R6896:Xpot UTSW 10 121,449,390 (GRCm39) critical splice donor site probably null
R7024:Xpot UTSW 10 121,438,304 (GRCm39) missense probably benign 0.35
R7146:Xpot UTSW 10 121,442,678 (GRCm39) missense probably damaging 1.00
R7272:Xpot UTSW 10 121,453,094 (GRCm39) critical splice acceptor site probably null
R7556:Xpot UTSW 10 121,449,411 (GRCm39) missense probably benign 0.01
R7882:Xpot UTSW 10 121,454,996 (GRCm39) critical splice donor site probably null
R7916:Xpot UTSW 10 121,458,848 (GRCm39) start gained probably benign
R8087:Xpot UTSW 10 121,437,232 (GRCm39) missense probably benign
R8224:Xpot UTSW 10 121,443,513 (GRCm39) missense probably damaging 1.00
R8303:Xpot UTSW 10 121,447,405 (GRCm39) nonsense probably null
R9036:Xpot UTSW 10 121,447,580 (GRCm39) missense probably damaging 1.00
R9046:Xpot UTSW 10 121,432,149 (GRCm39) nonsense probably null
R9393:Xpot UTSW 10 121,445,600 (GRCm39) critical splice donor site probably null
R9716:Xpot UTSW 10 121,447,392 (GRCm39) missense probably benign
Z1088:Xpot UTSW 10 121,437,228 (GRCm39) missense probably damaging 0.99
Z1176:Xpot UTSW 10 121,453,079 (GRCm39) missense probably damaging 1.00
Posted On 2013-12-09